Original Article: Phase 1 Study of Anito-cel, a ᴅ-Domain BCMA CAR T Cell for Refractory or Recurrent Myeloma https://t.co/rqr5r9gTcR
Science behind the Study: Anito-cel for Multiple Myeloma https://t.co/oNdvXQB5Ip
#Hematology
A 25-year-old man presented with personality changes,abnormal movements, jaundice and pruritus. MRl showing gaint panda sign
Comment your diagnosis?
A. Wilson's disease
B. Huntington's disease
C. Hemochromatosis
D. Sarcoidosis
🛑Answer is D
📍Furosemide is a loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
⚡MOA :
📍Furosemide exerts direct vasodilatory effects, which results in its therapeutic effectiveness in the treatment of acute pulmonary edema.
📍Vasodilation leads to reduced responsiveness to vasoconstrictors, such as angiotensin II and noradrenaline, and decreased production of endogenous natriuretic hormones with vasoconstricting properties.
📍It also leads to increased production of prostaglandins with vasodilating properties.
📍Furosemide may also open potassium channels in resistance arteries.
📍The main mechanism of action of furosemide is independent of its inhibitory effect on carbonic anhydrase and aldosterone.
ECG Patterns of Occlusion Myocardial Infarction (OMI)
STEMI criteria alone can miss up to a quarter of true acute coronary occlusions. Here’s a complete guide to subtle but high-risk OMI ECG patterns every clinician should master.
A thread 👇 😍