OpenWorm

OpenWorm is an open science project dedicated to creating the first digital organism, a C. elegans nematode. Get involved at

[OpenWorm @OpenWorm]

@lu_sichu @WileyGlobal of which?

[OpenWorm @OpenWorm]

In 1986, John White published "The Mind of a Worm," the first complete wiring diagram of any animal's brain. 7,000+ synapses, mapped by hand.

This year, he was awarded the @WileyGlobal Prize in Biomedical Sciences.

He's donating his share to @OpenWorm.

[OpenWorm @OpenWorm]

This is the largest single donation in OpenWorm's history. We won't waste it.

Full announcement + 2026 plans: https://t.co/91HOHHCz0d

[OpenWorm @OpenWorm]

We're organizing 2026 around:
29 Design Documents specifying how to model C. elegans, under scientific review
A contributor progression model (Observer to Maintainer)
AI-assisted contribution pathways

The science is human-led. The scaling is AI-augmented.

[OpenWorm @OpenWorm]

Bravo @eboyden3 and @koerding !

https://t.co/G7Jsgf0Ura

[OpenWorm @OpenWorm]

Interested in doing post-doctoral work with OpenWorm? Check out this opportunity in the UK!

https://t.co/YNFpvuA2oh

[OpenWorm @OpenWorm]

Now streaming: OpenWorm interview on the @DataSkeptic podcast https://t.co/8iK8DTNU8Z

[OpenWorm @OpenWorm]

Bravo to all the authors! (4/4)

[OpenWorm @OpenWorm]

A major obstacle to modeling the nervous system of the worm has been the unknown weights of the connections. Which are excitatory or inhibitory and how strong? Well, the lab of @AndrewLeifer has put out a Neural Signal propagation atlas to address this critical gap (1/4)

[OpenWorm @OpenWorm]

Their preprint is online here: https://t.co/kYD3gBMAxO and you can explore the data set via an online browser here: https://t.co/WQk5RumcBX and a basic simulator based on these data here: https://t.co/IDBMoLQVRk (3/4)

[Max Tegmark @tegmark]

Fun to interactively play on the @OpenWorm site with our best mapped nervous system yet, and to think about building a virtual organism: https://t.co/o5BwGEMch7

[OpenWorm @OpenWorm]

Promising resource from the Flavell lab with freely moving whole-brain calcium imaging datasets: https://t.co/2NSBwNxk1C

[Piali Sengupta @SenguptaLab]

Omg @YeminiLab. The White Knight of neuron identification. As designated by Keynote Speaker Oliver Hobert. And well deserved moniker too. Go NeuroPAL! #Worm23

[Daniel Colón Ramos @dacolon]

How friendly is worm community? We converged on finding w Cohen and Emmons lab. Papers came out together (below). Started Glasgow #Worm23 w stimulating discussions over haggis pizza w Netta Cohen to discuss collaborations
1) https://t.co/ROg9X9sK00
2) https://t.co/Ipdwyhp9S0

[Sandhya Koushika @WormlockHolmes]

All winning entries of the #wormart at #Worm23 @GeneticsGSA. Wait until the end for a QR code for all entries. @foodskop started Art show in 1997. Do tag the winners/participants & RT. @chud8 @VarshaS53228024 @wormsense

[MIT Picower Institute @MIT_Picower]

#Serotonin is a common but complex target of psychiatric drugs. A new study by the @MIT lab of Steven Flavell provides a deep but also brain-wide look at its role in producing behavior in C. elegans. https://t.co/AFSYACrsKM @ScienceMIT @mitbrainandcog #neuroscience