Nicole Hamagami

MD/PhD Student @WUSTLmstp and @Gabel_Lab | Class of 2016 @BrynMawrCollege

[Nicole Hamagami @NHamagami]

Out on @MolecularCell ! We find that H3K36me2 predicts non-CG DNA methylation genome-wide via TAD-level H3K36me2 patterning and conversion to H3K36me3 in gene bodies. NSD1 mediates TAD-level H3K36me2, and NSD1 loss causes changes that overlap with DNMT3A-associated NDDs. A 🧵1/n

[Molecular Cell @MolecularCell]

Online Now: NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons https://t.co/UTsnUVAsRz

[Gabel Lab @Gabel_Lab]

Check out our latest on how specialized neuronal DNA methylation and MeCP2 collaborate with unique long gene structures to help maintain diverse cell-type-specific transcriptomes in the brain!
https://t.co/fEtc4WopSM

[allen institute @AllenInstitute]

The BICCN ecosystem provides a comprehensive resource for the exploration and analysis of cell types in the brain. Check out this guide in @PLOSBiology on its approaches and how to access and use the #OpenScience data and resources.

@USBrainAlliance
https://t.co/hgvoBLNCd9

[Lea Kiefer @LeaKiefer138]

(1/11) Check out our paper https://t.co/E9nK8NXq0b now out in @ScienceMagazine on the role of cohesin-mediated loop extrusion in clustered Protocadherin expression and how that influences neural wiring patterns.

[Ivo Spiegel @Spiegel_Lab]

Paper Alert! A beautiful nature-vs-nurture brain plasticity story, out now in @NeuroCellPress, by Ori Roethler & Eran Zohar, 2 fantastic grad-studs in lab - huge congrats guys, stunning paper! >>1/16 https://t.co/v4NSQxA8eL

[FragileNucleosome @FNucleosome]

@mgnrowland @AVogelCiernia @UBCbiochemistry And for your binging pleasure, we've collated all 113 (and counting) of our recorded seminars into one convenient playlist: https://t.co/dIiEqO1WmN

[Yodai Takei @yodai_takei]

How do subnuclear compartments relate to gene expression and 3D genome organization in single cells? Our new preprint presents two-layer DNA seqFISH+ imaging method to map over 100,000 genomic loci, 17,856 introns, mRNAs, and antibodies in single cells. https://t.co/dUmeXkAFjm

[Nicole Hamagami @NHamagami]

@WUSTLneurosci @Gabel_Lab @MolecularCell Thank you!

[Nicole Hamagami @NHamagami]

@nicklue8 @MolecularCell Thank you Nick! Hope we cross paths again soon! -^^-

[Nicole Hamagami @NHamagami]

Out on @MolecularCell ! We find that H3K36me2 predicts non-CG DNA methylation genome-wide via TAD-level H3K36me2 patterning and conversion to H3K36me3 in gene bodies. NSD1 mediates TAD-level H3K36me2, and NSD1 loss causes changes that overlap with DNMT3A-associated NDDs. A 🧵1/n

[Molecular Cell @MolecularCell]

Online Now: NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons https://t.co/UTsnUVAsRz

[Nicole Hamagami @NHamagami]

@mazzitelli_j @MolecularCell @Gabel_Lab Thank you Jose! 🥰

[Nicole Hamagami @NHamagami]

Huge thank you to all contributors and funding sources for making this project possible. And a special shoutout to @Gabel_Lab members and PI Harrison Gabel for the incredible support and mentorship. 11/n

[Nicole Hamagami @NHamagami]

These changes cause dysregulation in genes with critical function in the postnatal brain that strongly overlap with DNMT3A disorder models, suggesting etiological convergence for NDDs caused by mutation of genes involved in the establishment of the unique neuronal methylome. 10/n