Nikolas Fechner

Views/tweets are my own, retweets do not equal endorsement

[JCIM & JCTC Journals @JCIM_JCTC]

Balancing Molecular Size, Activity, Permeability, and Other Properties: Drug Candidates in the Context of Their Chemical Structure Optimization
https://t.co/I7Wlxu90oX
@nhfechner
#JCIM Vol64 Issue16 #PharamceuticalModeling

[Bülent Kızıltan @BulentKiziltan]

We are hiring: Our AI & Computational Sciences team is looking for creative minds to help us on our mission.

The AI & Computational Science (AICS) team at Biomedical Research is dedicated to revolutionizing drug discovery through AI.

[JCIM & JCTC Journals @JCIM_JCTC]

MELLODDY: Cross-pharma Federated Learning at Unprecedented Scale Unlocks Benefits in QSAR without Compromising Proprietary Information
https://t.co/MbvAYpGgfU
@lew_mervin @TobiasMorawietz @friedo91 @floxedwagen @pschmidtke @nhfechner ...
#JCIM ASAP #MachineLearning #DeepLearning

[Nikolas Fechner @nhfechner]

@dr_greg_landrum Congratulations, Greg! Fantastic news and very well deserved! Thank you for all the great work and all the time and dedication you put into RDKit and its community!

[RDKit @RDKit_org]

Registration for the 2021 RDKit virtual UGM is now open:
https://t.co/6jwmHRSUXA

[RDKit @RDKit_org]

Save the date for the RDKit 2021 UGM: 14-15 October. Yes, it'll be virtual again. :-(

More info and a link to the registration page coming soon.

https://t.co/VQUNVMygys

[Robert Koch-Institut @rki_de]

Version 1.15: 🇩🇪 🤝🇨🇭

Gute News für Grenzgänger und Reisende: Die #CoronaWarnApp und die Schweizer App @SwissCovid sind jetzt verknüpft.

App-Nutzer werden informiert, wenn sie mit einem Nutzer der anderen App in Kontakt waren, der später positiv getestet wurde.

@SAP @BMG_Bund

[Florian Krammer @florian_krammer]

1) The biggest worry for vaccines about the new UK variant is the N501Y mutation in the receptor binding domain. This is also a mutation that appears when SARS-CoV-2 is mouse adapted. A paper looking at that found....

[chrislintott @chrislintott]

A team led by @jgreaves6 have found what might be signs of life high in Venus' atmosphere. They have detected phospine, a gas which on Earth is produced only by life, in quantities they say are too large to be produced any other way. (1/17)

[Sebastian Raschka @rasbt]

"Which Optimizer should I use for my Machine Learning Project?" https://t.co/ea3d92diud

That's a neat quick reference table (personally, I am lazy and usually just stick to ADAM with default settings, works pretty well out of the box most of the time):

[Florian Krammer @florian_krammer]

1) There is a lot of talk about decaying antibodies. I would like to walk you through a few findings about antibodies to SARS-CoV-2 that we put on medRxiv on Friday. Ill do this slowly over the day (while being in nonstop conference calls). But I feel this needs to get out there.

[rapha @rapha_gl]

Have you ever asked yourself "how did research get done before LateX?!"

Oh boy do I have the thread for you… (1/?)

[Trevor Bedford @trvrb]

I wanted to address the hypothesis put forward in Korber et al (https://t.co/ouM4IUyNrd) that the mutation in spike protein D614G causes an increase in transmissibility of SARS-CoV-2 virus. I find this hypothesis to be plausible, but far from proven. 1/16

[Natalie E. Dean, PhD @nataliexdean]

The wonderful @CT_Bergstrom and I wrote something for the New York Times. Herd immunity is insane!

https://t.co/zXD880vsAP

[RDKit @RDKit_org]

Registration for the 2020 RDKit UGM is open!
https://t.co/5pjSABe2Qw

[John Burn-Murdoch @jburnmurdoch]

The numbers are remarkable, and put to bed the idea that Covid-19 is akin to a bad flu season.

You can clearly see that in almost every country, spikes in mortality are *far* higher than what we see from flu etc (grey lines are historical death numbers) https://t.co/EiE5Q3OSmR

[Dr Emma Hodcroft @firefoxx66]

The #EuroMOMO website just got an update & it is now *great* - go take a look at excess mortality due to #SARSCoV2 #COVID19 in Europe in all sorts of interactive ways.

https://t.co/0syfbDVoEW

[Chris Giles @ChrisGiles_]

The England and Wales chart, compared with the previous 50 years shows this is not a normal seasonal flu

Carl Henegan, professor of evidence based medicine at Oxford university, says: "I don’t think we’ve ever seen such a sharp upturn in deaths at that rate"

[Natalie E. Dean, PhD @nataliexdean]

One of my preferred statistics to monitor is the percent of tests that are positive. There are only two ways to drive this number down: test broadly, and have low prevalence of infection. 1/4

[PyCon US @pycon]

Pythonistas come together every year to learn, network & discuss great ideas in person @pycon. That can't happen this year, but we can get together virtually! For the next 4 weeks we'll be posting online content for you to enjoy. Check it out- https://t.co/rI1ZFMAzYG. #pycon2020