Nigel Xavier

Creative Strategist. Learning to play the orchestra.

[Nigel Xavier @nigel_xavier_]

When the world falls away from your eyes and reality's ambiance fades away from your ears, you will be left alone with the serenity of a spirit at peace with itself, or with the chaos of a lifetime's inner turmoil.

[Nigel Xavier @nigel_xavier_]

i’ve been really inspired following the Bend2 development. Since March I’ve been thinking a lot about what an agent native language would look like in a world where verification/review is more of a bottleneck than development.

would really love to get your thoughts

https://t.co/3xleDK5dMK

[Fei-Fei Li @drfeifei]

The world of R&D is forking into two paths: the token-abundant research, and the token-starved research. The future is in the former - evidentially, the progress by today's top AI industry teams and neolabs is breathtaking, where researchers’ human brilliance is super charged by AI’s assistance. Every research university president should be reading this report and reflecting on what the future of higher education research should be.
https://t.co/y74Ai3mIhk

[Etched @Etched]

We’ve raised $300M in Series C funding at a $10.3B valuation from Sequoia, Andreessen Horowitz, Jane Street, Argo, and SK Hynix.

Our mission is to run the world's inference. This round accelerates production of our inference clusters.

We've opened an 80,000-sqft, 10-MW facility 15 minutes from our office to expedite production and prototyping.

[Nigel Xavier @nigel_xavier_]

@_chenglou when you dropped pretext i was inspired and built https://t.co/7BP8C7t02Q

would love to get your thoughts as it’s very similar in thesis here!

[Cloudflare @Cloudflare]

We're opening the waitlist for our Monetization Gateway, which will allow you to charge for any web page, dataset, API, or MCP tool behind Cloudflare. The charges will settle in stablecoins over the x402 open protocol. https://t.co/pvICtEIixj

[Nigel Xavier @nigel_xavier_]

https://t.co/3ZrUmMf4eX

[Nigel Xavier @nigel_xavier_]

from a very young age i knew language was a gift i was destined to give

i never thought that i would literally invent one

for the past 2 months i've been developing a programming language codesigned with my agent magnus

every language you know was made for/by humans

this one is for machines

[Nigel Xavier @nigel_xavier_]

the language is called SIGIL
from the latin word sigillum

meaning: a seal, a signature, a symbol

magnus handles the technical
i handle the philosophical

the organizing principle is authority as a capability

a framework for enforcing rules

thinking a lot about the concepts of secrets, security, substrates

[Alex Rives @alexrives]

Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.

We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.

ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.

A world model of protein biology emerges through language modeling.

We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.

The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.

This understanding emerges without prior knowledge, just from language modeling of protein sequences.

Language models are becoming a powerful substrate to understand and program biology.

The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.

I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.

[Josef Chen @josefchen]

Launching our new paper on arXiv: we trained the largest multilingual food model ever built.

4.1M recipes. 7 languages. 1,790 ingredients. 300 dimensions.

All of human cooking compressed into 2 megabytes.

[Nigel Xavier @nigel_xavier_]

the quality of your fitness function determines the ceiling of your evolution

[Nigel Xavier @nigel_xavier_]

Launching on Product Hunt May 6. If you have ever lost a week translating a design into code — or watched an AI generate something that looks nothing like your brand — this is for you.

[Nigel Xavier @nigel_xavier_]

You describe what your UI should feel like. ViewSpec turns that into a real, working interface — across any platform.

No Figma export. No design-to-code handoff. Just intent → UI.

https://t.co/7BP8C7t02Q

[Nigel Xavier @nigel_xavier_]

Open source SDK. Hosted API. Ship today, self-host tomorrow. Python: pip install viewspec. API: https://t.co/3j8M4KXmcA

[Nigel Xavier @nigel_xavier_]

Memory in production agent systems is built as a database. Vectors, graphs, key-value stores with clever retrieval.

The assumption: memory is a collection of objects, indexed and returned on query.

That assumption is wrong. Memory is a field, not a database.

https://t.co/Y3gg5NlTcq

[Nigel Xavier @nigel_xavier_]

@Rosebud_AI would love to check it out 🙏🏽

[Akshay Krishnaswamy @hyperindexed]

Alan Kay, pioneer of object-oriented programming and the graphical user interface, talking about agents and tools in 1990.