Natalie Chaput (she/her)

Yogi, dog lover, pharmacist | interested in ID, critical care & toxicology | PGY1 pharmacy resident | U of T PharmD 2T5 | QU alumni

[Bo Wang @BoWang87]

Another huge medical achievement from our very own @UHN 🇨🇦🔥

A Toronto man lived with HIV for 27 years. Then he got leukemia and that diagnosis may have just cured him of both.

His doctors found a bone marrow donor carrying CCR5-Δ32, a rare mutation in ~1% of people of European descent. HIV hijacks immune cells through the CCR5 receptor. If you don't have it, the virus has no door.

The transplant replaced his entire immune system with one HIV can't infect.

He stopped antiretroviral therapy in July 2025. As of today, HIV is undetectable by the most sensitive assays available. No viral reservoir. No immune response to HIV. Nine months clean.

He would be the 11th person in history to possibly be cured of HIV.

HIV cure is possible. We just proved it again at @UHN

Proud of the team at @UHN and @UofT !

Source: https://t.co/zH1fIfVubV

[Dr. Prarit varshney @prarit_v]

Piperacillin + Tazobactam

[NASA @NASA]

@alltooriah Tell your cat the Artemis II crew said pspsps

[Natalie Chaput (she/her) @NatChaput]

@ABsteward Did a bunch of MDROs get together to write these guidelines? 🫠

[Circulation @CircAHA]

2026 AHA/ACC/ACCP/ACEP/CHEST/SCAI/ SHM/SIR/SVM/SVN Guideline for the Evaluation and Management of Acute Pulmonary Embolism in Adults
https://t.co/iAxNQtYgVh

[Muhammad Qudrat Ullah, MD @QudratUllahRana]

💊 Anticoagulation simplified:
✔️ DOACs > VKAs
✔️ LMWH > UFH (unless instability or procedures expected)
Less bleeding.
Less ICU time.
More consistency.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🔥Just published 🔥
ESCMID Clinical Guidelines on the Evaluation and Management of a Reported Antibiotic Allergy #IDXposts
https://t.co/E1JJoaNIvu

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

🆕🔥 Review article
Filling the Gaps: A Review and Update on Beta-Lactamase Inhibitor Combinations #IDXposts
https://t.co/Zgv16Bba2Z

[Nick Panos @NG_Panos]

Adding prothrombin complex concentrates to automated dispensing cabinets in the ED with bedside preparation results in significantly faster administration times when reversing warfarin and factor Xa inhibitor associated ICH

https://t.co/gAexM7Jqis

[Natalie Chaput (she/her) @NatChaput]

👀 #Pseudomonas spread from lung to gut in hospitalized patients - “These findings suggest that colonization of the lower respiratory tract should be considered a risk factor for gut-derived sepsis in high-risk patients, particularly in the ICU.” https://t.co/ezXsvd47ZD

[NBCA @StopTheClot]

Andexxa — the emergency reversal medication for apixaban (Eliquis) and rivaroxaban (Xarelto) — will be discontinued Dec. 22. Hospitals will continue to use 4-factor PCCs, a widely used alternative. Your anticoagulant isn’t changing. For questions, talk with your doctor.

[IMCrit @IM_Crit_]

It took us a while to recognize euglycemic diabetic ketoacidosis (euDKA) in patients treated with Na-glucose cotransporter-2 inhibitors. It seems that we may have to be on the lookout for euDKA in patients treated with glucagon-like peptide-1 receptor agonists (#Wegovy #Zepbound)

[Dr. Glaucomflecken @DGlaucomflecken]

I’m sorry, ventricular fibrillation flare-up?

[Ryan Feldman (empoisonpharmd.bsky.social) @EMPoisonPharmD]

New Pub! 🩺

Of ~50,000 calcium channel blocker overdoses, only 1.2% had hyperglycemia—but those patients were ~22× more likely to have severe outcomes or death.

Hyperglycemia is uncommon but a red flag in CCB toxicity.
📖 https://t.co/oH5HyeHMPk

#Toxicology #MedTwitter

[Ryan Feldman (empoisonpharmd.bsky.social) @EMPoisonPharmD]

In case you were wondering, yes, even the HBO show the Pitt knows Andexxa does not work

🫡 to whatever EM PharmD consultant they have for the show

[Mark Lewis, MD, FASCO @marklewismd]

Gram-negative

[Austin Camp @austincamp]

“Sure, we can d/c vanc”

The pharmacist:

[Scott Dietrich @PCC_PharmD]

New study in press comparing efficacy and safety of DOACS vs warfarin in cancer pts with afib

DOACs better in essentially every outcome measured

[mats 💤 | -115 days 📀 @sixteenthirty3]

robby: I’m having the worst day ever
abbott: i’m gonna jump
mckay: i’m being arrested

whittaker and the rats on the er: #thepitt

[Dr RB @bloodygloves__]

Live scenes from Melbourne 😭😭💀💀
#AustralianGP #AusGP #F1