Last chapter of my PhD dissertation is finally out. Here, we investigated the role of inflammasomes and pyroptosis in Salmonella systemic infection induced coagulopathy. Many thanks to my advisors and all the helping hands to finish this project. Cheers!!
https://t.co/Cbp3UKfzhQ
Check out the latest from @BalaTejashiva, Nagakannan Pandian and team with @ThiruKanneganti@StJudeResearch, culminating a two decades-long search for NLRP12's trigger and downstream pathway!
Out today @CellCellPress. Congrats to the team! 👏
Thread 👇
https://t.co/63yFZrdOnf
A cell death mystery is solved.
Steinberg, Goldenberg and Trude Flo discovered that glycine protects dying cells from lysis at the level of NINJ1 oligomerization.
Kudos to all authors on this great work.
@LabSteinberg @GoldenbergLab @trudeflo
https://t.co/Ct996n6eu0
So cool! @WuLabHarvard @harvardmed solves @Nature the structure of the active #NLRP3#inflammasome showing that the LRR domain & NEK7 don’t participate in disk interfaces, suggesting the role of NEK7 is to break the inactive cage! https://t.co/dYRkKeeaSd
Now online @biorxivpreprint. The impact of Gasdermins on oral Salmonella infection. The fruits of a collaborative project led by former PhD student Stefan Fattinger and with contributions from colleagues at Shao lab, @broz_lab, @SellinLab and Hardt lab.
https://t.co/vnzReNYwYE
Our latest work led by @DanPBall shows that oxidized, but not reduced, TRX1 binds to and represses the NLRP1 inflammasome, revealing that the innate immune system senses reductive stress.
https://t.co/JtOTZzW23n
Over at @eLife, we’re eliminating accept/reject decisions and relinquishing the traditional journal role of gatekeeper.
This new model is our move towards a fairer system that helps researchers get recognition for what, not where they publish. Read more: https://t.co/XIzOyb7W1l
“You and I are living in a time when some miracle drugs no longer perform miracles and families are being ripped apart by a microscopic enemy.” Learn more about how you can fight the growing threat of #AntimicrobialResistance https://t.co/2kGcVAn1Mv #AntibioticResistance
I am glad to share that I completed my PhD defense last week. I would like to take this moment to thank my excellent mentors, lab mates, friends, family and all the well wishers who supported me throughout these years to achieve this step.#phd#bacteria#inflammasome#pyroptosis
A thread about using color as a design tool in science presentations. Color is a great tool to separate different categories of information, to highlight information, or to establish an emotional tone. 🧵1/20
Proud of @rajukarki16, @FrankSangjoon and the team for work @SciImmunology describing how ZBP1 induced by IFN therapy or naturally high levels of IFN drives negative outcomes during #coronavirus infection through cell death. Great job! @StJudeResearch https://t.co/F6iBOZ5o7I
Excited to have this paper out! Our new work in collab w/ Priya’s lab @KailasanVanaja shows a key role for CD14 in noncanonical inflammasome sensing of LPS in vivo. Congrats to Swathy Vasudevan @SwathyVasudevn, who led the work, Ashley & Puja @dolly_puja https://t.co/tSGTJBWb4e
We are happy to announce that our new toolbox for optogenetic activation of #apoptosis, #necroptosis and #pyroptosis is now online at #JCellBiol. How does it work and can you use it for your own research? Read our tweetorial! (1/9)
https://t.co/WpNo2PSV88
@NatImmunol is on 🔥these days about #inflammasome! Julie Blender & co show that bacterial #RNA works as a #vitaPAMP that potentiates #noncanonical inflammasome activation by binding #NLRP3 and assembling a complex between pro-cascade-11 & NLRP3!!! https://t.co/gG2NlLjjXX
For anyone who's spent way too long creating posters in PPT at 4000% zoom🔎😭
BioRender Poster Builder is officially launched! Magically resize columns, customize colors, vector export, and more🙌🏽 It's free to use and currently in beta. Lmk your thoughts! https://t.co/YWhw1aFnQD
1/ Hi twitter academia. This is a 🧵on an experience I had at a conference recently. After my oral presentation, I was TOLD that it was not reasonable to pose and test a hypothesis in mice based on observations made in the clinic. I was TOLD this was the WRONG way to do it.