Pascal Chappert

[Pascal Chappert @PChappert]

Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 https://t.co/CronXo3e4n

[Pascal Chappert @PChappert]

@CellPressNews @NeckerInem @casanova_lab @GorochovG @institutpasteur This silent autoimmune state, revealed upon viral infection, may affect ~0.4% (<70 yrs) to 4% (>70 yrs) of the population and represents a common and global determinant of severe viral disease.

[Pascal Chappert @PChappert]

🚨 Proud to share our new study in @CellPressNews: B cells producing auto-Abs that neutralize type I IFNs in severe viral infections. Work from AI2B_lab @NeckerInem, @casanova_lab, @GorochovG and Rey’s labs @institutpasteur. https://t.co/hrx6OdZqQH

[Pascal Chappert @PChappert]

@CellPressNews @NeckerInem @casanova_lab @GorochovG @institutpasteur Our data support a model where T-cell tolerance breakdown drives a germinal center B-cell response against type I IFNs, months to years before severe viral infection.

[Immunity @ImmunityCP]

Online now: SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals https://t.co/NocEnW414t

[Inserm @Inserm]

Des scientifiques ont découvert comment l'infection par le variant #Omicron BA.1 remodèle la mémoire immunitaire chez des patients vaccinés, améliorant ainsi les capacités des cellules mémoires à reconnaître le #SARSCOV2 et à le neutraliser.⤵️

https://t.co/04TjzhIdIi

[Assistance Publique – Hôpitaux de Paris (AP-HP) @APHP]

Une équipe de recherche a analysé la mémoire immunitaire après infection par le variant Omicron BA.1 chez des patients vaccinés avec trois doses du vaccin COVID-19 à ARN messager.
https://t.co/noERxvo6Bl

[Aurélien Sokal @AurelienSokal]

🔬Our new article is now online at @ImmunityCP ! We analyzed how memory B cell repertoire is remodeled by Omicron breakthrough infection💉🦠🧫! Great collaborative work! @NeckerInem @institutpasteur @APHP @IMRB_Mondor @PChappert @MahevasMatthieu https://t.co/BOKwWy44iS 👇🧵

[Pascal Chappert @PChappert]

Overall, our results imply that separate mechanisms such as early telomere elongation, affinity selection during the contraction phase and access to a specific niche contribute to ensuring the functional longevity of MBCs.

[Pascal Chappert @PChappert]

Proud to present our new story coming out in @ImmunityCP on decades old long-lived anti-smallpox/vaccinia memory B cells. Great collaborations and contributions from SFR Necker platforms!! @NeckerInem @InstitutImagine @UnivRennes1 https://t.co/CronXo3e4n

[Pascal Chappert @PChappert]

Instead, these long-lived MBCs appeared enriched in a CD21hiCD20hi IgG+ splenic B cell subset displaying a marginal zone-like NOTCH/MYC-driven signature and harbored long-lasting elongated telomeres.

[Aurélien Sokal @AurelienSokal]

Diversity is the key! Our new pre-print shows that the diversity of their repertoire allows memory B cells to control SARS-CoV-2 variants. Thanks to all for this collaborative study! @NeckerInem @institutpasteur @IMRB_Mondor https://t.co/gzoJ2ADt72