Tony Perkis

@BernieSanders Our tax dollars are taken and flushed down the toilet. I think Jamie Dimon said it best. Not an exact quote but something along the lines of “our tax dollars are sent to Washington DC and then they hand it out to all their friends.” Our money enriches politicians.

Tony Perkis @Perkisystem_24

7 months ago

@hubermanlab Idc how many compounding pharmacies get spun up. It’s clinics and med spas sending prescriptions to the compounding pharmacy. So both the clinic/med spa & compounding pharmacy need to make money. It will be too expensive for the vast majority of ppl who want to use peptides.

Perkisystem_24 retweeted

Historic Vids

@historyinmemes

8 months ago

This is one of the most ice-cold, ruthless speeches in U.S. history.

889

42K

11K

Perkisystem_24 retweeted

Dave Portnoy

@stoolpresidente

8 months ago

1 more sleep. This is how me and my friends are feeling. #NEPats

138

141

203K

Perkisystem_24 retweeted

Bryan Johnson

@bryan_johnson

9 months ago

I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit. This has been obvious for years. AG1 has no real product substance and is fundamentally an influencer heist. Two simple alternatives (75% and 56% less $), outperform AG1 in randomized clinical trials. Two simple mono-ingredient alternatives that outperform AG1: 1. Chicory inulin 12 g daily ($20/mo) 2. Resistant starch 30 g daily for 12 weeks ($35/mo) AG1 is not worth $79/mo. AG1 study results (4-weeks, N=30): + No significant changes in blood biomarkers compared to placebo (CBC, CMP, lipids). + No statistically significant improvement in digestive quality-of-life scores (p = 0.058). + No significant metabolic or inflammatory biomarker benefits of any kind within the scope of what was measured in the trial. + Only small shifts in microbiome taxa but clinically irrelevant at this stage. + The intervention did not increase microbiome diversity compared to placebo. Alpha diversity was unchanged, and the taxa changes seen were only from pre- to post-analysis within each group. Between-group differences were limited, and the placebo actually showed similar or even potentially larger shifts. This means the observed changes fall within normal placebo-driven variability, not a real treatment effect. No global microbiota shifts were detected. Chicory inulin 12 g in constipation patients + 12 g of chicory inulin daily for 4 weeks (compared to maltodextrin placebo) + Global microbiota shifts: enrichment in butyrate-producing Bifidobacterium and Anaerostipes, and depletion of the pro-inflammatory Bilophila. +The effect was seen by comparing intervention vs placebo in a cross-over setting, a very rigorous type of clinical analysis in which each person serves as their own control, eliminating a lot of individual random noise. + The trial also met its primary objective by improving constipation symptoms in the targeted patient group. Resistant starch daily 30g for 12 weeks in older adults + Significant increase in Bifidobacterium in both middle-aged and elderly participants, with an increase in the beneficial microbiome byproduct butyrate, and reductions in Proteobacteria (including inflammatory Escherichia–Shigella) in the elderly. + Resistant starch also significantly reduced blood glucose, and produced greater reductions in blood insulin and insulin resistance (HOMA-IR) in the elderly group.

bryan_johnson's tweet photo. I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit.

This has been obvious for years. AG1 has no real product substance and is fundamentally an influencer heist.

Two simple alternatives (75% and 56% less $), outperform AG1 in randomized clinical trials.

Two simple mono-ingredient alternatives that outperform AG1:

1. Chicory inulin 12 g daily ($20/mo)
2. Resistant starch 30 g daily for 12 weeks ($35/mo)

AG1 is not worth $79/mo.

AG1 study results (4-weeks, N=30):
+ No significant changes in blood biomarkers compared to placebo (CBC, CMP, lipids).
+ No statistically significant improvement in digestive quality-of-life scores (p = 0.058).
+ No significant metabolic or inflammatory biomarker benefits of any kind within the scope of what was measured in the trial.
+ Only small shifts in microbiome taxa but clinically irrelevant at this stage.
+ The intervention did not increase microbiome diversity compared to placebo. Alpha diversity was unchanged, and the taxa changes seen were only from pre- to post-analysis within each group. Between-group differences were limited, and the placebo actually showed similar or even potentially larger shifts. This means the observed changes fall within normal placebo-driven variability, not a real treatment effect. No global microbiota shifts were detected.

