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Bristol Myers Squibb and Hengrui Pharma have announced the second-largest pharma cooperation agreement (and China’s second-largest pharma deal overall)
China is driving small interfering RNA (siRNA) licensing activity, accounting for 40% of global transactions this decade. In line with this trend, the country has recently experienced a surge in overseas demand for its siRNA therapies, mainly driven by Big Pharma.
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Although no one can match Pfizer’s USD 43b purchase of Seagen, Gilead Sciences has so far committed USD 26b to the ADC field following its acquisition of Tubulis GmbH for up to USD 5b (Gilead’s second, and the fifth-largest overall M&A transaction for an ADC company)
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The third-largest China-outbound AI drug discovery deal has been announced by Insilico Medicine and metabolic disease expert Eli Lilly and Company, with a value of up to USD 2.75b, as the companies upgrade a 2025 collaboration worth USD 99m
Eli Lilly and Company has just closed the largest deal in the OX2R agonist space, acquiring neuroscience specialist Centessa Pharmaceuticals along with its OX2R portfolio for USD 7.8b (USD 6.3b upfront).
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With the potential to treat thousands of rare diseases using a single drug, tRNA therapies represent the third wave of RNA therapeutics. This technology is now entering the clinic for the first time, with Alltrna receiving approval to advance AP003 to human trials in Australia