An unethical, four-decade syphilis study that ended in 1972 is a real and present concern for black people in Tuskegee, Ala. as they consider whether to get Covid-19 vaccine shots. From @littlewern@wsj https://t.co/A2uJytSJI1
What if #philanthropy was like, "Here's your research grant (c3). Here's your R&D PRI (co-op, etc) to test your hypothesis. Here's your 2nd research grant to share findings." Am I not just asking for a "from inception to innovation" funding for THE SCIENTIFIC METHOD in #startups?
1/ CDC putting aerosols under “common routes of spread” of #covid19 is a significant shift.
We have been saying “wear a mask” and “6 feet apart” for months.
Cloth masks are not designed to block aerosols. And 6 feet apart may be insufficient, esp indoors w/ poor ventilation.
Now, with all 3 of the leading Phase 3 vaccine trial protocols released, we can see their design, assumptions, endpoints and major differences. I've summarized those here and infections (events) in the short🧵below
https://t.co/fTlKiACI4X
C.D.C. Testing Guidance Was Published Against Scientists’ Objections. A controversial guideline saying people without Covid-19 symptoms didn’t need to get tested for the virus came from H.H.S. officials and skipped the C.D.C.’s scientific review process.
https://t.co/30Cl9lz2xF
Science must always be the driving force in communicating to the public during a health crisis. Right now trust is being undermined because the integrity of science is being compromised by politics.
https://t.co/Q52UKEHlJo
Really important concept below.
Example: Remdesivir trial was stopped early. https://t.co/u7036ubcJK
I understand why, but scientifically, had it continued, we would know if R really did reduce mortality. (hazard ratio for death, 0.70; 95% CI, 0.47 to 1.04)
Tough calls.
My team are so mighty, so positive, so skilled, so glorious! Now, where's the open competitive funding for teams that deliver code, and researchers who know how to code, as well as papers? Does UK research really still have to live in the 1990s?
Replication is fundamental for all work in science, no less for the results of clinical trials. That's why it's good to see the survival benefit of dexamethasone for severe #COVID19 replicated by a @WHO meta-analysis of 7 corticosteroid trials today
https://t.co/ejolZfsJUl
In this Nature piece on academic citation tools I describe punching myself in the face through sheer rage at bad software. It doesn't cover a really important key issue, tho: why are we still using citations instead of hyperlinks? Micro-tiny-thread....
https://t.co/Z7zpMZdEXe