Latest paper from @TangyeMaLab describing regulatory role of STAT5 in restraining human B-cell and Tfh cell differentiation & function. Explains enhanced responses of memory vs naive B cells, and disease in STAT5 deficiency.
https://t.co/bD6eDhA97y
1/ In this first @SciImmunology paper (https://t.co/1uTHUO7w9c), we show that at least 1% of men younger than 60 years with life-threatening COVID-19 are sick because of X-linked recessive (XR) TLR7 deficiency.
In 2 papers in @SciImmunolog, we report that inherited TLR7 deficiency underlies life-threatening COVID-19 in >1% of men <60 yrs (https://t.co/1uTHUO7w9c), while auto-Abs neutralizing type I IFNs underlie > 20% of critical cases in patients >80 yrs (https://t.co/EMZrAkMNM1)
We have been silent for a while because our lab and the CHGE were entirely focused on finishing 'twin papers' in @ScienceMagazine about inborn errors of type I IFN or auto-antibodies to type I IFN in nearly 15% of patients with life-threatening #COVID19 😀 https://t.co/E85pF1Kg88
Pleased to share the logo and website (https://t.co/Jg9jfS9BbV) of our #COVIDHumanGeneticEffort to discover monogenic inborn errors of immunity to SARS-CoV2 in previously healthy patients < 50 years admitted to an ICU. Please RT.