PbLab

Research group of Pablo Barrio.
Really focusing in C(sp3)-H activation, mechanistic studies and riched F(sp3) molecules.
Student run twitter.

[PbLab @PbLabUniOvi]

Together with the Sigman and Niemeyer teams, we developed interpretable statistical models to qualitatively predict the regio- and diastereoselectivity of a gold(I)-catalyzed C(sp³)–H functionalization.

Congratulations to all the authors!

🔗https://t.co/CS2NZMAsCJ

[Rubén Miguélez @MorenRmm]

🔗https://t.co/WYl3WDtvX0 (7/7)

#MachineLearning #GoldCatalysis #CHFunctionalization

[Rubén Miguélez @MorenRmm]

Since I first encountered organic chemistry, I have been fascinated by total synthesis and by the decisions behind every synthetic route.

Can we anticipate whether a retrosynthetic disconnection is promising before stepping into the lab? 🧵 (1/7)

[BuresGroup @BuresGroup]

Are you interested in doing a PhD in mechanistic studies of catalytic reactions? Think no more:
https://t.co/LwKVAp8zOw

[Rubén Miguélez @MorenRmm]

https://t.co/b5082fxGmu
@PbLabUniOvi

[Rubén Miguélez @MorenRmm]

Is cyclopropane really that innocent in the gold-catalyzed cycloisomerization of 1-bromoalkynes? 🧐 In our attempt to synthesize new bromocyclopentenes bearing a cyclopropane ring, we found that the reaction was strongly inhibited. Check it out ⬇️

[Félix Rodríguez @FelixRod_UniOvi]

Our newest @NatureComms study on vinyl cations is out! The journey led us to a surprising and compelling mechanistic story. Huge thanks to all coworkers and collaborators who made this possible.
https://t.co/ERdNsDS5K8

[Rubén Miguélez @MorenRmm]

🚨 Check out the latest chapter of Comprehensive Organic Synthesis (3rd ed.) — a deep dive into allyl borons! 🤠 #OrganicChemistry #Synthesis.
https://t.co/wDA9mcReab

[Pablo Barrio Fernández @PabloBarrioChem]

Honored to see two of our recent @JOC_OL publications among the most read this month!! Check them out in the following post(I also leave the link of our third OL this month, which will appear back-to-back with the second one). Thanks to the readers of @JOC_OL for the interest

[PbLab @PbLabUniOvi]

Special thanks to @MorenRmm and @OmarartoOAS for the outstanding synthetic work, to Prof. Haberhauer and his team for the calculations, to Isabel for her detailed NMR studies, and to @PabloBarrioChem for his guidance throughout the project. 🙌

[PbLab @PbLabUniOvi]

We are excited to share our two back-to-back papers in @JOC_OL! 🚀 We studied how conformations affect the cycloisomerization of 1-bromoalkynes, highlighting the key role of a methyl group on the cyclohexane ring. https://t.co/jcnPEO2DtO

[PbLab @PbLabUniOvi]

At PbLab we are moving toward more complex systems, studying new variables to unlock regioselective reactivity. Collaborations with leading groups will broaden the impact of our work. Stay tuned! 👀

[Omararto @OmarartoOAS]

🎉Our new scientific contribution is out now!!🎉Herein we present an overview of how the conformational effects affect the outcome of our gold(I)-catalyzed cycloisomerizarion of 1-Bromoalkynes. (1/3)
https://t.co/YHb0LkbxSX

[Omararto @OmarartoOAS]

Again, thanks to @PabloBarrioChem for the opportunity, to Dr. Merino for the meticulous NMR characterization, and the Haberhauer team for the calculations. Special thanks to @MorenRmm for his enormous contribution — check his profile for more details!!!✨(4/4)

[Omararto @OmarartoOAS]

✨I'm also very happy to announce that the second part of our study is out now in @JOC_OL!!✨ Herein we present an overview of how conformational effects influence the outcome of our gold(I)-catalyzed cycloisomerization of 1-Bromoalkynes. (1/4) https://t.co/PDvvldGUIf

[Omararto @OmarartoOAS]

By using terpenes as nature-given stereochemical probes, we can access highly complex substituted substrates. Moreover, conformational effects not only rule selectivity but also reactivity. A preliminary study of the 5-exo-dig cyclization is presented. (2/4)

[Omararto @OmarartoOAS]

This 5-exo-dig transformation shows some really interesting features which are currently being studied at @PbLabUniOvi. We are so excited to share our work with the community. Please, stay tuned to find out more about these powerful transformations!!!✨(3/4)

[Rubén Miguélez @MorenRmm]

Thanks to everyone who contributed to this project, especially @OmarartoOAS for the outstanding synthetic work (stay tuned for what’s next) and @PabloBarrioChem for guiding us along this path. Check out 🧐: https://t.co/Y9jOOTL8kd

[Rubén Miguélez @MorenRmm]

In terpene derivatives we discovered a new 5-exo-dig reactivity, unprecedented on electronically unactivated C–H bonds. The mechanism, under study by @OmarartoOAS, may involve an endo vinyl cation-type transition state, a species not previously observed.