How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx
How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx
Thanks for following along! 🙏
This work wouldn't exist without the wonderful Nerurkar Lab
& the humble chicken embryo system.
Special thanks to Nandan for the mentorship & support. Code is public: https://t.co/zyImpxpGZs
Have a curved tubular tissue? Spatchcock it.
How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @ColumbiaBME :
https://t.co/r55hwGqAOx
What drives the thickening?
We mapped cell division across the whole neural tube
The DV mitotic gradient is conserved
This is far more complex than a passive shell
Floor/roof plate signaling likely encodes the pre-pattern, while mechanics drives the global shape change
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: https://t.co/b7PVuHZVCO
🧵with pressure control, multiscale buckling, patterned wrinkling
Meet the Epithelial Mechanics Fan Club @EpiMechFC@onenimesa and @JuliaEckert10 introduce us to the Epithelial Mechanics Club.
Learn how you can get involved with this community: https://t.co/Wom47o7MAE
Over the past 2 years, we have enjoyed reading the wonderful threads of our delegates around the world. Thank you!
What have we missed? What is your favourite topic? Your recent paper?
Click the link below to sign up and share your passion with us 👇
https://t.co/kFZGWVd6Kd
Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?
New #EpithelialMechanics pre-print: https://t.co/b7PVuHZVCO
🧵with pressure control, multiscale buckling, patterned wrinkling
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
https://t.co/Gtmqggt4ou
🚨 Second preprint of the week!
We uncover the multiscale dynamics of active viscoelastic buckling in epithelia.
We harness these mechanical instabilities for synthetic morphogenesis.
Led by @onenimesa🙌. Theory by Marino Arroyo and team.
https://t.co/Gtmqggt4ou
I want to acknowledge that it truly takes a village to conduct science and produce preprints.
A huge thank you to the my labs!
specifically the Moli team:
@tom_golde Thomas Wilson, @oozguc
Marino Arroyo & @XavierTrepat