Novotny Lab

Group of Membrane Receptors and Cell Signaling by Assoc. RNDr. Jiří Novotný, DSc. | @CharlesUniPRG | @science_charles | #novotnylab

[Novotny Lab @NovotnyLab]

Our research focuses on the molecular mechanisms of receptor signaling, particularly trimeric G protein-coupled receptors. We investigate their roles in various physiological contexts, using diverse methods to understand and potentially address related pathological conditions.

[Novotny Lab @NovotnyLab]

😱Check out this outstanding review article from our student @withdebanjan from @NovotnyLab: "Current perspectives on glioblastoma treatment synergies between therapies and delivery systems"
👉Read now: https://t.co/3WqoUsa9hv
#biomedical #CancerResearch #stemcellresearch

[Faculty of Science of Charles University @science_charles]

🎉 Faculty of Science researchers shine at the @NadaceNeuron Awards! 🏆
Congrats to Prof. Jan Černý for winning the Love for Science Award 🧪✨ and to Klára Hlouchová, Tomáš Pluskal, and Martina Benešová Schäfer for their achievements as promising scientists! 👏

[Novotny Lab @NovotnyLab]

Our talented dynamic student @MichalPaluba from
@NovotnyLab represented us at the 1st International Symposium on Horizontal Mitochondrial Transfer and Dynamics. #neuroscience #mitochondrialtransfer #hmtd24
➡️https://t.co/d2ylEoG5WO

[Novotny Lab @NovotnyLab]

Great success of Alp Yigit Özdemir from
@NovotnyLab with his article in Cellular & Molecular Biology Letters of @BioMedCentral with JIF: 9.2 ! Congratulations 👏👏👏 #Neuroscience @science_charles @CharlesUniPRG ➡️https://t.co/towTTZWdJH

[Novotny Lab @NovotnyLab]

👀Check out this outstanding review article in @EXCLIJournal: "Clusterin: a double-edged sword in cancer and neurological disorders," authored by Pinky Sultana of @NovotnyLab🧠.
➡️https://t.co/29I8QyR1OR
#clusterin #neuroscience #cancer #aging

[Janin Lautenschlaeger @Janin865]

Our first paper of the lab is out!!

While both, VAMP2 and alpha-synuclein have been extensively studied, we reveal a novel, unexpected role for their interaction.

#Parkinsons #Neuroscience @Cambridge_Uni

[Novotny Lab @NovotnyLab]

Our student @withdebanjan from @NovotnyLab represented us at the Federation of European Forum Societies (FENS) @FENSorg conference in Vienna with his project: "Exploring the Impact of Ibrutinib on Microglial Inflammation In Vitro". Great job👏👍
#FENS2024 #microglia #neuroscience

[Debanjan Das (Deb) @withdebanjan]

Had a great time at #FENS2024 ☀️ Vienna. It has been great to meet and talk with people within same field and also outside of my field. Lot of great poster, plenary sessions and symposium. Amazing experience in sunny Vienna. See you in Madrid 🇪🇸

[TheLuoLab @TheLuolab]

Finally out! Check out our new paper in Nature Communication 10.1038/s41467-024-49596-0. In this new study, we established that microglia make their own TGF-β1 ligand to maintain brain homeostasis and cognitive function via autocrine signaling mechanism at a single-cell level!

[Novotny Lab @NovotnyLab]

Great success of Pinky Sultana and her co-investigators @MichalPaluba and Alp Yigit Özdemir from @NovotnyLab for receving a GAUK grant for their project: "Investigation of oxidative stress- or amyloid-β-induced senescence in a 3D astrocyte model" 👏 #GAUK #neuroscience #astrocyte

[Imoto lab @YtImtDynmn]

Our new paper is out in @embojournal! We found an answer to a decade-old mystery: to sustain neurotransmission, how can we retrieve synaptic vesicles within 100 ms? The answer lies in a gene that we, bilaterian animals, have created, making synaptic vesicle endocytosis extremely fast.
https://t.co/kNePtznM5q

[Peng Jiang Lab @LabJiang]

Microglia transplantation therapy for treating neurodegenerative conditions
https://t.co/IU228Todpo
https://t.co/I4wYEw5dyr
@NeuroCellPress

[John Lukens @LukensJohnR]

-Lifelong absence of microglia causes neurodegenerative disease
-Transplantation of healthy microglia can rescue this neurodegenerative disease @NeuroCellPress https://t.co/4BiFpuBoqg

[Charles University @CharlesUniPRG]

🙌 Exciting opportunity for academics! The @4EUplusAlliance has launched the second round of the SEED4EU+ initiative.

