Rowdy Ramsay

market speculator

[Bryan Johnson @bryan_johnson]

I think magic mushrooms are a longevity therapy.

After seeing the data from two doses, psilocybin offers unique longevity effects that complement the best performing therapies I’ve done to date including sauna, hyperbaric oxygen therapy, sleep, nutrition and exercise.

This was the most quantified psychedelic experiment ever done.

It's noteworthy that even though many of my biomarkers are already in the 99th percentile optimal, psilocybin still showed multi-system improvements. Something other therapies have not been able to accomplish.

Of course, my data will need to be replicated and the magnitude and duration of benefits needs further assessment.

Here is what we learned:

0. We observed broad benefits across mental, hormonal, metabolic, and anti-inflammatory systems. Since these are the primary drivers of biological aging, this multi-system signal offers a compelling case for longevity potential.

1. Psilocybin may be a metabolic reset button for the brain. We expected brain changes, but not a potential metabolic breakthrough. My blood sugar control improved from the top 2% of the population to 0.2%, better than 99.75% of 18-25 year olds.

2. Psilocybin reduced my inflammation (hsCRP) to below detectable levels one week post dose.

3. Psilocybin calmed my body and mind.  Lower cortisol, and an inhibited HPA-axis in the days following the dose. Both my cortisol and DHEA (another product of the adrenal cortex) dropped 42% and 45% respectively, indicating an overall adrenal reset associated with rest and recovery.

4. Psilocybin increased brain plasticity, desynchronized default networks, resulting in enhanced creativity, playfulness, and openness, with reduced mental rigidity.

5. A second psilocybin dose built on the first and pushed sensory integration even further, increasing primary sensory-motor integration beyond the peak of the first dose.

6. Psilocybin induced an intense blend of joy, deep insight, and a subtle hint of melancholy,  also detectable by thermal biometrics.

We had two significant firsts in this experiment:

0. First documented human CGM-based observation of improved post-psilocybin glucose control.

1. First-ever thermal profile of an intense psilocybin dose.

Pending data:
+ Telomere length and relative telomerase activity (telomere regeneration capacity).

+ Epigenetic measurements

+ Microbiome

Experiment details

Here are more details about my two magic mushrooms trips, doses, and the results of my measurements up to date.

I had two doses of dried and powdered Psilocybe Cubensis (Variety  B+) mushrooms, three weeks apart.

First dose Nov 9th: 4.67g (24.98 mg psilocybin and 3.5 mg psilocin). Setting: relatively private, only with @_katetolo and the accompanying guide.

Second dose Nov 30th: 5.35 g (28 mg psilocybin and 4 mg psilocin). Setting: relatively open, with friends and family joining virtually, and live streaming.

I dissolved the first dose in orange juice but used lemon juice for the second, for the following reasons:

+ Lemon is more sour, which delays the conversion to psilocin and breakdown in solution, thus preserving more total psilocybin to be activated to psilocin after ingestion.

+ Lemon juice has, on average, 70% less sugar and 45% less calories, making it less disruptive to my otherwise faster state throughout the journey, and leading to a much lower glucose peak.

Rewired brain connectivity

Kernel Flow measurements after the first dose showed shifts in my brain connectivity mirroring my subjective experience, and the mapping of 5-HT2A receptors.

These included the inhibition of my default networks and command centers including prefrontal context and a shift towards increased functional connectivity and hyperintegration between primary motor, sensory, auditory, and speech integration. This coincided with an entropic brain pattern, more open, flexible, exploratory, and creative, indicating a shift from aged and rigid to open youthful brain state.

The baseline measurement before the 2nd dose indicated a strong lasting effect from the first dose 3 weeks earlier, post-peak measurement after the 2nd dose indicated an additive effect of the 2nd dose, with a brain entropic and increased primary sensory-motor integration beyond the peak of the first dose. Most notable was the increased intensity of integration and activation of the auditory, speech, and language networks, coinciding with the second dose being joined by family, friends, where I enjoyed expressing and describing my feelings.

Face and body thermal biometrics

We produced the first ever face and upper body thermal map of a magic mushroom journey.

A core temperature increase of 1.5–2°F suggests an intense psychedelic experience, likely due to a large psilocybin dose (28 mg psilocybin, 32 mg combined psychoactive content).

Heat was redistributed to the core, consistent with 5HT2A–mediated autonomic activation, which can include increased sympathetic tone, lasting through the peak and early post-peak of the experience.

Facial and body thermal shifts indicate a potential blend of intense joy, insight, and subtle sadness or melancholy.

