🫁 Unresectable Stage III NSCLC: Current State of the Art.
The management of unresectable stage III NSCLC continues to evolve. cCRT remains the backbone of treatment, while consolidation durvalumab (PACIFIC) and osimertinib for EGFR-mutated disease (LAURA) have redefined the standard of care.
Precision radiotherapy and biomarker-driven strategies are shaping the next era of treatment.
📖 Am Soc Clin Oncol Educ Book
DOI 👉🏻 https://t.co/NCOmck4ZXI
#CánCare #NSCLC #lcsm #thoraciconcology #immunotherapy #precisiononcology
🩺 THE 10 MOST IMPORTANT GI CANCER TRIALS OF #ASCO26
🌟 PLENARY & PRACTICE-CHANGERS
1️⃣ RASolute 302 (LBA5)
Daraxonrasib (RMC-6236) vs chemotherapy in metastatic pancreatic cancer
Can RAS finally become druggable in pancreatic cancer?
2️⃣ CIRCULATE (LBA3500)
ctDNA-guided adjuvant therapy in stage II colon cancer
Potentially the defining trial for escalation and de-escalation strategies.
3️⃣ EMERALD-3
Durvalumab + tremelimumab + lenvatinib + TACE in unresectable HCC
How aggressive should frontline liver cancer therapy become?
🧬 COLORECTAL CANCER PRECISION ERA
4️⃣ BREAKWATER Cohort 3 (LBA3503)
Encorafenib + cetuximab + FOLFIRI in BRAF V600E mCRC
Important real-world sequencing data beyond oxaliplatin-based therapy.
5️⃣ SWOG S2107
Sequencing optimization in BRAF V600E metastatic CRC
A major unmet-need clinical question.
6️⃣ STELLAR Update
Long-term survival update for TNT in rectal cancer
Do pCR gains translate into durable survival benefit?
🎯 GASTRIC, GEJ & RARE GI SUBTYPES
7️⃣ HERIZON-GEA-01 (4010)
Zanidatamab-based frontline therapy in HER2+ gastric/GEJ cancer
Could bispecific HER2 targeting redefine frontline care?
8️⃣ KEYNOTE-811 Mature OS
Final long-term OS update for pembrolizumab + trastuzumab + chemotherapy
Clinicians have been waiting for these mature survival curves.
9️⃣ ATTRACTION-6 Update
Checkpoint inhibitor strategies in advanced gastroesophageal cancers
The IO sequencing debate continues.
🔟 Bezuclastinib + Sunitinib (11500)
Phase III data in advanced GIST
A key resistance-targeting strategy in rare GI oncology.
Which GI abstract will change your clinic most?
#GIOnc #OncTwitter #ASCO26 #PanCan #ColorectalCancer #MedTwitter @ASCO@myesmo@esmo_open@OncoAlert
🎯 Antibody-Drug Conjugates: Expanding Clinical Impact.
ADCs are rapidly reshaping oncology across hematologic and solid tumors, combining targeted delivery with highly potent payloads.
As these agents move into earlier-stage disease and combination strategies, key challenges emerge: biomarker selection, resistance mechanisms, toxicity management, and optimal sequencing.
Next-generation ADC design may further expand efficacy, but careful patient selection will remain essential.
📖 Cell
DOI 👉🏻 https://t.co/3R5JSliiuL
#CánCare #oncology #ADC #precisiononcology #immunotherapy
🚨 THE 15 MOST IMPORTANT TRIALS OF #ASCO26
May 29 - June 2 | Chicago
Which trial are you watching most closely?
🌟 PLENARY GAME-CHANGERS
1️⃣ PROTEUS
Perioperative apalutamide + ADT in high-risk localized prostate cancer
2️⃣ LIBRETTO-432
Adjuvant selpercatinib in RET+ NSCLC
3️⃣ HARMONi-6
Ivonescimab + chemo vs tislelizumab + chemo in squamous NSCLC
4️⃣ RASolute 302
Daraxonrasib (RMC-6236) in metastatic pancreatic cancer
5️⃣ SARC041
Abemaciclib in dedifferentiated liposarcoma
⚡ FRONTLINE & PERIOPERATIVE SHIFTS
6️⃣ KEYNOTE-B15 / EV-304
EV + pembrolizumab vs chemo in MIBC
7️⃣ LITESPARK-022
Pembrolizumab + belzutifan in adjuvant ccRCC
8️⃣ AMBITION
Paclitaxel/bevacizumab ± atezolizumab in HR+ breast cancer
9️⃣ NeoADAURA
Neoadjuvant osimertinib in EGFR+ NSCLC
🔟 A-DREAM
ADT interruption strategies in mCSPC
🧬 PRECISION, ADCs & NEXT-GEN IMMUNOLOGY
1️⃣1️⃣ DESTINY-Breast06
T-DXd expands into HER2-ultralow disease
1️⃣2️⃣ CROWN (7-year update)
Lorlatinib durability in ALK+ NSCLC
1️⃣3️⃣ DeLLphi-312
Tarlatamab in frontline SCLC
1️⃣4️⃣ COMMIT
Atezolizumab + FOLFOX/Bev in MSI-H mCRC
1️⃣5️⃣ IMvigor011
ctDNA-guided adjuvant atezolizumab in bladder cancer
#OncoTwitter #MedTwitter #ASCO26 #CancerResearch @OncoAlert@ASCO@JCOPO_ASCO@OncBrothers
The evolution of resectable NSCLC in one figure. 🫁
From postoperative immunotherapy…
to perioperative strategies with consistently stronger efficacy signals across phase 3 trials.
The field is rapidly redefining the standard of care
@t_mitsudomi 👏👏
@OncoAlert@OncoReporte@MedwatchKate@StephenVLiu@GlopesMd @MedicalwatchHQ