Nonia Pariente

@npariente.bsky.social @[email protected] Ed-in-Chief @plosbiology. Virologist. Feminist. Spaniard in the UK. Views my own.

[Nonia Pariente @npariente]

An exciting new beginning today as I join @PLOSBiology as Editor in Chief!

As the flagship PLOS journal in the life sciences, we aim to be a selective, fair, open access venue to ALL fields, to help advance discovery, depressurize the publication process & drive #openscience

[Eric Topol @EricTopol]

How to get bacteria to move from the gut into the brain?
—eat a high-fat diet
—vagus nerve is the conduit
—in the mouse model
https://t.co/BI6HIbVgPl

[Nonia Pariente @npariente]

@gonzamoratorio Vamos Gonza ánimo y adelante!

[Nonia Pariente @npariente]

@gonzamoratorio Gonza cuánto lo siento! Fuerza y suerte en la lucha amigo. Te mando un abrazo fuerte desde acá

[Andrea Gamarnik @GamarnikLab]

Cuantas vidas salvan las vacunas?
Se estima que salvan 6 vidas por minuto en los últimos 50 años !! 👇

[Nonia Pariente @npariente]

Vacciness have saved > 6 lives/min in the last 50 years, yet their importance & safety is often questioned

“We should not allow misinformation, disinformation, ignorance and defunding to hinder vaccine development, deployment & use”

My latest editorial

https://t.co/qIWEVrqFf6

[Nonia Pariente @npariente]

Vacciness have saved > 6 lives/min in the last 50 years, yet their importance & safety is often questioned

“We should not allow misinformation, disinformation, ignorance and defunding to hinder vaccine development, deployment & use”

My latest editorial

https://t.co/qIWEVrqFf6

[Prof Peter Hotez MD PhD DSc(hon) @PeterHotez]

My new article in @PLOSBiology out today. If you are a new- early- mid-career scientist or physician-scientist: Your future is not bleak, you are more powerful than you even realize. But it's different, the old way of NIH-K-R01-R01-P30 may shift, but there are new opportunities especially in biohubs. Here's the link to my paper https://t.co/XluVex3pn2

[Prof Peter Hotez MD PhD DSc(hon) @PeterHotez]

NEW: My latest article out this afternoon in ⁦@PLOSBiology⁩ https://t.co/6GvcEpJEUH

[César de la Fuente @delafuentelab]

Antibiotic discovery is notoriously hard and slow. What if we could change that by optimizing antibiotics on the computer?

Introducing APEXgo, our latest AI model, which integrates a transformer-based variational autoencoder with Bayesian optimization to design novel antibiotics.

Unlike traditional AI approaches, which rely on fixed databases of known molecules, APEXgo explores uncharted sequence space, proposing entirely novel peptides that have not been seen before.

We put APEXgo to the test with a bold challenge: could it design optimized compounds with antibiotic activity using templates from extinct organisms like woolly mammoths and giant sloths? 🐘🦣

The results? 🤯

· 100 peptides were synthesized and characterized for antimicrobial activity, mechanism of action, secondary structure, and cytotoxicity.
· APEXgo achieved an 85% experimental hit rate.
· 72% success in improving activity against dangerous Gram-negative pathogens —a major challenge.
· The antibiotics designed by APEXgo were effective in mouse models, even outperforming polymyxin B (a last-resort antibiotic).

This work represents the first ground-truth experimental validation of generative Bayesian optimization in any setting, and we are excited that its debut application is in antibiotic discovery.

With APEXgo, we have entered an era where AI accelerates antibiotic discovery and explores molecular diversity at digital speed. #AI #Antibiotics

Huge congratulations to my amazing Team and collaborators on this achievement: @mdt_torres, Yimeng Zeng, Fangping Wan, Natalie Maus, and Jake Gardner @Penn @PennMedicine @PennEngineers

Link to the paper: https://t.co/tvFbquK7IE

[PLOS Biology @PLOSBiology]

PLOS is no longer posting on this platform. Please follow us on Bluesky (https://t.co/PJKDMPXGoL) and continue to engage with us and our content.

[Nonia Pariente @npariente]

Such a cool anti-phage defense system
🧪

[Nicholas M. I. Taylor Lab @NMITaylorLab]

Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni https://t.co/AFPSKH14Za

[Tulio de Oliveira @Tuliodna]

First detailed modelling publication on Dengue virus importation risks in Africa, this seminal paper shows that African countries are being more exposed to outbreaks and epidemics. A thread 🧵https://t.co/mt8kGmNIlX

[EMBL Events @EMBLEvents]

Are you looking forward to 2025 as much as we are? 👀

We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look!

➡️ https://t.co/QMAxOlmGbR

#EMBLEvents #molecularbiology #lifesciencetraining

[Human Genome Org @humangenomeorg]

Meet our plenary speakers!
We are pleased to announce the distinguished plenary speakers for HGM2025. Come and listen to valuable perspectives shared by distinguished experts and leaders!
See you all at HGM2025!

Register Now: https://t.co/HJwd5PRruK

[Human Genome Org @humangenomeorg]

The updated programme is available on the website:
https://t.co/wZlENV8auy
Don’t forget to register. See you in Durban!

Register Now: https://t.co/HJwd5PRruK
Submit Abstract: https://t.co/Pl2eHZ56Zr
Apply for Travel Grant: https://t.co/5AlAOnreQo

[Human Genome Org @humangenomeorg]

Meet our speakers!
We are pleased to announce the distinguished speakers for HGM2025.
See you all at HGM2025!
Register Now: https://t.co/HJwd5PQTFc
Submit Abstract: https://t.co/Pl2eHZ4z9T
Apply for Travel Grant: https://t.co/5AlAOnqH0Q

[Human Genome Org @humangenomeorg]

Submit your abstract for the presentation during HGM2025. Abstract submissions will only be accepted electronically through the abstract submission form that will be open until December 14th, 2025.
Register Now: https://t.co/HJwd5PQTFc
Submit Abstract: https://t.co/Pl2eHZ4z9T

[Nonia Pariente @npariente]

@ThurstonLab Congratulations!

[Human Genome Org @humangenomeorg]

Early-bird registration is extended until Saturday, December 14th, 2024!
Register now for Human Genome Meeting 2025, which will be held in Durban, South Africa on March 11-14, 2025. Don't miss this final opportunity to secure your spot!
Register: https://t.co/HJwd5PQTFc

[Yan Zhang @cryoTM]

Excited to join the Editorial Board of @PLOSBiology, the #PLOS flagship journal in the Life Sciences, that's blazing a trail in support of selective, equitable #OpenScience and reaching global audiences to help advance science faster.