First documented human CGM-based observation of improved post-psilocybin glucose control

Psilocybin appears to have triggered a previously unknown metabolic reset in my brain, an unexpected breakthrough.  Comparing the 3-day periods before and after the psilocybin dose:

My blood glucose control dramatically improved, moving from the top 2% to the top 0.2% of the entire population, including healthy 18-25 year olds.

+ 8% reduction in mean blood glucose, reaching 80.84 mg/dL, a new personal best.

+ 11% reduction in fluctuation, indicating smoother glucose peaks and improved control.

+ This single session reduced my estimated HbA1c 0.3 6.8% from 4.7% to 4.4%, (a relative reduction of 6.8%).

+ Durability: The positive effect was still as strong on Day 3 post-dose as it was on Day 1.

Note: A long trip to China on Day 4 interrupted this streak. We plan to explore the full durability of this effect with the next dose.

This matters because we treat diabetes and metabolic dysfunction with chronic daily medication (Metformin, Insulin, GLP-1s). This data suggests that a neuroplastic event might have downstream effects on the liver and pancreas that mimic or exceed these drugs.

Systemic inflammation was below detectable levels

Five days after the first dose, my hsCRP dropped to an undetectable level (below 0.15 mg/dL), representing a 35-100% decrease from the pre-dose level of 0.23 mg/dL.

Three days post-second dose, hsCRP was barely detectable at 0.18 mg/dL, which is still a 22% drop from the initial baseline.

Tumor necrosis factor-alpha (TNF-alpha) remained unchanged between baseline and post-second dose. It was not measured after the first dose.

For the next dose, we will measure a wider panel of inflammatory markers, including IL-6 and IL-10, and cover several time points post-dose.

High cortisol at Peak, low cortisol and stress the following week

Cortisol spiked at the peak of the acute phase, followed by a decline in morning cortisol levels and HPA-axis inhibition, consistent with a relaxed "after-glow" phase in the week following the trip.

My cortisol spiked to 3x morning spike levels four hours after taking the mushroom dose. Levels returned to normal nightly baseline before bedtime.

Five days post-dose, my morning cortisol levels had dropped by 42%, and DHEA-S (a marker of adrenal activity) also dropped by 45%, aligning with inhibited HPA-axis and adrenal activity.

Estradiol levels increased by 200%, consistent with preliminary published evidence that peripheral 5HT2A activation increases cortisol by driving aromatase expression.

[Concerned Citizen @BGatesIsaPyscho]

“The Bill & Melinda Gates Foundation started funding a Vaccine for Alpha Gal Syndrome”

“We’ve got Tick infestations sweeping the Countryside infecting thousands of people”

Nobody is even surprised at this point.

[Nicolas Hulscher, MPH @NicHulscher]

Just 4 months before the Bundibugyo Ebola outbreak, Bill Gates’ vaccine enterprise CEPI gave Moderna and Oxford $26.7 MILLION to develop Bundibugyo Ebola mRNA shots....

Yes... the EXACT same Ebola strain.

This is what happens when pandemic profiteers aren't held accountable.

[Dr Singularity @Dr_Singularity]

The world is about to accelerate beyond imagination.

A multi agent system for automating scientific discovery is here.

AI Co-Scientists is here.

Both papers published 2 days ago.

Two huge steps into makig scientific progress 100x - 1000x faster than today.

[Valerie Anne Smith @ValerieAnne1970]

BILL GATES’ MICRONEEDLE mRNA PATCH IS HERE

Meet the new “vaccine” that doesn’t just jab you — it permanently tattoos your body with modified mRNA AND quantum-dot QR codes.

One painless patch on your wrist (or wherever) dissolves, floods you with mRNA, and embeds scannable biotech markers that last years — possibly forever.

No phone needed.
No card.
No paper passport.

Just scan your skin at the store, airport, or restaurant and the system instantly knows your “vaccine status,” batch number, and compliance level.

This is the biological control grid planned for the next plandemic — a permanent digital prison under your skin.

They’re not hiding it anymore.

Your body is the barcode.

Wake up.
Resist.

[Healthy Alfred 🏄🏻‍♀️ @HealthyAlfred]

BPC-157 fixed injuries that doctors called permanent.

Severed nerves — REGREW.
Torn ligaments — REBUILT.
Destroyed gut lining — REVERSED.
A punctured cornea — HEALED.
Parkinson’s tremors — GONE.

Not in years. In WEEKS.

→ regrew SEVERED nerves
→ reattached tendons to BONE
→ 90% knee pain relief in HUMANS
→ reversed gut damage from Advil
→ healed a PUNCTURED eye
→ reversed Parkinson’s and prevented DEATH
→ no lethal dose EVER found

A 15-amino-acid peptide from your own stomach juice. Your body makes it. Just not enough to finish the job.

