Pancession

Pandemic + Recession = #Pancession. The 2020 double whammy.

[Pancession @pancession]

The COVID-19 recession is a major global recession which arose as an economic consequence of the ongoing #COVID19 pandemic.

@IMFNews says this will be most severe global economic downturn since Great Depression, far worse than Great Recession of 2008-09

https://t.co/FAfjyeevN8

[Pancession @pancession]

Study: Inhibition of CXCL10 and IFN-γ ameliorates myocarditis in preclinical models of SARS-CoV-2 mRNA vaccination https://t.co/4gN5AO7B7r ($)

Story: Scientists Explain How mRNA COVID Vaccines May Rarely Cause Myocarditis https://t.co/rq81dsrJci

#Cardiac #Spheroids #genistein

[Pancession @pancession]

COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults in France—Semenzato et al. https://t.co/budAolTrAm

Results: no increased risk of 4-year all-cause mortality in ppl 18-59 vaccinated against COVID-19, further supporting the safety of mRNA vaccines
#COVID_19

[Carolyn Barber, MD @cbarbermd]

🚨 NEW: One of the largest COVID-19 vaccine studies ever (28 MILLION people in France) just dropped.

Results?
• 74% lower risk of death from severe COVID-19
• 25% lower risk of all-cause mortality
• No increase in 4-year mortality
• Vaccinated people had lower risk of death from any cause.
In short: mRNA vaccines weren’t just safe — they were protective across the board. 🔥📉

[Dr. Tom Frieden @DrTomFrieden]

This week, CDC’s vaccine advisory committee, which Secretary Kennedy has stacked with anti-vaccine voices, will meet. They’re slated to discuss vaccines to combat hepatitis B, measles, mumps, rubella, varicella (MMRV), and Covid – and we’re likely to see dangerous claims designed to scare and deceive people.

One of those claims is that vaccines cause unexplained childhood deaths. They do not.

[Prof Jeffrey S Morris @jsm2334]

What about this repeated claim that “vaccine safety has never been studied” because a fully unvaccinated vs childhood vaccine trial studying long term outcomes has not been done?

This is not an honest claim.

A randomized “long-term vaccinated vs. unvaccinated” trial is simply not feasible. Anyone suggesting otherwise should spell out exactly how they would design such a study.

In real practice, randomized trials are used, but for existing vaccines they compare new products against the standard of care—not against placebo…because medical ethics require it.

Even setting ethics aside, a placebo-controlled childhood vaccine trial testing all vaccines and looking at long term outcomes would be impossible: it would require tens or hundreds of thousands of children to be followed for many years, with those randomized to placebo kept entirely unvaccinated throughout childhood, and those randomized to vaccine compelled to receive it on schedule.

What parent who believes in vaccines would ever consent to the chance of their child remaining completely unvaccinated? And what parent opposed to vaccines would agree to risk their child being randomized to receive them? In reality, neither group would participate. And even if they did, how would one decide which vaccines and which schedule were “the trial”? The idea collapses under its own weight.

When people wave around the absence of such a study as proof that “safety has not been established,” they are not acting in good faith. It is a rhetorical trick, not a serious scientific proposal.

Of course, the fact that randomized trials cannot detect rare long-term effects does not mean those effects are unstudied. By necessity, they are investigated in large real-world observational studies. The U.S. has built a multi-layered vaccine safety monitoring system for exactly this purpose:
•VAERS for hypothesis generation,
•VSD and other active systems to test and validate signals,
•CISA to investigate individual cases of suspected harm, and
•v-safe for real-time monitoring of short-term effects not captured elsewhere.

No system is perfect, but taken together they are reasonably robust.

They can certainly be utilized better, results more transparently publicized, and the system improved in various ways.

The constructive path forward is to improve these systems—not ignore or dismiss them.

Those who seriously care about detecting and reducing vaccine harms should engage with and strengthen these monitoring tools.

Those who instead repeat the line that “safety has never been studied” are not trying to advance science. They are advancing an agenda: to sow doubt, obstruct vaccination, and enrich trial lawyers.

[Awesomics @Awesomics]

“The process of recommending vaccines in the US has undergone a seismic disruption. The government has abruptly changed vaccine policy through social media postings & publications in news media… we consider paths forward for U.S. vaccine policy.”
https://t.co/CC07ShVgFO

#ACIP

[Helen Branswell 🇨🇦 @HelenBranswell]

The dismantling of the science-driven #ACIP continues, with members of professional groups (pediatricians, family docs, obgyns, etc) that have liaison status on the panel that shapes #CDC's vaccination policy told they are biased, can't serve on ACIP work groups. https://t.co/1ExoVwjQ0r

[Jake Scott, MD @jakescottMD]

Public trust in vaccines is built on facts, honest & transparent communication, and steady expertise. Replacing ACIP’s scientists with outspoken skeptics does the opposite.

