Nate Lake

I ❤️ you

[Nate Lake @natelake]

@athrix_codes @midjourney is Adobe

[Nate Lake @natelake]

@kiwicopple @supabase It has begun…

[Nate Lake @natelake]

@pitus_ Does a one legged duck swim in a circle?

[Nate Lake @natelake]

@Grimezsz 🩷

[Nate Lake @natelake]

@geerlingguy Excellent review, thanks!

[Nate Lake @natelake]

@BRICSinfo The India immune system is peak though

[Nate Lake @natelake]

@dnapway For the safety patrol haters, preface health risks claims of consuming a bag of Cheetos first

[Nate Lake @natelake]

@dnapway You’re welcome: https://t.co/ot8ShUaWJg

[Nate Lake @natelake]

I’ll look up live Syntocinon and nasal oxytocin listings and rank them by whatever sales data is https://t.co/psYT8ZIMFe company publishes unit sales for Syntocinon nasal. Rank below is by live stock and price listings, not a sales report.
1. Brazil — only market with many stores stocking it Viatris / Mylan. 40 IU/mL, 5 mL. About R$42–55. Needs a prescription.
https://t.co/8awjIXWxxQ
https://t.co/U1S8r0UpEF
2. Switzerland — in stock, prescription Same spray. 40 IU/mL, 5 mL. CHF 45.80 at Zur Rose. Swissmedic 25644.
https://t.co/0cKkkwzKqB
3. US compounded nasal — made to order, no public volume No branded Syntocinon. Pharmacies mix it per prescription. One listing even says non-sterile.
https://t.co/AugqWIAs6L
4. Australia — registered, declared $0 sales TGA still lists it. Sponsor reported zero turnover for 2025–26.
https://t.co/1Z3uUL8PVh
5. US brand Syntocinon — $0, discontinued since 1997
https://t.co/oTDyp2G0xu
Whole oxytocin market is about $123 million. About 78% of that is the injection, not the spray. Nasal is a small slice.

[Nate Lake @natelake]

You want the actual sterile product page, not the Sigma powders. I’ll pull the official link.The sterile one is the prescription injection, not a Sigma powder.
Official label (says sterile on the page): https://t.co/MbpHP7okVB
That is Pitocin, oxytocin injection, USP. Sterile clear liquid. 10 units per mL. Made for IV or muscle injection in a hospital. Used for labor and bleeding after birth.
Maker’s product page: https://t.co/68sZ2MrK2M
Same drug, generic vial. Also sterile.
There is no current US link for a sterile nasal spray. Syntocinon nasal was discontinued.

[Nate Lake @natelake]

You want the cleanest oxytocin used in real human studies, not the lab powders. I’ll find the sterile forms those papers actually used.The sterile product in the bonding papers is not on the Sigma page. Sigma’s powders are labeled non-sterile.
What the studies used
The landmark trust paper is Kosfeld et al., Nature, 2005. They used Syntocinon nasal spray, Novartis. One dose, 24 IU. That is the product behind the “oxytocin increases trust” result.
Syntocinon was a real drug: 40 USP units per mL nasal solution, NDA 012285. Novartis pulled it in the US in 1997 for business reasons, not a safety ban. It is still sold in some other countries. No nasal oxytocin is FDA-approved in the US now.
Sterile ranking
•Most sterile: Pitocin (oxytocin injection, USP). Sterile liquid. FDA-approved. Hospital only, for labor and bleeding after birth. Not a bonding product.
•Used in the bonding papers: Syntocinon nasal spray. Pharmaceutical spray. Discontinued in the US.
•Current US stand-in: a compounded nasal spray from a licensed pharmacy, with a prescription. Made to order. Not FDA-approved for bonding.
•Least sterile: Sigma O3251 and O6379. Same peptide. Explicitly non-sterile. Lab only.
What the papers actually found
Early studies (trust games, reading faces) looked positive. Later big trials were weak. A 290-person autism trial found no benefit over placebo. A pre-registered trust redo also failed. Effects, when they show up, are small and depend on the situation.

[Nate Lake @natelake]

@kunchenguid Fancy that…

[Nate Lake @natelake]

Are frontier audits (at least 50%) in place to make you spend more tokens?

[Nate Lake @natelake]

Are frontier audits (at least 50%) in place to make you spend more tokens?

[Nate Lake @natelake]

@mattpocockuk Bless you

[Nate Lake @natelake]

@steipete Google’s validation has, and always will be ceremonially ridiculous

[Nate Lake @natelake]

@KarolineGeorges more

[Nate Lake @natelake]

My greatest prompt, ever:

Do not stop. Do not ask. Do not wait on a clock.

Finished means: every live agent and every live route works under LAW.md.
A function is done only when a proof on a throwaway schema passes, then you SHIP that SHA.

Run jobs now. If a proof fails, fix the code. Then prove it. Then SHIP. Then the next item.

Keep these four stops until the work itself is proven and shipped:
- no live outbound
- no mint / invite
- no fake auditor verdict
- no guess writes to a...

Dormant flags stay off until that surface has a proof and a SHA. Then flip it on that SHA.

Start with the counts from auditor + 'feature'-extract right now. Then linker first slice. Then the next broken live agent. Keep going until the finish list is green.

I will not answer mid-run. Report only when an item is SHIPPED or a stop is hit.

[Nate Lake @natelake]

@alexeixbt Never felt so naked - she sees right through me

[Nate Lake @natelake]

@Grimezsz been doing this for decades...

[Nate Lake @natelake]

@techbromemes naver