Ruth V. Nichols & Brendan L. O'Connell

Husband & wife PhD duo working on single-cell epigenomics at Oregon Health & Science University with @acadey80. Ruth maintains the account.

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

It's been a while, but we published sciMETv3 in @CellGenomics in the beginning of this year!! https://t.co/sIcoeGBwP5

[bioRxiv Genetics @biorxiv_genetic]

Atlas-scale Single-cell DNA Methylation Profiling with sciMETv3 https://t.co/nsRTSIgYoW #biorxiv_genetic

[bioRxiv Neuroscience @biorxiv_neursci]

Single-cell DNA methylation analysis tool Amethyst reveals distinct noncanonical methylation patterns in human glial cells https://t.co/8tyZSKDo2F #biorxiv_neursci

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

Our daughter's latest artwork: "Science Kitty"

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

Very excited that @acadey80 presented on sciMETv3 at #AGBT24 ! I am very proud to say that I (Ruth) am the lead on this :)

[Edoardo Giacopuzzi @Supergecko]

sciMET v3, an interesting method for large-scale single-cell methylation study presented by Andrew Adey. Using combinatorial indexing and methyl region capture they can now generate meth profile for 10^5 cells. #AGBT24

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

This new kit is based off our protocol!

[Scale Biosciences @scalebio]

Our new Single Cell Methylation Kit is now available for pre-order.
Get a revolutionary view into cellular heterogeneity.

Pre-order now: https://t.co/Akdn44bJ5v

#singlecell #methylation #scalebio

[Andrew Adey @acadey80]

New preprint! sciMET-cap, where we use hybrid capture to reduce the sequencing burden of scMethylation and show ~6,000 cell preps are possible using a benchtop sequencer! Led by S. Acharya and @oconnellphds with @DrTedPBraun & @L_Rylaarsdam. https://t.co/UARwDtdUDr

[Andrew Adey @acadey80]

Summary of our latest two papers on GenomeWeb! Thanks for the coverage - we are excited about both of these techniques regarding how they can improve the scale of single-cell epigenomic studies; both led by @oconnellphds! @OHSUSOM #singlecell #epigenetics

[Andrew Adey @acadey80]

Excited to have our work using the @TakaraBioUSA iCell8 instrument with single-cell combinatorial indexing to achieve high-throughput scATAC out in early access in @genomeresearch led by @oconnellphds! #singlecell @OHSUSOM @OHSUNews @OHSUBrain (1/4)
https://t.co/MvhUeEfyJl

[Nature Communications @NatureComms]

A high-throughput method for generating single-cell DNA methylomes with high coverage @acadey80 @oconnellphds

https://t.co/xAvlY2uWdu

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

Super excited to have our paper out today! Went from the first experiment to an accepted paper in 1 year!

[Andrew Adey @acadey80]

1/6 Very excited to announce sciMETv2 for high-throughput robust single-cell DNA methylation analysis led by @oconnellphds out in @NatureComms!

#SingleCell @OHSUBrain @OHSUKnight @OHSUNews @OHSUSOM #epigenetics

https://t.co/xIDl2VXxkR

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

@love_dalen The sequencing adapters on the molecule ends are like the covers of the books. Lots of books (reads) in the library. 🤷

[Oregon Zoo @OregonZoo]

Ice machine's set to ottermatic

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

@marissacoconut It was written in the 60s before Sci-Fi was a major genre.. so the fact it has any 'sci-fi names' is saying something

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

@OregonZoo has the best content on Twitter by far

[Oregon Zoo @OregonZoo]

Happy Halloween

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

@marissacoconut Rancher

[Ruth V. Nichols & Brendan L. O'Connell @oconnellphds]

New paper from our lab is out today! Brendan is a co-author. He worked on the s3-GCC portion

[Andrew Adey @acadey80]

Our recent work on developing "s3" as a means of achieving increased unique read counts per cell for transposase based assays came out today! Led by Ryan Mulqueen along with an excellent team of collaborators.
https://t.co/e4QE8uadxt

[Oregon Zoo @OregonZoo]

Cub in a tub

[Oregon Zoo @OregonZoo]

Happy fifth birthday to Maple! Her team threw a party with branches, otters and Filbert, who took a cookie to go.

[Rahul Satija @satijalab]

Interested in single-cell genomics but need help keeping up with a rapidly changing field? Check out our free #singlecellgenomicsday workshop, starting in a few minutes! Full agenda and livestream at https://t.co/KJpeGwWLIr, or follow along below:
https://t.co/nA1uC9gne5