Peng Jiang Lab

We use brain organoid and chimeric-brain platforms to uncover disease mechanisms and engineer human microglia for brain repair.

[Peng Jiang Lab @LabJiang]

Thrilled to share our review just published in @NeuroCellPress!
Big shoutout to Ava, Mengmeng , and our entire team!
https://t.co/DUBauRbexY

[Peng Jiang Lab @LabJiang]

Human brain cellular xenografts in neuroimmunology and beyond: Immunity https://t.co/GciXtBlDKM

[John Lukens @LukensJohnR]

A cross-species AAV platform for precise microglial interrogation: @NeuroCellPress https://t.co/5jQJcQ187O

[Peng Jiang Lab @LabJiang]

@ChenShuibing @WCMSurgery @UCLAHealth @dgsomucla Congratulations!

[Peng Jiang Lab @LabJiang]

@tischfield Same here...Human stem cell models are moving forward so fast. FOMO, but also excited to see all the amazing progress!

[Peng Jiang Lab @LabJiang]

When organoids meet chimeric brains! @Nature
https://t.co/5VYbAvCI3M

[Gan Lab @LiGanLab]

🎉New in Neuron! We identified that microglia-derived soluble DLK1 links aging to hypomyelination. In mouse and human iPSC models, telomere shortening drives microglial senescence, ↑sDLK1, and impaired oligodendrocyte maturation and neuronal activity. https://t.co/iNR0jS1xJa

[Gan Lab @LiGanLab]

From @Nature : The aging human brain is more dynamic than we thought. Somatic mutations revealed marrow-derived cells in every human brain studied, sometimes forming a large share of microglia, Clonal hematopoiesis was also linked to a lower risk of AD. https://t.co/mzah3qDhq8

[IdoAmitLab @IdoAmitLab]

Beautiful study lead by Julia, Howard, Siddhartha and co. follows the ontogeny of microglia in human aging
https://t.co/cSNI2NnEMN

[Peng Jiang Lab @LabJiang]

It also makes me wonder—what if this powerful strategy could be extended to engineer AAVs that specifically target human microglia?

[Peng Jiang Lab @LabJiang]

A truly groundbreaking study showcasing the transformative potential of human glial chimeric brain models for in vivo AAV evolution. Combining human glia-selective capsids with glymphatic delivery represents a landmark advance toward precise CNS gene therapy!

[Nature Biotechnology @NatureBiotech]

Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery https://t.co/A3NU2j28qd

[Peng Jiang Lab @LabJiang]

Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (https://t.co/IhI5j3nPgq)

The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.

[Peng Jiang Lab @LabJiang]

@KaurTejbeer Thank you, Tejbeer!

[Peng Jiang Lab @LabJiang]

Can grafted microglia be harnessed for neuronal replacement?

Motivated by their unique properties for cell-based therapies, we explored the direct conversion of human microglia into neurons. Excited to share our new study on bioRxiv.

[Peng Jiang Lab @LabJiang]

Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies: Neuron https://t.co/HSWmtJ3bVu

[Peng Jiang Lab @LabJiang]

All models have limitations. Animal models are indispensable for neuroscience research. Meanwhile, chimeric brain models provide opportunities to study human neural cells with advanced maturation and functional integration in an in vivo brain environment

https://t.co/vlZGIOLv32

[Peng Jiang Lab @LabJiang]

Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived ne... https://t.co/f5gu5aLisr

[Peng Jiang Lab @LabJiang]

In this study, we developed a series of new chimeric brain models by combining different transgenic mouse lines with co-transplantation of human microglia and neural cells, enabling in vivo studies of human neuro–glia and glia–glia interactions.

[Peng Jiang Lab @LabJiang]

Thrilled to share our new study published in @CellReports! 🎉

Led by @jin_mengmeng, @ZiyuanMa5, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and glial biology.

https://t.co/HLnVKSeOky

[Peng Jiang Lab @LabJiang]

Thank you for highlighting our work!

[Gan Lab @LiGanLab]

New study from Jiang group gives clues to Down syndrome patients' resilience to AD: DS-linked myeloid mutation CSF2RB A455D protects engrafted human microglia against tau by suppressing IFN signaling, boosting phagocytosis, & reducing microglial senescence https://t.co/YV22v9xott