@audispain Ademas las clavijas del coche de carga del teléfono ambas han dejado de funcionar y son 800 euros el cambio
Un desastre.
Sin duda de coche y de atención
Para venderlo y no saber nada más de audi
A busy #ESMO25 warrants an episode of the @IASLC podcast, Lung Cancer Considered, to help highlight some of the new data! Watch next week for this episode with Drs. @LeXiuning@DrRiyazShah@pedrofsrocha!
🙌🏽 Back to back sessions at #ESMO25 by @pedrofsrocha 💥
📌 DeLLphi-304 Tarlatamab 2L for #SCLC
ORR 33-37% irrespective of CFI
⬇️ Risk of death HR 0.60
☣️ Lower tox!
📌 IDeate-Lung01: intracranial activity of ifinatamab deruxtecan (IDXd)
✔️ ORR 46%
@OncoAlert@myESMO@_SEOM
Congratulations to the winner of the @IASLC 2025 Daniel C. Ihde Lectureship Award for Medical Oncology at #WCLC25 - Dr. @HendriksLizza - who reminds us of the need to rethink trial eligibility to answer relevant questions and to make lung cancer research sustainable.
HARMONi: Ivonescimab+CT ⬆️ PFS vs CT in post-osi EGFRm NSCLC.Qx:
-How and when to place this strategy based new SoC 1st line?
-Control arm trial was CT not CT+Ami
-Data support Ivonescimab in EGFRm (table)
-What EGFRm obtain higher benefit of IVO? Predictive biomarkers
#WCLC2025
Chemotherapy duration shown here - and fairly high crossover rates are reassuring. More toxicity, yes, but no new signals seen here. Question remains - which regimen for which patient? But a very welcome advance and impressive presentation from @dplanchard at #WCLC25.
FLAURA2 trial: Osi + CT improves PFS & OS (⬇️ 23% risk death) vs Osi alone in mEGFR NSCLC. Qx:
-Intensification for all pts? Benefit in some subgroups only (Brain)
-Chemo or ami for intensification?toxicity QoL, relevant for decisions
-Cost
-Is Osi alone no more valid?
#WCLC2025
Sotorasib is a Pan-RASG12C-, with activity in NRASG12C+ cancers @CD_AACR:
- sotorasib 5x ⬆️potent against NRASG12C vs KRASG12C or HRASG12C (activity in all)
- pt w NRASG12C+ CRC had prolonged response to soto+panitumumab
@OncoAlert #LCSM https://t.co/bowOYELJVJ
Luckily 2021 = Relevant year 💥 for new treatment approvals in aNSCLC🫁 (some approved in early stage). For 2022 📕✏️: not need more “me too” drugs⛔️; need new agents at the time of PD based on resist mechanisms (not easy!!) & less inequities (fig. not perfect!) @OncoAlert#LUNG
Immunotherapy works in almost all thoracic malignancies including MPM 👏🏻👏🏻. Its role in thymic malignancies (rare and orphan) deserves further evaluation despite NIVOTHYM trial reported meaningful clinical data. Good for having clinical trials ongoing #ESMO21@OncoAlert