Sigurgeir Olafsson

A research scientist in deCODE genetics, Iceland studying somatic evolution in cancer, normal tissues and complex traits.
Previously at the Sanger Institute.

[Sigurgeir Olafsson @MutationalSig]

Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients
https://t.co/SRbQAgcdAE

[Sigurgeir Olafsson @MutationalSig]

@sciencejannat @CellGenomics Congratulations Jannat! It took a lot of perseverance to get this out I imagine. Great work 👏

[Sigurgeir Olafsson @MutationalSig]

@alehins @PREDICTIBD Tillykke!

[Bjarni Halldórsson @bvhalldorsson]

UK biobank WGS 500k data available
https://t.co/D0JQMx0m47

[Sigurgeir Olafsson @MutationalSig]

Germline variants at 25 loci influenced the risk of developing CH. These do not show association with cardiovascular disease and Mendelian Randomization further gave no indication that they increase the risk of cardiovascular disease.

[Sigurgeir Olafsson @MutationalSig]

Check out this work by my @decodegenetics colleagues, Simon Stacey and Florian Zink, on clonal hematopoiesis that appeared in @NatureGenet today:
https://t.co/DcXGm0c0Lq

They show that you can call CH based on a mutation "barcode" in the absence of a typical driver mutation.

[Sigurgeir Olafsson @MutationalSig]

Very importantly, this large-scale study of two biobank scale cohorts failed to find evidence that clonal hematopoiesis causes heart disease. It suggests that the associations previously reported are the result of confounding between smoking behaviour and these phenotypes.

[Sigurgeir Olafsson @MutationalSig]

@jogleeson_ucsd @naxerova It really was an amazing meeting! So honored to have been invited. It was great to meet you all. Insightful discussions led to a lot of new ideas.

[Sigurgeir Olafsson @MutationalSig]

Many thanks to all the co-authors. @anderson_carl, @andrewrjlawson, @Axel_R_Huber, @imartincorena and others not on twitter. It was a pleasure working with you on this project.

[Sigurgeir Olafsson @MutationalSig]

Today on #WorldPsoriasisDay, please check out our manuscript that is just out in @NatureGenet about somatic evolution in the skin of psoriasis patients
https://t.co/SRbQAgcdAE

[Sigurgeir Olafsson @MutationalSig]

The signature also shows a very strong transcription strand bias. This is driven partly by transcription coupled repair but also by transcription-coupled damage, similar to what has been described for SBS16 in the liver.

[Sigurgeir Olafsson @MutationalSig]

@AlexBickMDPhD @AllofUsResearch @dgmacarthur @ceclindgren @timfrayling @minouye271 @nicolesoranzo @GLettre @samrip @ShaiCarmi @jgustavsmith @andganna @PaulLacaze @drjamesware @nickywhiffin Why is the data not available to for-profit organizations as well? Would allowing pharma access not help maximize patient benefit? It's them that actually make the drugs...