I explain why in my new @statnews op-ed: https://t.co/0t8SNMKQpR

[Prof Jeffrey S Morris @jsm2334]

The report HHS sent to congress to justify the changes in vaccine recommendations for healthy non-elderly people and pregnant women has all kinds of misrepresentations and errors, as outlined by this report, and clearly does not accurately reflect the state of the scientific literature.

For myo/pericarditis, it cites a paper that is currently under investigation with a "notice of concern" and misrepresents VAERs data to imply a 2500% increase in myocarditis. There are much better papers that document the myo/pericarditis risk and accurately describe the magnitude of the increased risk.

He cherry picks a paper (that is not peer reviewed yet) to say that only vaccinated had myocarditis, when clearly there is vast literature showing myocarditis also occurs in unvaccinated individuals, especially after covid infections. Social media posts have tried to make these claims based on this paper, and the authors of the paper have argued that is not an accurate interpretation of their results of their study.

The scientific literature has documented evidence of significantly increased myo/pericarditis risk after mRNA vaccination, especially in young men and teen boys, and especially after doses 1-2 when the dosages were higher. But his justification misrepresents and exaggerates.

For pregnancy risks, his evidence is even worse.

With many other papers showing no increase in pregnancy loss after vaccination, he cherry picks one paper claiming it shows increase of pregnancy loss, when their analysis after confounder adjustment showed no evidence of any increase. And as I mentioned he ignores all of the other papers showing no evidence of an increase.

He cites a paper for a claim that vaccines increase placental blood clotting, but that paper does not even study placental blood clotting, or even study pregnant patients.

Not sure who wrote the report, but it is not a quality scientific report providing evidence for the proposed changes.

https://t.co/oghWDYz6yD

[Jake Scott, MD @jakescottMD]

It’s understandable to have questions about aluminum in vaccines. Here are the key facts:
🧵

[Pandemic A. Index @pan_accindex]

Babies who aren't protected against SARS-CoV-2 develop neurodevelopmental impairments. https://t.co/68KrkdJOpa

[Billy Hanlon @bhanlon15]

CBS News: 'Researcher says Long COVID causing "great deal of suffering"

'The CDC estimates nearly 20 million Americans are struggling with the effects of Long COVID -- the persistence of ongoing health problems long after the infection has passed'

https://t.co/oxf7U8giOZ

[Pancession @pancession]

@tonybrasunas @DrNeilStone What’s the source of that data graph?🤔

Measles cases in the US from @CDCgov — steep decline happened only AFTER 1963 when measles vax was licensed: https://t.co/RlndlozbXB

In prior decade, 3-4 million ppl in the US were infected yearly w 400-500 deaths: https://t.co/ntFsujCMzL

[Neil Stone @DrNeilStone]

"Vaccines aren't actually responsible for the reduction in infectious diseases" say Joe Rogan's guests

And he believes them

Meanwhile in the real world 👇👇

[Eric Topol @EricTopol]

On the cognitive costs of #LongCovid
https://t.co/KQSHXSbsYv
@ahandvanish @zalaly @MichaelPelusoMD @jannamoen by @richardsima

[charlos @loscharlos]

“That amounts to 45 different studies that were designed to uncover the biological mechanisms that may drive.. #LongCovid… these studies were nearly complete. In most cases, researchers had already finished data collection.”

[Vipin M. Vashishtha @vipintukur]

Two-thirds of people with #LongCovid have persistent, objective symptoms—including reduced physical exercise capacity and reduced cognitive test performances—for a year or more, with no major changes in symptom clusters during the second year of their illness. 1/

[MRC Centre for Global Infectious Disease Analysis @MRC_Outbreak]

Are we getting healthier? Sir John Curtice and Rachel Wolf discuss the state of Britain's health and the long term trends impacting the nation with prof Neil Ferguson 👇
https://t.co/xhJBFt6kx3

[Neil Stone @DrNeilStone]

HPV vaccine reduces risk of cervical cancer

This is clear. The data is unequivocal

If you dont believe this, then you are either absolutely hopeless at interpreting data or are wilfully lying about it in order to push some other agenda

RFK Jr doesnt believe HPV vaccines work

[Jon Douglas @atranscendedman]

Scientists found that key glycans on the SARS-CoV-2 spike protein are vital for infection and cell fusion.

Removing them stopped the virus, pointing to a potential target for pan-coronavirus treatments.

https://t.co/cWphWF68GC

[Michael Osterholm PhD, MPH @mtosterholm]

This is a brand new type of H5N1 virus activity.  My description of over 40 million migratory waterfowl and their poop blowing in the wind with H5N1 virus attached isn't appealing but it is exactly what is happening and we're going to see more human cases related to that.