Pere Canals 🍐

Doctor in Medicine | Medical Image & AI at Stanford University | Biomedical & Physics Engineering

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with 𝘙𝘌𝘛 fusion–positive non–small-cell lung cancer, adjuvant selpercatinib led to longer event-free survival than placebo. Adverse events of grade 3 or higher included elevated liver-enzyme levels. Full phase 3 LIBRETTO-432 trial results: https://t.co/o3iLF3tu6p

@ASCO

[NEJM @NEJM]

For patients with acute ischemic stroke, endovascular thrombectomy has improved outcomes in large-vessel occlusions, but its benefit in medium-vessel occlusions remains contentious. Research findings from the ORIENTAL-MeVO trial are summarized in a new Quick Take video. https://t.co/llPDSrhiyI

[NEJM @NEJM]

Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage. Full ORIENTAL-MeVO trial results: https://t.co/FvyLPQz4CV

Editorial: Endovascular Therapy for Medium-Vessel Occlusion Stroke — Narrowing the Target Population https://t.co/hnLi0DvzuF

[Demis Hassabis @demishassabis]

Excited to launch Gemma 4: the best open models in the world for their respective sizes. Available in 4 sizes that can be fine-tuned for your specific task: 31B dense for great raw performance, 26B MoE for low latency, and effective 2B & 4B for edge device use - happy building!

[JNIS @JNIS_BMJ]

🧠⚡️ Systematic review of 532 LVO patients shows super large bore aspiration catheters achieve high access (92%) and strong reperfusion (81%) with low complications, but modest first-pass effect (~55%) and reliance on non-randomized data highlight the need for larger prospective trials. Read more here: https://t.co/b6gHNIY6qN
@MagJablonska @marcriboj

[AshuJadhav @AshuPJadhav]

XCath Makes Medical History With the World’s First Remote Robotic Intervention in a Stroke Patient - https://t.co/KvEXtzDbEK

[JNIS @JNIS_BMJ]

🧠🔬 Neuro-dedicated intravascular OCT is emerging as a promising tool for intracranial vascular imaging. By enabling microscopic, high-resolution visualization of vessel wall pathology and therapeutic devices, it may expand our understanding of cerebrovascular disease and improve neurointerventional diagnosis and treatment strategies. 📖 Read more (open access): https://t.co/uGur9YugEj
@Cure4Stroke @_AdnanSiddiqui @Fie0815 @vitorpereiraca

[Phylo @phylo_bio]

Introducing agentic trial emulation: Biomni scaled clinical trial emulation using 12M patients EHR data at Mount Sinai.

Researchers used Biomni to autonomously emulate multiple landmark anticoagulation RCTs end-to-end within their EHR—turning months of manual target trial analysis into scalable, agent-driven workflows that can extend across large numbers of trials and diseases.

Running many emulations in parallel enabled something new: learning a stable institutional transport signal that quantifies how published trial effects systematically translate in local care.

Read more: https://t.co/ENqACOvt4u

Exciting work with @BenGlicksberg @joshualampertmd Justin Kauffman et al

[Barack Obama @BarackObama]

Today, the Trump administration repealed the endangerment finding: the ruling that served as the basis for limits on tailpipe emissions and power plant rules. Without it, we’ll be less safe, less healthy and less able to fight climate change — all so the fossil fuel industry can make even more money.

[Boris Cherny @bcherny]

A huge part of this raise is Claude Code.

Weekly active users doubled since January. People who've never written a line of code are building with it. Humbled to work on this every day with our team.

[Julieta Rosales @J_Rosales_MD]

🔥🔥MeVO RCT summary ❌❌❌✅✅

#ISC2026
@SposatoL @WorldStrokeEd @SVINJournal @WorldStrokeEd @EdmontonStroke @StrokeAHA_ASA @ShadiYaghi2

[European Stroke Org @ESOstroke]

New at #ESOC2026:
Be part of the future of #stroke innovation. Pitch your breakthrough idea at the new Innovation Session bringing together academia, start-ups, industry&investors.

🗓️ Submit by 28 Feb: https://t.co/hIOG5aI1mJ
🎥 Carlos Molina explains why.

#VoiceOfStroke

[James Zou @james_y_zou]

Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep����

We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.

AI learns the language of sleep🧵

[JNIS @JNIS_BMJ]

🧠 New insights for EVT coming from the 222 patients of the DISTAL trial: https://t.co/pDMuyfEoNx There is (statistically significant) higher reperfusion rates with a combined approach compared to ADAPT. However, ADAPT had numerically better functional outcomes and less symptomatic intracranial hemorrhage. What do YOU use for distal thrombectomy?

[JNIS @JNIS_BMJ]

Is endovascular therapy the future of brain tumor treatment? Emerging research on Yttrium-90 endovascular radiosurgery hints at a way to target tumors from within—crossing the BBB and sparing healthy tissue. Early signs point to this being a game-changing therapy! #NeuroOncology #neurointervention https://t.co/r3fcmRSHqV

[VJ Neurology @VJNeurology]

It was fantastic to hear from @pere_canals_ of @StanfordMed at #ESOC2025! Dr Canals presented his work investigating the impact of vascular anatomy on thrombectomy outcomes in distal/medium vessel occlusion.🎥

Check out the interview here:
👉 https://t.co/O5RTuPY8CJ

#Stroke

[Pere Canals 🍐 @pere_canals_]

Back to work from #ESOC2025!

Check out this brief that we recorded with @VJNeurology during the conference if you want to hear the core ideas of our research on the impact of vascular anatomy over thrombectomy outcomes in distal/medium vessel occlusion.

https://t.co/LjuBGIafjT

[AHA Science @AHAScience]

Mark your calendar for #ISC26 ⬇️

Don’t miss this chance to share your science and network with global experts at the world’s premier meeting dedicated to the science and treatment of cerebrovascular disease and brain health.

ISC chairs: @LaurenHSansing @bijoymenon

[Pere Canals 🍐 @pere_canals_]

I'm attending #ESOC2025 this week! I'm giving an oral presentation on Wednesday at 16:00h at the "Precision Imaging in Stroke" session on our work in Intracranial Vascular Tortuosity and its detrimental effects on thrombectomy for distal MeVOs.

Let's connect if you are around!

[European Stroke Org @ESOstroke]

#ESOC2025 starts tomorrow—but the conference centre in #Helsinki is already buzzing! Today’s Side Events include the ESO ICH Academy, the ESOTA Interactive Networking Session & WISE Networking Event

Details here 👉 https://t.co/jaW1ksWyc2

#VoiceOfStroke #Stroke #StrokeScience

[Thomas Wolf @Thom_Wolf]

We've just released the new Spaces search and it's totally mind blowing

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