Joyful

All things nature !!

[Joyful @nollagd]

@PhilAndrewPhoto Pity he didn’t do the same with Sam Prendergast twelve months ago - we are still suffering from that one

[Aakash Gupta @aakashgupta]

This isn’t a random scientist who got lucky.

Mariano Barbacid discovered the first human oncogene in 1982. He isolated H-RAS from bladder cancer cells and proved a single point mutation could trigger cancer. That finding launched the entire field of molecular oncology.

KRAS mutations cause 90% of pancreatic cancers. For 43 years, oncologists called KRAS “undruggable” because the protein had no obvious binding pocket. Barbacid spent the last decade using genetically engineered mice to systematically test every node in the KRAS signaling pathway, looking for combinations that would work without killing the patient.

The triple therapy blocks KRAS three ways at once: the main growth signal, the escape routes through EGFR and HER2, and the stress-response backup through STAT3. Cut the engine, seal the exits, disable the emergency system. Tumors vanished in mice and didn’t return for 200+ days after treatment stopped.

Pancreatic cancer has a 13% five-year survival rate. 8% for the ductal adenocarcinoma type this therapy targets. Most patients live one year after diagnosis.

The catch: this is preclinical. Human trials are 3+ years away. One of the drugs, RMC-6236, might get approved this year, but the full triple combination has regulatory hurdles.

Still. The man who discovered human oncogenes in 1982 may have just figured out how to eliminate the cancer those genes cause. That’s a 43-year arc from first principles to potential cure. Science rarely works this clean.

[Keith Siau @drkeithsiau]

This is Mariano Barbacid, a Spanish cancer researcher who recently made the news after finding a cure for an aggressive form of pancreatic cancer in mice. His lab developed a new triple therapy regimen targeting the KRAS cancer pathway, implicated in 90% of pancreatic cancers. The combination of daraxonsib, a RAS(ON) inhibitor, afatinib (EGFR/HER2 inhibitor) and SD36 (a selective STAT3 PROTAC) led to complete elimination of tumour cells over a 200 day study period, bringing much needed hope to this often devastating condition.

[Robert Burke @robertburke84]

The standout for me from the Mercosur deal is that after years of green fanaticism which has included Irish politicians making the case for the need to cull our national herd for the climate, the EU agrees to a trade deal to import sub-standard beef thousands of miles. Laughable.

[Joyful @nollagd]

@GardaTraffic can you please inform drivers of D reg cars that the right lane on a motor way is an overtaking lane - Cahir to Cork motorway full of D reg cars who never use the left lane !

[Gearóid Murphy @gearoidmurphy_]

We are being absolutely milked

[Joyful @nollagd]

@CianTracey1 Viewing is suited to GAA which uses a much larger pitch but is not for rugby - felt too far from the action - atmosphere was very flat !

[Carlow Weather @CarlowWeather]

Only 20 days to go until the days start getting longer🙌

[Joyful @nollagd]

@Luke_Hillery94 Agreed - they did extremely well to get 4- one team always got a far more difficult task and then got eliminated

[Daniel Hussey @DanielHussey2]

Make absolutely no mistake, that was a seismic win in Irish Rugby yesterday.

Munster went to Croke Park as 15 point underdogs and absolutely battered Leinster.

Meanwhile, Andy Farrell has 21 Leinster players in his Irish squad for November.

[Aine Hyland @ainehyland]

A great article. The last national convention on education in 1993 recognised that “teachers have made an enormous contribution to Irish society” and added that “the quality, morale and status of the teaching profession are of central importance to a first-class education system”

[Joyful @nollagd]

@shane_florish @TheAngryBarten3 @CrokePark Cork airport has a DRS machine snd a second one where you can donate the DRS to charity !

[Joyful @nollagd]

@SimonPGruber @mrcolmcrowley 166 days back is actually next Tuesday Aug 26- any day earlier is going to be taken as a day off at some stage during the year - max of 3 allowed

[Joyful @nollagd]

@SeanKellyMEP @mrcolmcrowley Secondary schools must go in next Tuesday to make up the required 166 days - any day before that is discretionary & a day will be taken off instead during the year !

[Joyful @nollagd]

@anndaly1 @IrishTimesEdu_ And yet the TUI recommended members to vote yes to accommodations offered - which are not going to solve anything - TUI are not hit for purpose - backtracking at its finest !

[Joyful @nollagd]

@frank_oconnor Large Dunnes store on the Main Street in Clonmel also left vacant for years - they refuse to rent or sell it apparently !

[Alex @AO1865]

First Hurling experience and this is what I’ve gathered.

It’s a game played by men built like rugby players, trying to score field goals like American football but also goals like football using hands like handball but also bats called Hurley’s similar to Lacrosse while implementing a no travelling rule like basketball whilst sprinkling a little bit of MMA violence in there with it.

It’s absolutely incredible, what a sport.

[Daniel Hussey @DanielHussey2]

Absolutely sensational stuff from Ben Healy to win 6th stage of the Tour De France ☘️

[Conor McKenna @conormckenna98]

Between Senior, U-20 and Minor, Tipperary have won 8 All-Ireland’s in 10 seasons.

More than any other county in Ireland in that timeframe.

Excellent underage players, brilliant senior management and big support following team.

Hurling in the county is in a fantastic place.

[Tipperary Supporters Club @TippSupporters]

Look what it means to the great man who’s done it all in the blue & gold!