Phil Jean-Richard-dit-Bressel

Behavioural neuroscientist / Experimental psychologist @ UNSW Sydney

[Phil Jean-Richard-dit-Bressel @philJRDB]

For more updates: https://t.co/ydMmZ9nuNL

[Phil Jean-Richard-dit-Bressel @philJRDB]

New paper from lab on VTA dopamine + GABA inputs in punishment learning
https://t.co/qRU8q4KhP2

TL;DR here:
https://t.co/3OSSXWvLTv

[Phil Jean-Richard-dit-Bressel @philJRDB]

If you missed it - this finally got published (with some cool new Supplementary data!)
https://t.co/LZDEPlwENN

[Phil Jean-Richard-dit-Bressel @philJRDB]

I don't usually broadcast preprints, but thinking this should be exception (in case it helps now) https://t.co/MfzoSZ4OUY

Isosbestic signals are used to artifact-correct experimental signals in fibre photometry, often by OLS regression. Inherent problems with this approach. 1/

[Phil Jean-Richard-dit-Bressel @philJRDB]

New paper from lab: https://t.co/zgvS6QUrNe

Posted about here: https://t.co/cBbpNPPau6

[Phil Jean-Richard-dit-Bressel @philJRDB]

I'm glad my last interactions with her were good ones.

If there's any takeaway from this, its to never forget to tell those you love how much they mean to you.

[Phil Jean-Richard-dit-Bressel @philJRDB]

I don't usually post personal stuff here, but my mum passed away last week and I wanted to share a little about how she's the reason I do what I do.

[Phil Jean-Richard-dit-Bressel @philJRDB]

I too had a complicated relationship with her, even from childhood. I studied psych in part to better understand and maybe help her. I dont think that goal was ever achieved. I wish I'd had more time.

[Rachel Smith @RachelSmith_PhD]

New pub: We saw greater punishment resistance for cocaine with RI60 schedule vs RR20. With food, similar results in ♀️ but ♂️ resistant with RR20 and RI60. @AdelisCruz_PhD @morg_palz @SophiaN_Handel

Special issue on Punishment in NLM edited by @philJRDB

https://t.co/CY5f8v5IpA

[Phil Jean-Richard-dit-Bressel @philJRDB]

@PessoaBrain Risk-avoidance is fundamentally associative. Or have I completely misunderstood your meaning?

[Phil Jean-Richard-dit-Bressel @philJRDB]

@Pop_Watson Would've been fun! Anything u want me to channel on your behalf for the symposium?

[Dr. Millie Rincón-Cortés 🇵🇷 @houseofmind]

Next year's @IBNSconnect will be in Norway!!!

[Phil Jean-Richard-dit-Bressel @philJRDB]

Interested in punishment/BLA/miniscopes?
Come by my poster tomorrow morning!

Interested in compulsive-like behaviour?
Join our symposium + "debate" Fri 11am-1pm

Interested in integrating teaching & research?
E&T session Fri afternoon
#IBNS2024

[Phil Jean-Richard-dit-Bressel @philJRDB]

Took a slight detour on my way to #IBNS2024

[Nick Everett @neuronick_]

https://t.co/eOND4sIxWZ
Apply here, closes 5 Feb ☝️

We are looking for someone who has experience conducting and analysing in vivo neural recordings, preferably fibre photometry.

Rat social behaviour/conditioning experience will be advantageous.

Interest in drug dev ideal!

[IBNS @IBNSconnect]

Ready to TRAVEL to Panama? Apply for an IBNS TRAVEL Award Today!
https://t.co/QjJHl9YyCh
#IBNS2024 #IBNSConnect

[Phil Jean-Richard-dit-Bressel @philJRDB]

@samamckenzie @DautanDaniel Sure! Feel free to send more details. I think only case dF matches dF/F is if there's no photobleaching. But if just looking at average transient across session + no temporal confound of events being compared, dF still not preferable but works (eg mean IRLS dF vs dF/F in fig)

[Phil Jean-Richard-dit-Bressel @philJRDB]

I don't usually broadcast preprints, but thinking this should be exception (in case it helps now) https://t.co/MfzoSZ4OUY

Isosbestic signals are used to artifact-correct experimental signals in fibre photometry, often by OLS regression. Inherent problems with this approach. 1/

[Phil Jean-Richard-dit-Bressel @philJRDB]

@samamckenzie @DautanDaniel Its a good q. I dont know of a solution I'm fully satisfied with. We explored some ideas but they didnt clear theoretical+empirical bar. Maybe rescaling each signal by their baseline decay before fitting? Not without some v difficult assumptions, but could be worth exploring..

[Phil Jean-Richard-dit-Bressel @philJRDB]

@DautanDaniel Differential bleaching is tricky. I dont think any current solutions fully address it, eg. detrending signals first comes with own problems (in preprint). I still favour IRLS over OLS under this condition.

Interesting you see less bleaching for isosbestic - most see opposite