Oleksii Zdorevskyi

[Vivek Sharma @vivekvivsharma]

Check our new article in @ChemicalScience

https://t.co/8U7GZipCra

Catalytic relevance of quinol anion in biological energy conversion by respiratory complex I

Computer simulations by @olZdorevskyi #JohannesLaukkanen

We study #ubiquinone reduction and dynamics in complex I

[Vivek Sharma @vivekvivsharma]

Check QM/MM gradient analysis and visualization tool by #JohannesLaukkanen

https://t.co/Zum9tDC1HA

Abstract: Visualize force vectors on QM region atoms of a QM/MM MD trajectory produced by NAMD/ORCA software. Analyze data such as force magnitudes and angles between vectors.

[Vivek Sharma @vivekvivsharma]

@helsinkiuni @KumpulaPhysics @KumpulaScience @BIOTECH_UH. Thanks to @CSCfi @SuomenAkatemia @SigridJuselius #ErkkoFoundation #FinnishSocietySciLett

[Vivek Sharma @vivekvivsharma]

In the current work, we show histidine dynamics is central for function of antiporter (complex I). Histidine switch function is perturbed by point mutations

[Vivek Sharma @vivekvivsharma]

The work highlights the power of combining chemical biology approaches with computer simulations in complex I research. MD simulations by @tina_pecorilla.

[kj @megane_de_noppo]

Structural Elucidation of the Mechanism for Inhibitor Resistance in the Na+-Translocating NADH-Ubiquinone Oxidoreductase from Vibrio cholerae | Biochemistry https://t.co/iWXz49FPxu

[Masatoshi Murai/村井正俊 @MstMurai]

I'm excited to share our latest work!
Congratulations, Moe!
Structural Elucidation of the Mechanism for Inhibitor Resistance in the Na+-Translocating NADH-Ubiquinone Oxidoreductase from Vibrio cholerae | Biochemistry https://t.co/CeOJ46Bgbk

[Vivek Sharma @vivekvivsharma]

Reminder

Deadline tomorrow for postdoctoral position in computational biophysics, University of Helsinki, Finland.

[Vivek Sharma @vivekvivsharma]

Postdoctoral researcher position available in our group at the University of Helsinki, Finland

Interested candidates, see the description on the link below and apply

https://t.co/dEoM09pkIv

[Vivek Sharma @vivekvivsharma]

Check our new work on a histidine molecular switch in mitochondrial complex I and Mrp cation/proton antiporter.

[Faculty of Science, University of Helsinki @KumpulaScience]

Humans are capable of adapting to a wide range of temperatures. Researchers from @harvardmed and @helsinkiuni explored how #cold #adaptation is triggered in brown adipose tissue by increasing mitochondrial energy production.
@vivekvivsharma
https://t.co/n8sS7POzJt

[Oleksii Zdorevskyi @olZdorevskyi]

I was privileged to apply the QM/MM simulation technique to study electron transfer processes in cold-adapted respiratory complex I. Thanks to @vivekvivsharma and @Amina93364815. Work done in collaboration with @PpuigserverB and @platorremuro.

[Vivek Sharma @vivekvivsharma]

Happy to share our joint work with @platorremuro @puigserver_lab on #mitochondrial CI:CIII2 #supercomplex in @CellCellPress.
Structural basis of respiratory complex adaptation to cold temperatures: Cell https://t.co/rUKvth4uXo. Simulations by @Amina93364815 @olZdorevskyi

[Vivek Sharma @vivekvivsharma]

Check our new article in @BBAjournals. Joint work with @JonathanLasham @Amina93364815 #GeorgiosKolypetris @JanetVonck #VolkerZickermann

[Vivek Sharma @vivekvivsharma]

Check our new preprint on the "Catalytic relevance of quinol anion in biological energy conversion by respiratory complex I" @biorxivpreprint
https://t.co/SPBPpURbQL . Simulations by @olZdorevskyi #JohannesLaukkanen. A thread