Reg Myers

[Michael Albert, MD @MichaelAlbertMD]

Zero.
I read it three times to be sure.
For five straight years, not one young woman in England has died of cervical cancer. 🧵

[Reg Myers @pharma_reg]

@arya_stark47 Cedar. Hit-and-Hit. Handmade (by me).

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Mark Lewis, MD, FASCO @marklewismd]

Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer

Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived

#ASCO26

[Dr Singularity @Dr_Singularity]

New Quanta article looks at one of the coolest tiny machines in biology - the bacterial flagellar motor. It’s basically a microscopic spinning engine that bacteria use to move.

After decades of trying to fully understand it, scientists are finally figuring out how it actually works. The motor is powered by a flow of charged particles (kind of like a tiny battery), which creates force and makes it rotate.

So what looks like something alive and mysterious is really just an incredibly advanced microscopic machine running on the same basic rules as everything else.

More broadly, the article addresses the idea of a "life force." It argues that no special force is needed to explain life. Instead, biological activity arises from physical processes that operate far from equilibrium, where constant energy flow keeps the system active and organized.

The flagellar motor shows that living systems can be understood as energy driven, self organizing systems. What appears to be uniquely "alive" can be explained by standard physical laws, such as thermodynamics and molecular interactions.

Physics pushed to an extreme level of complexity.

[Reg Myers @pharma_reg]

@drakefjustin Just add an extra ‘!’ at the end and it’ll be fine… 🤣😂

[Reg Myers @pharma_reg]

@AppleHelix If you start looking at it from a tumor-cell access (immune cell infiltration) perspective, it may change the way you interpret some of the data. Genentech never did explain bev efficacy. VEGF-a isoform was once investigated as a biomarker in equivocal tumor types.

[Reg Myers @pharma_reg]

@AppleHelix From memory - going back 15+ years (think Avastin adjuvant) - the vasculature normalization hypothesis appeared more credible than anti-angiogenic/anti-tumor wrt to chemo (bolus/infusion) partner and sq (deeper, bulkier tumors but more prone to bleeds) vs non-sq clinical data.

[Watching From The Sidelines @NeedsMustBeFed]

@Feargal_Sharkey https://t.co/eLhIKnFHlD

[Reg Myers @pharma_reg]

@JaneSymons1 @British_Airways Have you tried logging-in twice, confirming you’re a human 3 times, and at least 4 ‘hail Mary’s’ ?

[Reg Myers @pharma_reg]

@virginmedia @E811914461530 @Ofcom My mate Dave says it’s fine as long as whoever wrote the advert had their fingers crossed behind their back at the time…

[Reg Myers @pharma_reg]

@the_blind_thing Looks like @CambsCC are having a go too… just a little less successfully… not sure what genre of music they were going for… #potholes

[Reg Myers @pharma_reg]

Skynet probing for weakness…

[Weapon 𝕏 @HellRaz0r1776]

My roomba just beat me to a Cheeto that I dropped on the floor.

This is how the war against machines begins

[Reg Myers @pharma_reg]

@henryfraser0 Absolute LEGEND! Nice one.

[Reg Myers @pharma_reg]

@bankertobuilder Silicone smoothing tools….? no mate… I just used my big toe 😂

[Kartos Therapeutics @KartosThera]

The POIESIS Trial is seeking participants aged 18+ for a large global Phase 3 study in patients with myelofibrosis who have never been treated with a JAK inhibitor.

Want to know more? Visit us today!

[Dr. Jonathan N. Stea @jonathanstea]

Brandolini’s Law (also known as the bullshit asymmetry principle):

The amount of energy needed to refute bullshit is an order of magnitude bigger than that needed to produce it.

[Robert Y. Chen @therealRYC]

🚨 The older the sperm, the more likely it is to cause autism

Sequencing sperm using nearly error-free sequencing → measure % sperm carrying disease-causing mutations:

2% at age 30 → 4.5% at 70

Most were autism genes

New paper in @Nature today 🧵

[Keith Burge @carryonkeith]

"Hi, is that 'We Buy Any Yacht'?"