Hob Gadling

Mysterious CAN guy.

[Hob Gadling @OliveChirper]

Hmmm... are you actually still admitting new contestants, @j_n_justice @xprize ?

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

David Sinclair plans to test whole-body rejuvenation drugs in the XPrize competition

The next step in the youth quest is a technology called chemical reprogramming.

@davidasinclair @techreview

https://t.co/hDRczBzi8F

[Hob Gadling @OliveChirper]

@k_storoschuk Excellent: looking forward to both!

[Hob Gadling @OliveChirper]

@k_storoschuk When are your papers on your study of Zone 2 training (the new study, not the now-famous review) and on lactate as a measure of mitochondrial health coming out?

[Hob Gadling @OliveChirper]

@EricTopol This article borders on libel. Attia has never suggested "that some shadowy cabal of elites is hiding" the keys to good health, and does not "make money from lawsuits against vaccine companies." In fact, he has dedicated multiple podcasts to refuting antivaxx nonsense.

[Hob Gadling @OliveChirper]

@ElieJarrougeMD @Metabolic1992 Sure there is: we have a whole armamentarium for this.

[Hob Gadling @OliveChirper]

@Optispan_Inc All added sugars are included in the Nutrition Facts label.

[Hob Gadling @OliveChirper]

@sandypaul1413 @deniseminger Fullly hydarogenated oil is essentially saturated fat.

[Hob Gadling @OliveChirper]

@sandypaul1413 @deniseminger I'm surprised to hear that. Partially hydrogenated vegetable oils are essentially banned in the US and Canada, and the EU has a limit of 2 grams trans fat per 100 grams of fat which is effectively a ban.

[Hob Gadling @OliveChirper]

@sandypaul1413 @deniseminger Hydrogenated oils are illegal in most industrialized countries today.

[Hob Gadling @OliveChirper]

@deniseminger The objection that the intervention lowered total cholesterol and therefore can't have had much trans fat seems cogent. Yes, trans fats could lower HDL-C even as they raise LDL-C, but is it really plausible that it could do it so much as to lead to a net reduction in TC?

[Hob Gadling @OliveChirper]

@ValerieAnne1970 1. This study in American centenarians found they have LOW total cholesterol https://t.co/JrbT488nBd 2. LDL, not total cholesterol, is the analyte of interest for ASCVD risk.

[Hob Gadling @OliveChirper]

@arunkumar3112 This study is specifically of LDL in elderly people. As is well-known, LDL levels (& blood pressure, & BMI) decline in the last 10 y of life, making low levels falsely appear good. The proper study design is to look at long-term outcomes in people with low LDL from midlife on.

[Hob Gadling @OliveChirper]

@GarySmithInKY @arunkumar3112 "Never can get it that low:" have you tried all the lipid-lowering therapies? A statin, and even more so a PCSK9 inhibitor, should easily reach that target.

[Hob Gadling @OliveChirper]

2 NBC journalists take @ElysiumHQ's epigenetic age estimator,take their full suite of supplements for 7 months.On re-test, one's estimated age gets worse(better-than-chronological estimate at baseline gets CLOSER to chron age), other one's stays the same https://t.co/NAnKmNV6Uc

[Hob Gadling @OliveChirper]

@LookingAtYouM8 @ElieJarrougeMD I am (again) believing large, randomized, placebo-controlled trials with multiple agents that lower LDL via different mechanisms and all lower MACE, plus Mendelian randomization. Epi is a cherry on top, and run by academics, not pharma.

[Hob Gadling @OliveChirper]

@bigfatsurprise So no article like this, for instance. https://t.co/VTlEsRHpSF

[Hob Gadling @OliveChirper]

@LookingAtYouM8 @ElieJarrougeMD Not "without question:" there is extensive scientific documentation, including large RCTs, and work by independent scientists.

[Hob Gadling @OliveChirper]

@LookingAtYouM8 @ElieJarrougeMD Big Pharma has produced four classes of drugs that lower LDL via different mechanisms, and they all lower MACE in large RCTs. Plus Mendelian randomization. This debate is over.

[Hob Gadling @OliveChirper]

@LookingAtYouM8 @ElieJarrougeMD LDL is well-established as the causal root driver of ASCVD.

[Hob Gadling @OliveChirper]

@AndrewKaufmanMD You made this up. This question has been scientifically tested. The worst you can say is that it doesn't *increase* survivorship https://t.co/HZpFc6w6hr