That shoulder. That knee. That gut. Every injury you still carry is a repair your body started and never completed.

500+ published studies. Your doctor has never mentioned it.

BPC-157 finishes what your body quit on.

I take Barrier Health’s oral tablet BPC-157 personally. No injection. No prescription. Code ALFRED saves you 15%. I’ll drop the link below.

[Dr. Tau Braun @drtaubraun]

We are heading towards mass die off.

The academic and pharmaceutical insider that has correctly predicted this is @GVDBossche.

However, he is incorrect on mechanism. It is not going to be caused by a mutating SARS-CoV-2 virus. SARS-CoV-2 does not exist.

They injected a 19 nucleotide kill switch into billions of people.

3 ways to trigger the kill switch.

1. EMF around 100 gigahertz
2. Acoustic EMF (Frey effect)
3. Geoengineering (sun dimming)

The combination is deadly.

Switch awakens primitive copper resistant fungi - leading to overgrowth.

Resilient toxin producing biofilm forms. Gram negative bacteria thrive and kill off gram positive bacteria like Bifidobacterium. Natural biowarfare starts. Bacteria and fungi in a full war. Parasites love it. It means resources.

Netosis is the bodies answer. So the clotting begins, then the amyloids, then the worst Prions.

Triple Threat of Spike Protein: Hibernation-Torpor, Envenomation, Immune Tolerance. If the body cannot turn any of those circuits off - death is inevitable.

Now this always leads to the question so what do we do about it.

1) If you are still in denial, slap yourself in the face - I'm not there to do it for you.

2) Start empowering those that are trying to help you and have been warning you for 6 years

3) Demand accountability - there is only a small group of us doing this - that includes holding President Trump accountable for the military operation called Operation Warp Speed. If he was lied to he needs to start tribunals immediately and arrests and prosecution for treason needs to happen swiftly.

4) Demand an end to geoengineering and proposed projects. Stop 6G research and development.

5) Move life to analog. Group meetings in person. Support local businesses and farms. Less digital exposure. Connect with life and nature again. Rewild.

[Nicolas Hulscher, MPH @NicHulscher]

Senator Ron Johnson is correct — COVID-19 mRNA "vaccines" are NOT vaccines.

They are synthetic gene-transfer platforms that hijack vital organs to mass-produce lethal, non-human proteins.

Here’s how they really work 👇

[Healthy Alfred 🏄🏻‍♀️ @HealthyAlfred]

Aged mice received ONE peptide — FOXO4-DRI — for 3 weeks.

Fur grew back. Kidneys healed. Fitness returned.

The aging REVERSED.

(PMID: 28340339 — published in Cell)

Right now there are MILLIONS of dead cells rotting inside your body.

They can’t divide. They can’t repair. They REFUSE to die.

They just sit there POISONING every tissue around them.

Scientists call them zombie cells. The single biggest driver of aging ever discovered.

→ joints rotting with inflammation
→ skin collapsing as collagen disappears
→ wounds taking weeks instead of days
→ testosterone crashing year after year
→ energy vanishing no matter what you try

Your doctor calls this “getting older.” It’s not.

FOXO4-DRI is a synthetic peptide your body can’t break down. It does ONE thing.

Zombie cells survive by TRAPPING p53 — your body’s kill switch. FOXO4-DRI frees it. The zombie cell self-destructs.

Healthy cells don’t use this trick. Untouched.

Every day you wait, more zombie cells accumulate. More tissue dies.

Your body has a self-destruct button for broken cells.

Age jammed it. FOXO4-DRI unjams it.

The studies are below.

[Cryptic Trades @CrypticTrades_]

🚨U.S. debt relative to GDP has reached the highest level in over 80 years.

This is the first major piece to fall that will lead us to the Roaring 20’s.

A Thread 🧵

[Bilu Huang @BiluHuang]

All aging phenomena are associated with p53.

Then, during cellular senescence, why do the synthesis rates of ATP and total protein decline, and how does the gene expression profile alter? The author proposes that these changes are directly or indirectly linked to the tumor suppressor protein p53. This is because p53 levels gradually rise in all cell types throughout senescence, and a wide range of aging manifestations are closely related to p53. For instance, p53 inhibits mitochondrial ATP production; it also indirectly reduces histone acetylation levels. Reduced histone acetylation tightens the binding between histones and DNA, impairs DNA transcription, and consequently slows the overall rate of protein synthesis.

