Khanh Phan

Royal Society of Tropical Medicine and Hygiene (RSTMH) and National Institute for Health Research (NIHR) early career researcher.

[Khanh Phan @phan189]

@rlmcelreath Thank you so much sharing. Really enjoying this year

[Marios Georgakis @MariosGeorgakis]

I'm often asked how human genetics can be used to validate drug targets.

In our new @NatureCVR paper, we provide an end-to-end framework for IL-6 inhibition🧵
👉build a genetic proxy
👉demonstrate potential for cardiovascular benefit
👉assess expected & unexpected safety signals

[Adam Grant @AdamMGrant]

"Don't bring me problems, bring me solutions" doesn't eliminate problems. It stops people from raising the hardest problems.

Leaders need to hear what's broken even if the fix is unclear.

A better option: “Bring me problems, as long as you’re willing to be part of the solution"

[Khanh Phan @phan189]

@tangming2005 Or hit "Ignore conversation" :)

[Khanh Phan @phan189]

@tangming2005 Thanks Tommy, I can see myself in so many of your examples. It is good to know that I am not alone :)

[Khanh Phan @phan189]

@tangming2005 This is so true, and I learned something new today. Thanks Tommy

[Khanh Phan @phan189]

@tangming2005 The fact that you can plot that Venn is impressive Tommy. Although with such complex intersection, upset plot is obviously better for reading.

[Khanh Phan @phan189]

@tangming2005 Thanks Tommy, very useful thread as always. I would also add that mismatch gene id with gene symbol can happen with different annotation version as well. It might occur when you were handed an old dataset without proper documentation.

[Khanh Phan @phan189]

@MariosGeorgakis Thank you for an interesting article. It seems from panel D-E, youthful brain group has a lower risk of mortality -which is both surprising and positive.

[Khanh Phan @phan189]

@jermdemo well if it's a case-control GWAS, reverse the trait to "attractiveness to mosquito" sounds more interesting and positive to me :)

[Khanh Phan @phan189]

@kjaganatha Thank you for sharing, Kishore. It looks very promising. One question, can we input a list of SNP (id or position) and check how they can influence gene expression?

[Khanh Phan @phan189]

@tangming2005 Thank you @tangming2005 , very useful threads as always.

[Khanh Phan @phan189]

@tangming2005 Thanks Tommy, one of the confusing for topics for anyone just start RNAseq

[Khanh Phan @phan189]

@GeostatsGuy @matplotlib You're amazing. Thank you so much for these valuable resources

[Khanh Phan @phan189]

@MariosGeorgakis Thank you Marios for sharing, truly amazing to see integration of multiple-omics at such large sample size.

[Khanh Phan @phan189]

@tangming2005 Very well said as always, Tommy. I would add 1 more thing: use seed number (set.seed) so you can reproduce result/plot as certain bioinformatics tools rely on randomness.

[Khanh Phan @phan189]

@ariellefilomena When the stars align!

[Khanh Phan @phan189]

@DrNeilStone Not to forget that even with modern medicine support, patients (who did not get adequate vaccination) spend 2-3 weeks in ICU.

[Khanh Phan @phan189]

@drleighannjones Good luck Leigh, and may the airline gods smile upon you!

[Khanh Phan @phan189]

@MariosGeorgakis Fascinating, thank you for sharing @MariosGeorgakis