Nicolas FAGE

MD, PhD student
Critical Care Physician and Nephrologist - Medical ICU - University Hospital of Angers.

[Nicolas FAGE @nicolas_fage]

5️⃣ 🔎 Guidelines suggest adding vasopressin after a norepi threshold, but data now point to a benefit before this threshold.

🔭 A large RCT is needed to confirm whether early vasopressin at low norepinephrine doses improves outcomes. #Sepsis #CriticalCare #Vasopressin

[Nicolas FAGE @nicolas_fage]

1️⃣🆕 JAMA Study: When to start vasopressin in septic shock?
🔗https://t.co/TZkP56YQdw
��� AI model suggests earlier vasopressin at lower norepiphrine doses → ↓ mortality.
🔎 Consistent with prior data? Let’s review! 👇 #Sepsis #CriticalCare #vasopressin @JAMAJournal

[Nicolas FAGE @nicolas_fage]

4️⃣ Key observational data
📌 Sacha et al. https://t.co/dYkiP5Pqv0
Higher norepiphrine dose at vasopressin initiation → ↑ mortality.
📌 Rydz et al. https://t.co/wXpq579T3z
Early vasopressin (<7h) → ↓ organ failure, ↓ ICU stay, ↓ mortality.

[ANDROMEDA-SHOCK @AndromedaShock]

Just published in AIC. A small study but another brick in the wall! Two important findings: 1. Confirms the previous data from Fage and Monnet, Rai and Hafid Ait-Oufella, and Jacquet-Lagreze about the extraordinary fast kinetics of response of CRT to flow increasing maneuvers.

[Maine-Anjou Research Group @MaineAnjouReg]

Shall we stratify ANCA-vasculitis patients management based on prediction tools? We don't know yet. Before moving forward on this, with @BenoitBrilland and @nicolas_fage, we present a new predictive mortality score for AAV patients https://t.co/eElLeDk7hU. A thread ��1/5

[Hans-Joachim Anders @hjanders_hans]

Now online in @NDTsocial

A predictive mortality score in ANCA-associated renal vasculitis

▶️https://t.co/Y2ldRb6L12

[Zbigniew Putowski @ZPutowski]

Does increasing the dose of norepinephrine (NE) or giving a bolus of fluids improve capillary refill time (CRT) in patients in septic shock? An interesting study was published in @Crit_Care few days ago. 🧵https://t.co/YnwTS7Ot1V

[Nicolas FAGE @nicolas_fage]

Septic shock : volume expansion and capillary refill time
- If CI ↗️ : CRT ↘️ more frequently at the early phase of the septic shock.
- fluid unresponsive : very little chance to decrease CRT
https://t.co/Vm81Lunru3
@Crit_Care @Prof_XMonnet @LaiChristopher2

[Intensive Care Medicine @yourICM]

The forgotten relevance of CVP (& its change over time) monitoring in #ICU
🫀 measurement & normal values
🫀 impact of high CVP values: how could CVP elevation per se cause organ damage?
On @yourICM
🖇️ https://t.co/Mwjv5ZVMUv

[Nicolas de Prost @NicolasdeProst1]

No difference in VAP incidence according to SARS-CoV-2 variant in the dexamethasone era ! See our latest article in Scientific Reports:
https://t.co/DUKOJcAmAI

[Lai Christopher @LaiChristopher2]

Very proud to introduce a new way to detect preload responsiveness in ARDS patients: the PEEP-test!
@Prof_XMonnet @JLTeboul @nicolas_fage @Crit_Care #FOAMed
↘️ PEEP from ≥10 to 5 for 1min (easy 2 perform)
↗️CO≥9% or ↘️PPV ≥1% =preload responsive💧

🔗https://t.co/Z1a6fRZsM7

[Nicolas FAGE @nicolas_fage]

@RangueilAR @EmmanuelRineau @ylauney @BletAlice @ThomasClavierMD @osamaabouarab Bravo @EmmanuelRineau !

[Nicolas FAGE @nicolas_fage]

@JBLascarrou @RussottoVin @SheilaMyatra @AirwayMxAcademy @jducanto Railway !

[Lai Christopher @LaiChristopher2]

Pro/Con use of CVP w/@JLTeboul and @Paul_Mayo #ISICEM2023 @ISICEM
🟢suspect RV failure
🟢perfusion pressure ➡️MAP target
🔴predict fluid responsiveness
⚠️ learn how to measure it properly

[Nicolas FAGE @nicolas_fage]

Quel est l'effet de la noradrénaline et/ou de la vasopressine sur le rein au cours de l'état de choc hémorragique ? effet bénéfique ou délétère ?
Mini revue dans International Journal of Molecular Science
https://t.co/rmtuzCsnXO
@La_SRLF @JeunesSRLF @com_SFNDT @chu_angers

[SRLF @La_SRLF]

Plus que jamais la #SRLF rappelle sa volonté de cohésion et d’entraide.

[Nicolas FAGE @nicolas_fage]

@LandaisMickael Félicitations Mickaël !

[Nicolas de Prost @NicolasdeProst1]

Our article reporting the outcome of critically ill COVID-19 patients with auto-antibodies against type I IFNs in French ICUs is online ! Thanks to all co-authors and @casanova_lab for contributing! @APHP @GHUMondor
https://t.co/jYXTYCoR2b