Peng Jiang Lab

Engineering human microglia to model and repair the diseased brain
#iPSC #organoids #chimericbrains #Downsyndrome #Autism #Alzheimer's

[Peng Jiang Lab @LabJiang]

@KaurTejbeer Thank you, Tejbeer!

[Peng Jiang Lab @LabJiang]

Can grafted microglia be harnessed for neuronal replacement?

Motivated by their unique properties for cell-based therapies, we explored the direct conversion of human microglia into neurons. Excited to share our new study on bioRxiv.

[Peng Jiang Lab @LabJiang]

Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies: Neuron https://t.co/HSWmtJ3bVu

[Peng Jiang Lab @LabJiang]

All models have limitations. Animal models are indispensable for neuroscience research. Meanwhile, chimeric brain models provide opportunities to study human neural cells with advanced maturation and functional integration in an in vivo brain environment

https://t.co/vlZGIOLv32

[Peng Jiang Lab @LabJiang]

Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived ne... https://t.co/f5gu5aLisr

[Peng Jiang Lab @LabJiang]

In this study, we developed a series of new chimeric brain models by combining different transgenic mouse lines with co-transplantation of human microglia and neural cells, enabling in vivo studies of human neuro–glia and glia–glia interactions.

[Peng Jiang Lab @LabJiang]

Thrilled to share our new study published in @CellReports! 🎉

Led by @jin_mengmeng, @ZiyuanMa5, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and glial biology.

https://t.co/HLnVKSeOky

[Peng Jiang Lab @LabJiang]

Thank you for highlighting our work!

[Gan Lab @LiGanLab]

New study from Jiang group gives clues to Down syndrome patients' resilience to AD: DS-linked myeloid mutation CSF2RB A455D protects engrafted human microglia against tau by suppressing IFN signaling, boosting phagocytosis, & reducing microglial senescence https://t.co/YV22v9xott

[Peng Jiang Lab @LabJiang]

@LingyongLiLab Thank you, Lingyong!

[Peng Jiang Lab @LabJiang]

An idea we started in 2019 is now published in @NatureNeuro! Excited to share our new study: https://t.co/nSzotEAbHM

Congrats to Mengmeng Jin @jin_mengmeng and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!

[Peng Jiang Lab @LabJiang]

@LongJun_Wu Thank you so much, Longjun!

[Peng Jiang Lab @LabJiang]

@HarryFu80763542 Thank you very much, Harry!

[John Lukens @LukensJohnR]

A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease @NatureNeuro
https://t.co/cYeXsT2VLJ

[Peng Jiang Lab @LabJiang]

Explore our new study here 👇, and Happy Thanksgiving to all!

Author’s link: https://t.co/nSzotEAbHM

Rutgers Today article @RutgersU_News @RutgersSAS @RutgersU:
https://t.co/aXBvFerhlt

[John Lukens @LukensJohnR]

Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo https://t.co/23Q0ooXDsf @alzdemjournals

[Mariko Bennett MD PhD (she/her) @nachoriko]

Returned to this platform to amplify this beautiful work! Well done Sonia and all!

A major step forward and key experimental insights for how we advance this for many diseases.

[Jean Paul Chadarevian @JPChadarevian]

We are pleased to share our newest publication from the @BlurtonJonesLab, "CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies" https://t.co/j3X4rLBhGD

[Wu Lab at UTHealth @LongJun_Wu]

We are excited to announce the 3rd ASCN Symposium, Jan 28-30, 2026 in Houston! Featuring a keynote by Dr Hongkui Zeng @HongkuiZeng @AllenInstitute and 10 exciting sessions. Join us for cutting-edge talks, trainee award & networking!
Register at https://t.co/fhWEPAuQ5g

[Peng Jiang Lab @LabJiang]

This study was co-led by our talented undergraduate student, Kushal, whose curiosity and dedication inspired us all. Sadly, he passed away before its publication — this work stands as a tribute to his passion for science.

[Peng Jiang Lab @LabJiang]

Excited to share our new @STARProtocols paper!

We present step-by-step methods for purifying primitive neural progenitors by fractional passaging to generate astroglia-enriched cerebral organoids

Read here 👉: https://t.co/8XyTTZJOpZ