Another huge medical achievement from our very own @UHN 🇨🇦🔥
A Toronto man lived with HIV for 27 years. Then he got leukemia and that diagnosis may have just cured him of both.
His doctors found a bone marrow donor carrying CCR5-Δ32, a rare mutation in ~1% of people of European descent. HIV hijacks immune cells through the CCR5 receptor. If you don't have it, the virus has no door.
The transplant replaced his entire immune system with one HIV can't infect.
He stopped antiretroviral therapy in July 2025. As of today, HIV is undetectable by the most sensitive assays available. No viral reservoir. No immune response to HIV. Nine months clean.
He would be the 11th person in history to possibly be cured of HIV.
HIV cure is possible. We just proved it again at @UHN
Proud of the team at @UHN and @UofT !
Source: https://t.co/zH1fIfVubV
2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/ SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults
https://t.co/iAxNQtYgVh
Adding prothrombin complex concentrates to automated dispensing cabinets in the ED with bedside preparation results in significantly faster administration times when reversing warfarin and factor Xa inhibitor associated ICH
https://t.co/gAexM7Jqis
👀 #Pseudomonas spread from lung to gut in hospitalized patients - “These findings suggest that colonization of the lower respiratory tract should be considered a risk factor for gut-derived sepsis in high-risk patients, particularly in the ICU.” https://t.co/ezXsvd47ZD
Andexxa — the emergency reversal medication for apixaban (Eliquis) and rivaroxaban (Xarelto) — will be discontinued Dec. 22. Hospitals will continue to use 4-factor PCCs, a widely used alternative. Your anticoagulant isn’t changing. For questions, talk with your doctor.
It took us a while to recognize euglycemic diabetic ketoacidosis (euDKA) in patients treated with Na-glucose cotransporter-2 inhibitors. It seems that we may have to be on the lookout for euDKA in patients treated with glucagon-like peptide-1 receptor agonists (#Wegovy#Zepbound)
New Pub! 🩺
Of ~50,000 calcium channel blocker overdoses, only 1.2% had hyperglycemia—but those patients were ~22× more likely to have severe outcomes or death.
Hyperglycemia is uncommon but a red flag in CCB toxicity.
📖 https://t.co/oH5HyeHMPk
#Toxicology#MedTwitter