Remember leiomyosarcomas arising from vessels may be aggressive unlike leiomyosarcoma from arrector pili. This LMS arising from vein; note residual vascular wall at periphery. Residual vein top left corner on image 2 & 3. Ref: Italiano A, et al. PubMed PMID: 20167595. #dermpath
Myoepithelial carcinoma from upcoming @ARP_Press fascicle. Nodular pattern of pushing invasion, zonal nodules w hypercellular edge & hyalinized/ necrotic core. Squamous metaplasia and myxoid stroma. ~1/2 arise from PA, many with PLAG1 or HMGA2 fusions. Unpredictable behavior.
1/
Necrosis = cell death (unlike apoptosis, it does not occur naturally and is not programmed)
This short #Tweetorial shows you some of the histologic flavors of necrosis. The stain in each of these pics is hematoxylin-eosin (H&E)
#pathology#pulmpath#pathtweetorial
Usually located at the edge of the testis and displacing its parenchyma, metastatic tumors can mimic a primary testicular malignancy. This is an example of desmoplastic small round cell tumor (DSRCT). Confirmed EWSR1 FISH. @GUpath@urology
Fibroepithelioma of Pinkus, basal cell carcinoma fibroepithelioma type, Pinkus tumor, new WHO (4th edition) calls it fibroepithelial basal cell carcinoma. Whatever your preferred name, it's a pretty tumor. #pathology#dermpath
GAMNA-GANDY BODIES:
-named after Carlos Gamna (Italian) & Charles Gandy (French)
-were misidentified as fungal hyphae
-can be seen in spleen, cardiac myxomas & rarely lymph nodes, thyroid, CNS
#pathology#GUpath#Kidney
Smooth Muscle Hamartoma 👶👶🔬✏️
✔️Rare
✔️Congenital lesion
✔️flesh colored plaque
✔️Composed of randomly arranged bundles of mature smooth muscle in the dermis
✔️overlying epidermis may show hyperkeratosis, acanthosis and hyperpigmentation
#pathology#dermpath#PediPath