🤝 With a particular emphasis on research activities, this program offers up to €50,000 in funding for innovative projects that enhance cooperation among the 4EU+ member universities. Project teams are encouraged to submit proposals by 30 September 2024. Join the information session on 21 June 2024 to learn more.

📌 Don't miss this chance to contribute to our mission of building One Comprehensive Research-Intensive European University! Read more here: https://t.co/fZNfEuTJsn

[Charles University @CharlesUniPRG]

🌍 Calling all prospective international students! 🌍
Are you considering Charles University for your higher education journey? We're excited to invite you to our digital advisory office! 🎓✈️

📅 Mark your calendars for our monthly Virtual Office Hours, where you can:

🤝 Connect with our friendly advisors
📚 Get personalised guidance on programmes, admissions, and student life
💡 Meet our student ambassadors
🗓️ Next Virtual Office Hours: June 19
🕒 Time: 15:00-16:30 (CET/GMT+1 – Prague local time)
📍 Where: Zoom https://t.co/NexkymDjTs

Don't miss out on this unique opportunity to explore your options and make an informed decision about your academic future. Whether you're curious about undergraduate or doctoral programs, we're here to assist you in every step of the way! 📚🌟

To learn more, visit our website. We can't wait to meet you and help you embark on your educational journey with Charles University! 🎉🌏

[Novotny Lab @NovotnyLab]

Role of TRH receptor activation in gene transcription, identifying key phosphosignaling pathways in GH1 cells, highlighting β-arrestin2's crucial role in TRH-R signal transduction by @ZDrastichova from @NovotnyLab.
➡️https://t.co/dUlV6fiZqy
#neuroscience #TRHreceptor #taltirelin

[Novotny Lab @NovotnyLab]

Congratulations to @hronova20441 for defending her master thesis: "Investigation of changes in epigenetic modofications in rat brain induced by morphine treatment" and for admission to doctoral studies in @NovotnyLab. Good luck with your future academic journey, Mgr. Anna. 👏👏👏

[Novotny Lab @NovotnyLab]

Congratulations to @EliskaPritulova for receiving GAUK grant with her project "Study of epigenetic regulation in the rat brain affected by chronic methadone administration and withdrawal" and also to her co-investigators @DanielaNov75805, @hronova20441 from @NovotnyLab. 👍 #GAUK

[Novotny Lab @NovotnyLab]

Great achievement of @withdebanjan from @NovotnyLab in GAUK with his project: "BTK inhibitor ibrutinib in the treatment of neuroinflammation and neurodegeneration".
Congratulations! 👏👏👏
#neuroscience #microglia #ibrutinib #btkinhibitor #glia

[Debanjan Das (Deb) @withdebanjan]

Exciting news! My PhD project has been chosen for a additional funding by the #GAUK Charles University Grant Agency. 🚀 Fingers crossed for a successful outcome! and I'm thrilled as this marks my first grant application and its approval.📷 #grantapplication #grant @CharlesUniPRG

[Novotny Lab @NovotnyLab]

Our talented student @withdebanjan from @NovotnyLab and @TheParcPrague represented us at the conference - Květinův Den held in Prague, Czech Republic. This motivational event, aimed at young pharmacologists and toxicologists, offered a fantastic platform for exchanging knowledge.

[Novotny Lab @NovotnyLab]

Amyloid β, linked to Alzheimer's disease, is influenced by cholesterol levels, which affect its production and the activity of related proteins. By Vladimir Rudajev from @NovotnyLab | #amyloidbeta #alzheimer #neuroscience | @science_charles @UniKarlova
https://t.co/qE9kCL0Xdh