I’m incredibly grateful to @psscra for the Pershing Square Sohn Cancer Prize, recognizing our work and enabling an important part of our broader vision to develop personalized cancer prevention strategies 🙏
Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
https://t.co/63pYd3UalF
We're in this week's Nature! We propose a model of how a cell learns by running an evolutionary algorithm: exploring different gene-regulatory combinations and using feedback responses to stabilize those combinations that reduce stress levels.
Full text: https://t.co/yQYic2owl0
Only half of esophageal adenocarcinomas (EACs) are associated with background Barrett esophagus (BE). New integrated epidemiological & molecular data from @RFitzgerald_lab reinforces commonalities between the two reiterating that BE is universal precancer.
https://t.co/zykxPzzEQW
Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] https://t.co/8kQZ0NWl7X
latest from the lab --> how we used whole genome passenger somatic mutation patterns 🧬 to trace the origins of never-smoker lung adenocarcinoma (LUAD) to cells of the proximal lung 🫁 @NatureGenet https://t.co/jqNdVSdZ9z 1/🧵
Honored to be part of the 2025 class of #PackardFellows ✨ and deeply grateful to the Packard Foundation for supporting bold science that advances knowledge and real-world impact 🌎🧬🙏 https://t.co/gmQ1JdNtVq
Excited to share our exploration @naturemethods into new horizons opening up in the era of low cost sequencing!
🔥 Deeper sequencing at WGS scale for PPM sensitivity of tumor informed MRD
🔥Duplex sequencing at WGS scale for plasma only exploration of ctDNA
Check out thread 👇
🚨OPEN POSTDOC
POSITION in our brand new lab space by Madison Sq NYC ! 🌆🧬🔬
Do experiments, learn computation, and uncover drivers of a major mutational process affecting >50% of cancers, driving therapy resistance & impacting immunotherapy responses👇
https://t.co/RT7WEtr1Dy
🚨OPEN POSTDOC
POSITION in our brand new lab space by Madison Sq NYC ! 🌆🧬🔬
Do experiments, learn computation, and uncover drivers of a major mutational process affecting >50% of cancers, driving therapy resistance & impacting immunotherapy responses👇
https://t.co/RT7WEtr1Dy