Our new preprint is a significant milestone for us
We built "HealthFormer" by training on our deeply phenotyped cohort from the Human Phenotype Project data. Healthformer is a multimodal generative transformer model that tokenizes each participant's physiological trajectory across 667 modalities (biomarkers, body comp, sleep, CGM, microbiome, wearables, meds) and is trained with a single objective: predict the next measurement
Forecasting, risk stratification, and intervention-conditioned simulation all arise as queries from one shared representation
Key findings:
→ Matches direction of effect in 41/41 published RCTs; 30/41 within the reported 95% CI
→ Reconstructs biomarkers at r > 0.9; forecasts 2 yrs ahead
→ Validation on external data from UK Biobank, NHANES, PNP3, Framingham
→ Outperforms Framingham CVD & PREVENT-ASCVD on 27/30 endpoints
→ Predicts individual 6-mo responses in a held-out RCT
Paper: https://t.co/Y82xI9U5hn
Great work by Guy Lutsker, Gal Sapir, Jordi Merino, Smadar Shilo, Anastasia Godneva, Eli Meirom, Shie Mannor, Hagai Rossman, Gal Chechik
Can what you eat today measurably change how you sleep tonight?
In 4,793 person-nights from the Human Phenotype Project (HPP), we linked real-time dietary logs with high-resolution, multi-stage wearable sleep recordings and applied a target-trial emulation framework to estimate day-level effects on next-night sleep physiology.
Key findings:
• Higher fiber density → ↑ deep & REM sleep, ↓ light sleep, ↓ nocturnal heart rate
• Greater plant diversity & whole-plant intake → improved nocturnal autonomic down-regulation
• Meal timing → modulates sleep duration and cardiovascular tone
• Macronutrient energy distribution (carbs/fat/protein %) → no robust short-term effects
Small, realistic day-to-day dietary differences appear to produce measurable physiological changes by the next night.
Project led by the bright @ShkolnikMa15652 from @segal_eran Lab,
In collaboration with @galsapir_ , @smadarshilo , @YeelaTalmor@WeizmannScience , @Pheno_AI , @mbzuai , Tel Aviv University, Schneider Children’s Medical Center of Israel, and Rabin Medical Center
@VladimirBeliak אתה פרלמנטר מצוין ועושה עבודה חשובה בועדת הכספים. יש עתיד תמחק בבחירות הקרובות (בצדק רב) וחבל שאתה לא תהיה בכנסת הבאה. אנחנו צריכים מקצוענים כמוך - עבור למפלגה שנלחמת עבור המצביאים שלה ותמשיך לתרום