Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem@InstitutImagine @UnivRennes1 https://t.co/CronXo3e4n
@CellPressNews@NeckerInem@casanova_lab@GorochovG@institutpasteur This silent autoimmune state, revealed upon viral infection, may affect ~0.4% (<70 yrs) to 4% (>70 yrs) of the population and represents a common and global determinant of severe viral disease.
Online now: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals https://t.co/NocEnW414t
Des scientifiques ont découvert comment l'infection par le variant #Omicron BA.1 remodèle la mémoire immunitaire chez des patients vaccinés, améliorant ainsi les capacités des cellules mémoires à reconnaître le #SARSCOV2 et à le neutraliser.⤵️
https://t.co/04TjzhIdIi
Une équipe de recherche a analysé la mémoire immunitaire après infection par le variant Omicron BA.1 chez des patients vaccinés avec trois doses du vaccin COVID-19 à ARN messager.
https://t.co/noERxvo6Bl
🔬Our new article is now online at @ImmunityCP ! We analyzed how memory B cell repertoire is remodeled by Omicron breakthrough infection💉🦠🧫! Great collaborative work! @NeckerInem@institutpasteur@APHP @IMRB_Mondor @PChappert @MahevasMatthieu https://t.co/BOKwWy44iS 👇🧵
Overall, our results imply that separate mechanisms such as early telomere elongation, affinity selection during the contraction phase and access to a specific niche contribute to ensuring the functional longevity of MBCs.
Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem@InstitutImagine @UnivRennes1 https://t.co/CronXo3e4n
Instead, these long-lived MBCs appeared enriched in a CD21hiCD20hi IgG+ splenic B cell subset displaying a marginal zone-like NOTCH/MYC-driven signature and harbored long-lasting elongated telomeres.
Diversity is the key! Our new pre-print shows that the diversity of their repertoire allows memory B cells to control SARS-CoV-2 variants. Thanks to all for this collaborative study! @NeckerInem@institutpasteur @IMRB_Mondor https://t.co/gzoJ2ADt72