NanoCap(Team9)

[NanoCap(Team9) @NanocapTeam9]

@ThakurSthakur11 @NU_ChemE Thanks for the response! We wanted to take an existing process that was much more environmentally friendly and cheaper than the existing process for developing nanoparticles. Green tea was a great option because it works as a surfactant as well in our process!

[NanoCap(Team9) @NanocapTeam9]

Hi everyone! We at Nanocap are excited to share our #CHME4703Poster on green synthesis of silver nanoparticles for photothermal therapy of cancerous tumors! Check out our poster below! @NU_ChemE

[NanoCap(Team9) @NanocapTeam9]

@Profess88700345 @NU_ChemE The addition of a targeting ligand requires the use of synthetic particles which interferes with our mission. Furthermore, the particles should not agglomerate widely in healthy cells as it would in tumor furthermore the light therapy is specifically targeted at the tumor site.

[NanoCap(Team9) @NanocapTeam9]

@JacobHe18314812 @NU_ChemE Good question! To be completely honest, we aren’t completely positive why 1.5 hrs had a low concentration. We weren’t able to run the experiments ourselves, but it could be that some of the nanoparticles were lost when the liquid was drained since this reaction is irreversible.

[NanoCap(Team9) @NanocapTeam9]

@always_sunny19 @NU_ChemE Thanks! While our reaction itself is only 2 hours, we have a lyophilization process that we estimate will take 1-2 days. So to take into consideration cleaning, we estimate running 2 batches per week. We’re also considering expanding our yield to consider other types of cancer.

[NanoCap(Team9) @NanocapTeam9]

@MilkyWayChemE @NU_ChemE Hi Milky Way Engineering,
Very interesting project. I've never heard of Lab-grown milk. I was curious what your run-time is? How often will the plant be shut down to clean reactors and other equipment to insure purity of product?

[NanoCap(Team9) @NanocapTeam9]

@Group1034236629 @NU_ChemE Hi NCC, your poster looks great! You mention in that your simulation showed centrifugation is insufficient in reducing moisture and suggest ultrafiltration could be a sufficient solution. Why not use a dryer to remove the moisture?

[NanoCap(Team9) @NanocapTeam9]

@CHME4703GROUP20 @NU_ChemE Awesome poster! I was wondering how would you control the plastic mixture feed concentration? If that concentration varies, would that affect your process efficiently?

[NanoCap(Team9) @NanocapTeam9]

@CamelinaSativa @NU_ChemE In regards to your other question, it’s a relatively small process with a reaction time of about 1 hour and downtime of about 2 days to allow for lyophization. We plan to run 2 batches/week and do not anticipate having trouble meeting our goal yield. We’re estimating 4 operators

[NanoCap(Team9) @NanocapTeam9]

@CamelinaSativa @NU_ChemE Good question! Our dosage per patient is approximately 93.4 mg and we are hoping to sell at $20/mg. Not only is this competitive compared to chemotherapy costs, but our preliminary estimates expenses of just under 7 million/year, so we expect to make a profit.

[NanoCap(Team9) @NanocapTeam9]

@WillitsLab @NU_ChemE Thanks for the feedback! Regarding your question, other plant extracts have different reducting biomolecules and green tea doesn’t need any extra surfactant for the reduction reaction, which is why we chose it in particular!

[NanoCap(Team9) @NanocapTeam9]

@Nosym_Pharma @NU_ChemE Great question! Our reactants, particularly the tea extract, are relatively cheap. While we are still estimating our overall equipment and production costs, we have minimal large scale equipment and anticipate being able to sell our product at a competitive price of $20/mg.

[NanoCap(Team9) @NanocapTeam9]

@AsteridBio @NU_ChemE The byproduct C22H14O11 will be existing in our process at low concentration, therefore we will be able to control the exposure to benzoquinone through safety measures.

[NanoCap(Team9) @NanocapTeam9]

@AsteridBio @NU_ChemE This makes UV-Vis a valuable tool for identifying, characterizing, and studying nanomaterials. For our project, silver nanoparticles absorb light in NIR spectra at 419 nm to 429 um, thus a peak in absorbance shows the presence of NPs in solution.

[NanoCap(Team9) @NanocapTeam9]

@AsteridBio @NU_ChemE UV-Vis measures the scatter and absorption of light passing through a sample. Nanoparticles have unique optical properties that are sensitive to the size, shape, concentration, refractive index and etc. near the nanoparticle surface.