Chicory inulin 12 g in constipation patients
+ 12 g of chicory inulin daily for 4 weeks (compared to maltodextrin placebo)
+ Global microbiota shifts: enrichment in butyrate-producing Bifidobacterium and Anaerostipes, and depletion of the pro-inflammatory Bilophila.
+The effect was seen by comparing intervention vs placebo in a cross-over setting, a very rigorous type of clinical analysis in which each person serves as their own control, eliminating a lot of individual random noise.
+ The trial also met its primary objective by improving constipation symptoms in the targeted patient group.

Resistant starch daily 30g for 12 weeks in older adults
+ Significant increase in Bifidobacterium in both middle-aged and elderly participants, with an increase in the beneficial microbiome byproduct butyrate, and reductions in Proteobacteria (including inflammatory Escherichia–Shigella) in the elderly.
+ Resistant starch also significantly reduced blood glucose, and produced greater reductions in blood insulin and insulin resistance (HOMA-IR) in the elderly group.

925

16K

801

Perkisystem_24 retweeted

Julian Edelman

@Edelman11

9 months ago

New England vs Everybody #GoPats

365

30K

Perkisystem_24 retweeted

Brett Krieger

@BrettKrieger12

9 months ago

Palantir Q4 earnings will be released on Monday, February 2nd IT’S SHOWTIME 🎬 $PLTR

169

648

174K

Tony Perkis @Perkisystem_24

10 months ago

Crypto is seemingly a dead asset class outside of 3 coins. I’m beginning to believe more and more that BTC, ETH & XRP are the only projects that truly add value to the world.

Tony Perkis @Perkisystem_24

10 months ago

@lukebelmar You’re a scammer

Perkisystem_24 retweeted

Bryan Johnson

@bryan_johnson

11 months ago

Sauna is one of the most effective health protocols I've done. Here is everything I've learned; it's the most robust characterization ever produced. Results: 1) Fifteen sessions of sauna dramatically reduced environmental toxins in my body: + 65% drop in 2,4-D + 100% drop in MEP + 15% drop in MBP + 100% drop in MEHP (undetectable post sauna) + 56% drop in NAPR + 56% drop in HEMA + 100% drop in Perchlorate (undetectable post sauna) 2. Sauna eliminated 85% of microplastics from my ejaculate. Nov 2024: 165 particles/mL July 2025: 20 particles/mL Nearly identical drop in my blood same time period: Oct 2024: 70 particles/mL May 2025: 10 particles/mL 3. Sauna, without ice on the boys, devastated my fertility markers. Total Motile Count: –56% Concentration: –30% Motility: –50% Morphology: –48% Count: –9% 4. Sauna coincided with my fertility markers being at an all-time high. I have more total and motile sperm than 99.6% of men of any age, including men under 25. + total count: 600 M + concentration: 162 M + motility: 55% + total motile count: 330M + morphology (normal): 10% We do not know what to make of these improvements. Was it the sauna? Sauna + ice? Ice only? We don't know but we did not identify any other protocols or lifestyle changes during this interval that would plausibly account for the change. 5. My vascular function improved by a ten year reduction in age. Now I have the vascular age of an elite 18-early 20s. + Central Systolic Blood Pressure: 96 mmHg + Central Pulse Pressure: 20 mmHg + Pulse Pressure Amplification: 160% + SEVR: 227% + Augmentation Pressure: 1 mmHg + Augmentation Index Wave: 3% + Traditional blood pressure: 107/75 mmHg 6. What type of sauna? Use a dry sauna with high temperatures between 80-100°C (176 to 212°F) and 5-20% relative air humidity. Aim for the lower end of this spectrum, especially as a beginner. Higher temperatures closer to the boiling point can cause side effects like headaches and severely dried nose and eyes. Note: Steam baths, hot tubs, and infrared saunas fail to replicate the same effects because they do not allow you to safely reach the required high temperatures and do not induce the same level of sweating, the necessary inverted (skin-to-core) temperature gradient, and the massive re-direction of blood to the skin with resulting vasodilation. Dry sauna is unique, and very likely superior to wet (steam bath) and infrared saunas. By heating up your skin way faster than your core, dry hot sauna flips your core skin temperature gradient, eliciting the following hormetic benefits: + enhanced blood flow: the heart pumps up to 70% more blood, similar to intense aerobic exercise (zone 2-+ increased sweating for detoxification: to maintain a stable core temperature, the skin produces 0.6-1 liter of sweat per hour, facilitating significant detoxification. + improved heat tolerance: the body becomes better at handling heat, leading to a lower core body temperature (offering metabolic advantages) + safe activation of heat shock proteins: the skin experiences substantial heat shock protein activation, while a modest 1°C increase in core temperature is sufficient to activate these proteins without the risk of hyperthermia. + extended Exposure at higher temperatures: dry saunas are more tolerable for longer durations and at higher temperatures, maximizing the benefits. 7. Sauna protocol and frequency Type: hot dry sauna Temperature: 176–212°F ( I do 200°F) Relative air humidity: very low, 5-20% Duration: 20 min Frequency: 4–7x a week 8. Heat Protection If you'd like, you can protect your head from the heat by wearing a sauna hat or wrapping it with a towel (use only cotton or other 100% natural material). You can breathe through a towel or cloth if needed to protect your nose. I am personally fine not doing this. Most importantly, ice the balls. Icing the testicles is absolutely required to prevent heat from damaging fertility markers. + Ice the testes during the sauna session. + Use a non-toxic, reusable ice pack material. + Wear cotton boxers and shorts. + Place ice packs in between the boxers and shorts. + Keep them in place for the entire session. Men should care about preserving fertility markers even when they are not trying to conceive. Sperm quality is tightly coupled to testicular function, which governs testosterone production, metabolic health, and long term endocrine stability. When fertility parameters decline, the same upstream dysfunction often drives lower testosterone, higher inflammation, and increased cardiometabolic risk. 9. Hydration Dry sauna induces sweating as part of its beneficial mechanism. Be sure to hydrate properly. In general, you might need to rehydrate with up to 16–32 oz (0.5–1 L) of fluid after a sauna session. Be sure to add electrolytes. If you want to be precise, measure your sweat amount and electrolytes (saltiness) using a patch (e.g., from Gatorade) to quantify your liquid and electrolyte loss, and rehydrate accordingly. Some people have saltier sweat than others and must ensure they replenish electrolytes as well as water. My results: my body sweats 18 oz during a 20 min sauna at 200 °F, with a sodium concentration of 25-39 mg/oz. A single sauna session flushes 450–700 mg of sodium out of my body. # I wish you all the best in life my friend. A new era or being human is here. One where existence is the highest virtue. Prioritize sleep, daily exercise and eat well and you'll be in a strong position. Try to avoid the bad stuff. Anything that takes away your agency. Be a warrior and caretaker of existence. Don't Die.

