Nelson V. Simwela, PhD

Postdoc at Cornell University
#Tuberculosis #HIV #Host_Pathogen_Interactions #Cell_Biology #Systems_Biology #Malawi

[Ingentium @Ingentium_Inc]

Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis. https://t.co/t90bRm04YV

[Centre For Parasitology @WCIPGLASGOW]

At the airport to welcome our next cohort of Beit/@UofGlasgow funded #Malawian students today. They will all take up Masters courses 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🇲🇼 @UofGVC @ScotlandMalawi @ScotGovID

[bioRxiv Microbiology @biorxiv_micrbio]

Incorporation of macrophage immune stresses into an assay for drug tolerance in intracellular Mycobacterium tuberculosis https://t.co/1t6Widr7sw #biorxiv_micrbio

[Barbara Stokes @bhstokes]

Congratulations to the newly minted Dr. Divala!! Couldn’t be prouder!!

[Nature Rev Immunol @NatRevImmunol]

How macrophage heterogeneity affects tuberculosis disease and therapy https://t.co/ETJH3FROLx

[SpaceX @SpaceX]

Wishing you a warm holiday season and a lit New Year

[Nelson V. Simwela, PhD @nsimwela]

Our second story out as a reviewed preprint @eLife. @SassettiLab
https://t.co/IoDmb6OIPa

[Davide Pisu @mtbmeds]

Cool story from @nsimwela He developed a CRISPR-based genetic screen in Hoxb8 macrophages and found inhibition of the GID/CTLH E3 complex inhibits growth of Mtb and Salmonella. The GID complex is currently a drug target in cancer, so there is hope for potential new anti-TB drugs.

[Nelson V. Simwela, PhD @nsimwela]

Article highlight: https://t.co/J0IaZshuwv

[Nelson V. Simwela, PhD @nsimwela]

First story from my postdoc in the Russell lab @cornellvet out today in @NatureComms. We performed a genome wide CRISPR knockout screen in primary macrophages and identified the 12 member GID/CTLH proteosomal complex as a negative regulator of intracellular bacterial growth.

[Nelson V. Simwela, PhD @nsimwela]

A great collaboration with the @SassettiLab at @UMassChan. Article: https://t.co/SJyGYPp6jW

[Elon Musk @elonmusk]

Good morning

[Davide Pisu @mtbmeds]

Happy to share our new work “The frequency of CD38+ alveolar macrophages correlates with early control of M.Tuberculosis in the murine lung” is finally out in @NatureComms . @Mattila_TB_Lab @LuanaJohnston13 with support from @CornellCFI @CornellGenomics https://t.co/Z5b9fRZS3F

[Waggoner Lab @LabWaggoner]

CD38+ monocyte-derived & tissue-resident alveolar macrophages are significant controllers of Mycobacterium tuberculosis growth in lung, with intranasal BCG immunization increasing the numbers of CD38+ macrophages @mtbmeds
https://t.co/sHnakdiH5g

[microscopic images. @microscopicture]

electron microscope image of a blue bottle fly larva

[Saikat Boliar @Saikat_Boliar]

I am looking for motived postdocs (2 positions) to join our research team. We study HIV persistence in AMs during therapy and also investigate the role of lncRNAs in HIV latency. Interested candidates should email me directly. Any retweet is highly appreciated.

[Franziska Hentzschel @FHentzschel]

I am super happy about the opportunity to continue unraveling the mysteries of #malaria #parasite development in the mosquito, now funded by an #ERCStG! This is gonna be fun!

https://t.co/1DHpxEShVc

[bioRxiv Microbiology @biorxiv_micrbio]

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis https://t.co/ka2HxZpqpQ #biorxiv_micrbio

[BBC News Africa @BBCAfrica]

BREAKING: An aircraft carrying Malawi's Vice President Saulos Chilima and nine others has gone missing, a statement from the president's office said.

The Malawi Defense Force aircraft "went off the radar" after leaving the capital, Lilongwe, on Monday. https://t.co/mY1cxWuLYR

[UofG Sii @UofGSii]

🆕 | @UofGSii's Professor @AndrewPWaters was announced as the recipient of the prestigious @EMBL lifetime achievement award at the recent #BioMalPar Conference in @EMBLHeidelberg, Germany.

Congratulations, Professor Waters!

🔗 Full story: https://t.co/6DZjmjQcbV