Toni Beltran

Valencià a Barcelona. Mutant proteïnes al @CRGenomica ⚛️🔬🦠

[Toni Beltran @mutatoni]

@AthiNaganathan @BenLehner Thanks!! More to come... 🧬🧬🧬🧬🧬

[Centre for Genomic Regulation (CRG) @CRGenomica]

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @BenLehner and Toni Beltran @mutatoni is out in @Nature.

✍️ Illustration by @QueraltTolosa

[Toni Beltran @mutatoni]

@Albacorp7 Gràcies Alba!! Si passes per Barna avisa eh?! :P

[Ben Lehner @BenLehner]

The genetic architecture of protein stability
by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel
https://t.co/Z4cxr9M4Hm
@CRGenomica @sangerinstitute @ALLOXbio

[Ben Lehner @BenLehner]

Excited to share @AlbertIltirda's randomisation of protein cores at scale: Genetics, energetics and allostery during a billion years of hydrophobic protein core evolution
with @aj4re @CRGenomica @sangerinstitute https://t.co/X0C7coty8j

[Jamie Hackett @hackettlab]

How do chromatin modifications quantitatively impact gene expression?

How do sequence variants or combinatorial marks influence relationships?

We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵…

https://t.co/2p4W0J50Oc

[Jamie Hackett @hackettlab]

The gut microbiome influences metabolites, hormones and immune function

Perturbing gut microbiota therefore impacts homeostasis across somatic tissues

Could it also affect the reproductive system - and even offspring?

See our results👇& tweetorial🧵

https://t.co/lb6w6BjoW7

[Toni Beltran @mutatoni]

@AthiNaganathan @biorxiv_biophys @LindorffLarsen Thanks for sharing! We will definitely include a discussion in the revised version 😊

[Ben Lehner @BenLehner]

@ToniBeltran13 @CRGenomica @sangerinstitute That's the Src kinase domain alone. Here's the allosteric map of the kinase domain in the context of the full-length protein (+ SH2, SH3, SH4 etc).

[Ben Lehner @BenLehner]

Thread by @ToniBeltran13 about the Src kinase allosteric map. And here is one view of the map. @CRGenomica @sangerinstitute

[Toni Beltran @mutatoni]

I'm super grateful to have had the support of all the Lehner lab members, and of course of @aj4re and @BenLehner. We are super excited to expand this approach to other kinases and enzymes next! 🧬🧑‍🔬💻

[Toni Beltran @mutatoni]

I’m super happy to finally share what I have been up to the last few years at the @BenLehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.

[Ben Lehner @BenLehner]

The allosteric landscape of the Src kinase. Amazing work from @ToniBeltran13 with @aj4re https://t.co/U6qmtfWtqF @CRGenomica @sangerinstitute

[Toni Beltran @mutatoni]

This complete allosteric map also allows us to take an unbiased look at the surface of the kinase. Many surface pockets are enriched in inactivating allosteric mutations, and we think these might be interesting sites to target with drugs in the future! 💊

[magdatopolska @magdatopolska1]

Excited to share a new, MUCH IMPROVED version of our deep indel mutagenesis (DIM) manuscript:
https://t.co/ukxVOsYSzs
See the thread below for details.

[Toni Beltran @mutatoni]

@PSarkies Thanks a lot Peter! deep epimutational scanning next? 😜

[Taraneh @taraneh_z]

Very happy to share what I've been working on in Barcelona with @BenLehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)