bryan_johnson's tweet photo. Sauna is one of the most effective health protocols I've done. Here is everything I've learned; it's the most robust characterization ever produced.

Results:

1) Fifteen sessions of sauna dramatically reduced environmental toxins in my body:

+ 65% drop in 2,4-D
+ 100% drop in MEP
+ 15% drop in MBP
+ 100% drop in MEHP (undetectable post sauna)
+ 56% drop in NAPR
+ 56% drop in HEMA
+ 100% drop in Perchlorate (undetectable post sauna)

2. Sauna eliminated 85% of microplastics from my ejaculate.

Nov 2024:
165 particles/mL
July 2025: 20 particles/mL

Nearly identical drop in my blood same time period:
Oct 2024: 70 particles/mL
May 2025: 10 particles/mL

3. Sauna, without ice on the boys, devastated my fertility markers.

Total Motile Count: –56%
Concentration: –30%
Motility: –50%
Morphology: –48%
Count: –9%

4. Sauna coincided with my fertility markers being at an all-time high. I have more total and motile sperm than 99.6% of men of any age, including men under 25.

+ total count: 600 M
+ concentration: 162 M
+ motility: 55%
+ total motile count: 330M
+ morphology (normal): 10%

We do not know what to make of these improvements. Was it the sauna? Sauna + ice? Ice only? We don't know but we did not identify any other protocols or lifestyle changes during this interval that would plausibly account for the change.

5. My vascular function improved by a ten year reduction in age. Now I have the vascular age of an elite 18-early 20s.

+ Central Systolic Blood Pressure: 96 mmHg
+ Central Pulse Pressure: 20 mmHg
+ Pulse Pressure Amplification: 160%
+ SEVR: 227%
+ Augmentation Pressure: 1 mmHg
+ Augmentation Index Wave: 3%
+ Traditional blood pressure: 107/75 mmHg

6. What type of sauna?
Use a dry sauna with high temperatures between 80-100°C (176 to 212°F) and 5-20% relative air humidity. Aim for the lower end of this spectrum, especially as a beginner. Higher temperatures closer to the boiling point can cause side effects like headaches and severely dried nose and eyes.

Note: Steam baths, hot tubs, and infrared saunas fail to replicate the same effects because they do not allow you to safely reach the required high temperatures and do not induce the same level of sweating, the necessary inverted (skin-to-core) temperature gradient, and the massive re-direction of blood to the skin with resulting vasodilation.

