Nimesh Chahare

Doing epithelial mechanics! Convenor @EpiMechFC
Postdoc @NerurkarLab @ColumbiaBME
Past: PhD @XavierTrepat lab @IBECBarcelona; ME @IiscMechanical

[Nimesh Chahare @onenimesa]

How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx

[Nimesh Chahare @onenimesa]

How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx

[Nimesh Chahare @onenimesa]

Thanks for following along! 🙏

This work wouldn't exist without the wonderful Nerurkar Lab
& the humble chicken embryo system.

Special thanks to Nandan for the mentorship & support. Code is public: https://t.co/zyImpxpGZs
Have a curved tubular tissue? Spatchcock it.

[Nimesh Chahare @onenimesa]

How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx

[Nimesh Chahare @onenimesa]

What drives the thickening?
We mapped cell division across the whole neural tube

The DV mitotic gradient is conserved
This is far more complex than a passive shell

Floor/roof plate signaling likely encodes the pre-pattern, while mechanics drives the global shape change

[Nimesh Chahare @onenimesa]

@IkbalChoudhur20 @pauguillamat Thank you!

[Nimesh Chahare @onenimesa]

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: https://t.co/b7PVuHZVCO
🧵with pressure control, multiscale buckling, patterned wrinkling

[Xavier Trepat @XavierTrepat]

Our latest work on shape-programmable tissues is out in @ScienceMagazine.
https://t.co/6Nbo3srcvE
Collab with Marino Arroyo’s lab, led by @pauguillamat at @IBECBarcelona

[FocalPlane @focalplane_jcs]

Meet the Epithelial Mechanics Fan Club @EpiMechFC
@onenimesa and @JuliaEckert10 introduce us to the Epithelial Mechanics Club.
Learn how you can get involved with this community: https://t.co/Wom47o7MAE

[Tom Golde @tom_golde]

Check out the preprint of my main work in the lab of @XavierTrepat @IBECBarcelona. Many thanks to all the people involved!

[epithelial mechanics fan club @EpiMechFC]

🎉 Happy International #EpithelialMechanics Day! 🎉

[epithelial mechanics fan club @EpiMechFC]

Over the past 2 years, we have enjoyed reading the wonderful threads of our delegates around the world. Thank you!

What have we missed? What is your favourite topic? Your recent paper?

Click the link below to sign up and share your passion with us 👇
https://t.co/kFZGWVd6Kd

[Nimesh Chahare @onenimesa]

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: https://t.co/b7PVuHZVCO
🧵with pressure control, multiscale buckling, patterned wrinkling

[Nimesh Chahare @onenimesa]

@DhirajIndana Thanks a lot😊. Dhiraj!

[Xavier Trepat @XavierTrepat]

A thread of our new preprint 🧵👇 🤩

[Nimesh Chahare @onenimesa]

Thank you Xavi!

Click on this to see epithelial pressure control, multiscale buckling, controlled wrinkling

https://t.co/ggRd8mvTEA

[Xavier Trepat @XavierTrepat]

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa🙌. Theory by Marino Arroyo and team.
https://t.co/Gtmqggt4ou

[Özge Özgüç @oozguc]

to buckle or not to buckle that is the question🤔
So great to see this work out!! Big congrats to @onenimesa and the team!!👏

[Xavier Trepat @XavierTrepat]

🚨 Second preprint of the week!

We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.

We harness these mechanical instabilities for synthetic morphogenesis.

Led by @onenimesa🙌. Theory by Marino Arroyo and team.
https://t.co/Gtmqggt4ou

[Nimesh Chahare @onenimesa]

I want to acknowledge that it truly takes a village to conduct science and produce preprints.
A huge thank you to the my labs!
specifically the Moli team:
@tom_golde Thomas Wilson, @oozguc
Marino Arroyo & @XavierTrepat

[Nimesh Chahare @onenimesa]

Finally, we could use control of shape to rationally direct buckling into predictable wrinkle patterns.
9/10