Senescent cells secrete a panel of inflammatory factors collectively termed the senescence‑associated secretory phenotype (SASP), including IL‑1β, IL‑6, IL‑22 and other mediators. The expression of IL‑1β and IL‑6 in senescent cells is mediated by p53[9]; p53 binds to the IL‑22 promoter to enhance IL‑22 gene transcription[10]. Additionally, p53 activates its downstream target gene p21, and p21 further promotes SASP production by reducing the phosphorylation of Rb protein[11].

Downregulated expression of DNA repair genes leads to increased genomic instability and progressive accumulation of mutations. In other words, senescence of cells and the immune system in the organism results in the buildup of mutated DNA and aberrant cells, rather than the accumulation of mutations driving organismal aging[4].

Irreversible cell cycle arrest, a hallmark of senescent cells, is also triggered by p53. p53 upregulates the downstream genes p21 and p16, which inactivate Rb protein — an essential regulator of DNA replication — and block cell cycle progression[12]. Accordingly, simple pharmacological inhibition or genetic knockout of p53 enables unlimited cell proliferation[13‑14]. These findings indicate that p53 acts as a master regulator governing cellular senescence.
The alterations in gene expression profiles during cellular senescence are characterized by widespread downregulation of most genes, alongside a small subset of genes with markedly elevated or suppressed expression. Such transcriptional remodelling drives age‑related changes at both the cellular and organismal levels, and governs developmental progression and aging. Therefore, age‑dependent shifts in gene expression profiles essentially represent a genetic program that orchestrates organismal development and senescence.

In senescent cells, the minority of upregulated genes predominantly exert detrimental effects on cells and the whole organism, with SASP factors serving as a typical example.

[iamyesyouareno @iamyesyouareno]

They just worked harder, you know.

[Resurekt @0xresurekt]

The Bear Flag ain't flagging

[Resurekt @0xresurekt]

Everything is in a Bull Market

But Bitcoin needs to be in a Bear Market

Why?

Because it's not October yet

[pepa🌙 @moonshilla]

GM 🫣

[⚡Shane_S⚡ @shanesek1]

@PandaSoulBoy The reality is that every market is a positioning and psychology game... big money moves against crowd expectations...create the move, attract liquidity, then exit into it.

Basically, it's
Front end = news and narratives.
Back end = liquidity and human behaviour.

[Osemka @Osemka8]

$GOLD is a perfect example of how rigged the game is

It is no coincidence that both @binance and @coinbase both opened metals trading on their platform 1 day from each other and the top was in a day after. It's all coordinated.

Now we cal start talking about the top for gold being in with this ABC into 0.786 Fib

Top on Gold = good for crypto

[Juice @joshj100x]

Alt Season.

Do you understand yet???

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

2026 is the year capital flows into biotech.

2012 - CRISPR discovered, nobody knows what to do with it
2018 - Gene therapy costs $2M per treatment, completely unscalable
2020 - mRNA works but gets written off as a COVID fluke
2023 - AI eats software, biotech still stuck in 20-year timelines
2024 - Autonomous labs emerge, longevity gets institutional backing
2025 - FDA shifts, manufacturing costs drop 40%, DeSci bypasses gatekeepers

2026 - AI running 36K experiments autonomously, gene therapy costs dropped 40%, FDA fast-tracking, €2.5M crowdfunded in 72 hours, and biology just hit software velocity

bio/acc.

[Nicolas Hulscher, MPH @NicHulscher]

The evidence is now undeniable:

1. First Study Finds COVID-19 "Vaccines" Increase Risk of Multiple Cancers: https://t.co/JyfJ8EEn54

2. Second Study Finds COVID-19 "Vaccines" Increase Risk of Multiple Cancers: https://t.co/YZzOUkX6AT

3. Systematic Review Documents 300+ Peer-Reviewed COVID Shot Turbo Cancer Cases Across 27 Countries: https://t.co/ynjU6DXjvq

4. mRNA "Vaccine" Genomic integration Demonstrated: https://t.co/yHiX6isC78

5. 17 Ways mRNA Shots Induce Cancer, According to 100 Studies: https://t.co/Es15qEsz5m

6. mRNA Injections Induce Severe, Long-Lasting Genetic Disruption Linked to Cancer and Chronic Disease: https://t.co/A9LTptl0mJ

7. mRNA "Vaccine" Spike Protein Detected in Both the Cytoplasm and Nuclei of Metastatic Breast Cancer Cells: https://t.co/dRoWfZJQX0

8. First Peer-Reviewed Paper Defines COVID-19 Vaccine-Induced Turbo Cancer: https://t.co/3gfYKnv1pe