Dry sauna is unique, and very likely superior to wet (steam bath) and infrared saunas. By heating up your skin way faster than your core, dry hot sauna flips your core skin temperature gradient, eliciting the following hormetic benefits:

+ enhanced blood flow: the heart pumps up to 70% more blood, similar to intense aerobic exercise (zone 2-+ increased sweating for detoxification: to maintain a stable core temperature, the skin produces 0.6-1 liter of sweat per hour, facilitating significant detoxification.
+ improved heat tolerance: the body becomes better at handling heat, leading to a lower core body temperature (offering metabolic advantages)
+ safe activation of heat shock proteins: the skin experiences substantial heat shock protein activation, while a modest 1°C increase in core temperature is sufficient to activate these proteins without the risk of hyperthermia.
+ extended Exposure at higher temperatures: dry saunas are more tolerable for longer durations and at higher temperatures, maximizing the benefits.

7. Sauna protocol and frequency
Type: hot dry sauna
Temperature: 176–212°F ( I do 200°F)
Relative air humidity: very low, 5-20%
Duration: 20 min
Frequency: 4–7x a week

8. Heat Protection

If you'd like, you can protect your head from the heat by wearing a sauna hat or wrapping it with a towel (use only cotton or other 100% natural material). You can breathe through a towel or cloth if needed to protect your nose. I am personally fine not doing this.

Most importantly, ice the balls.

Icing the testicles is absolutely required to prevent heat from damaging fertility markers.

+ Ice the testes during the sauna session.
+ Use a non-toxic, reusable ice pack material.
+ Wear cotton boxers and shorts.
+ Place ice packs in between the boxers and shorts.
+ Keep them in place for the entire session.

Men should care about preserving fertility markers even when they are not trying to conceive. Sperm quality is tightly coupled to testicular function, which governs testosterone production, metabolic health, and long term endocrine stability. When fertility parameters decline, the same upstream dysfunction often drives lower testosterone, higher inflammation, and increased cardiometabolic risk.

9. Hydration

Dry sauna induces sweating as part of its beneficial mechanism. Be sure to hydrate properly. In general, you might need to rehydrate with up to 16–32 oz (0.5–1 L) of fluid after a sauna session. Be sure to add electrolytes.

If you want to be precise, measure your sweat amount and electrolytes (saltiness) using a patch (e.g., from Gatorade) to quantify your liquid and electrolyte loss, and rehydrate accordingly. Some people have saltier sweat than others and must ensure they replenish electrolytes as well as water.

My results: my body sweats 18 oz during a 20 min sauna at 200 °F, with a sodium concentration of 25-39 mg/oz. A single sauna session flushes 450–700 mg of sodium out of my body.

#

I wish you all the best in life my friend. A new era or being human is here. One where existence is the highest virtue. Prioritize sleep, daily exercise and eat well and you'll be in a strong position. Try to avoid the bad stuff. Anything that takes away your agency.

Be a warrior and caretaker of existence. Don't Die.

912

20K

23K

Perkisystem_24 retweeted

Tucker Carlson

@TuckerCarlson

11 months ago

Once you understand just how destructive cannabis is to young men, it’s hard not to see it as a tool of social control. Dr. Daniel Amen explains. (0:00) How Does Marijuana Affect the Brain? (3:03) The Connection Between Marijuana and Psychosis (12:35) Why Is Brain Damage on the Rise? (15:18) Psychosis and Schizophrenia (21:58) Does Obesity Decrease the Size of Your Brain? (24:45) What Does Marijuana Do to Testosterone Levels? (25:11) Is This Contributing to the Rise of Autism? (31:41) Don't Believe Everything You Think (34:08) Is Marijuana a Medicine? (38:23) Should Marijuana Be Legal? (40:41) Is Marijuana Ruining Your Marriage? (44:51) Does Marijuana Increase Your Risk of Dementia? (55:00) Why Isn’t the Government Sounding the Alarm About Marijuana? (57:02) The Increase in Mushroom Use and Its Risks (1:02:14) What Is Kratom? (1:07:05) AI Is Destroying Your Brain (1:13:40) The Spiritual Impact of an Unhealthy Brain (1:16:10) How Hard Is It to Get Off Marijuana? (1:21:08) How to Protect Your Brain (1:28:48) Did Covid Damage Your Brain? (1:31:28) Can You Reverse Brain Damage? (1:34:31) Why Is There a Rise in Alzheimer's? (1:36:52) How to Manage Your Mind (1:47:20) Is Violence the Result of an Unhealthy Brain? Includes paid partnerships.