Simon Pelham

[Simon Pelham @pelham_simon]

@stutangye Happy birthday Stu!!!

[TangyeLab @Tangye_Lab]

Latest paper from @TangyeMaLab describing regulatory role of STAT5 in restraining human B-cell and Tfh cell differentiation & function. Explains enhanced responses of memory vs naive B cells, and disease in STAT5 deficiency.
https://t.co/bD6eDhA97y

[Casanova Lab @casanova_lab]

1/ In this first @SciImmunology paper (https://t.co/1uTHUO7w9c), we show that at least 1% of men younger than 60 years with life-threatening COVID-19 are sick because of X-linked recessive (XR) TLR7 deficiency.

[Casanova Lab @casanova_lab]

In 2 papers in @SciImmunolog, we report that inherited TLR7 deficiency underlies life-threatening COVID-19 in >1% of men <60 yrs (https://t.co/1uTHUO7w9c), while auto-Abs neutralizing type I IFNs underlie > 20% of critical cases in patients >80 yrs (https://t.co/EMZrAkMNM1)

[The Onion @TheOnion]

Scientist Really Thought Job Would Be Less Grant Writing And More Glow-In-The-Dark Lizard Making https://t.co/WPKyvP5kXi

[Immunoglitch @immunoglitch]

Biallelic TRAF3IP2 variants causing chronic mucocutaneous candidiasis in a child harboring a STAT1 variant https://t.co/12FEfFNMrD @casanova_lab @anne_puel

[Casanova Lab @casanova_lab]

1/ Here is Masato Ogishi's report in @NatureMedicine of a child with autosomal recessive, complete PD-1 deficiency (https://t.co/yR6Nde2fPU).

[Simon Pelham @pelham_simon]

@chelseahoughton Can't wait to listen!

[Simon Pelham @pelham_simon]

@ElissaDeenick @ProfPCDoherty @GarvanInstitute @SimonJunankar That cake is brilliant!

[Casanova Lab @casanova_lab]

We have been silent for a while because our lab and the CHGE were entirely focused on finishing 'twin papers' in @ScienceMagazine about inborn errors of type I IFN or auto-antibodies to type I IFN in nearly 15% of patients with life-threatening #COVID19 😀 https://t.co/E85pF1Kg88

[Simon Pelham @pelham_simon]

@stutangye Congrats Stu! I'm looking forward to reading it!

[Simon Pelham @pelham_simon]

@VI4Research @RMBarricarte @VUMChealth @VUMC_Medicine @VUMCgenetics Congrats Ruben!

[Casanova Lab @casanova_lab]

Pleased to share the logo and website (https://t.co/Jg9jfS9BbV) of our #COVIDHumanGeneticEffort to discover monogenic inborn errors of immunity to SARS-CoV2 in previously healthy patients < 50 years admitted to an ICU. Please RT.

[Simon Pelham @pelham_simon]

@nhmrc @stutangye @GarvanInstitute @ProfPCDoherty @sahmriAU Congratulations @stutangye!

[Simon Pelham @pelham_simon]

@stutangye @casanova_lab @YelenaNemirovs1 @BoissonDupuis @Boisson_Bebo That's crazy Stu! I'm glad that the fires are mostly under control now!

[Simon Pelham @pelham_simon]

@Manu___Singh @CellCellPress Congrats Manu! Nice work!

[Simon Pelham @pelham_simon]

@RMBarricarte @VUMCgenetics @VI4Research @VUMC_VCI @VUMCResearch Congrats guys! Awesome news!

[Simon Pelham @pelham_simon]

@DPapandreaPhD Thanks Dominick!

[Simon Pelham @pelham_simon]

@bier_julia @genesearch Classic

[Simon Pelham @pelham_simon]

@YelenaNemirovs1 Thanks Yelena!