Phil Hayes

founder TAV & genAI @meta past @X @Airbnb adjunct @nyustern

[Phil Hayes @phlhayes]

@RalphHolzmann @zachmoskow This made my day @jarzod good morning

[Dr. Rhonda Patrick @foundmyfitness]

Sauna use may reduce dementia and Alzheimer's risk. Since the data has made this case, the question is why?

There may be a few mechanisms at play:
• Sauna use improves vascular health and blood pressure - both interventional and observational studies support this.
• Heat shock proteins produced in response to heat stress may prevent the damaging neurodegenerative effects of protein aggregation.

Poor vascular health plays a role in breakdown of the blood-brain barrier - one of the earliest signs of dementia. Improving and sustaining vascular health may be immensely important for protecting cognition.

Sauna use strongly activates heat shock proteins. For instance, spending 30 minutes at 163°F can boost their levels by 50% from the baseline. These heat shock proteins help prevent protein aggregation in the brain, a factor linked to neuroinflammation and Alzheimer's disease.

The caveat is that observational data is at play here.
We probably won't see a randomized controlled trial studying the effects of sauna use on dementia risk spanning several decades. Thus, the best evidence we have for saunas in this respect comes from a combination of observational data and studies examining biomarkers associated with dementia.

While we still can't say definitively this isn't healthy user bias in some form, the variety of mechanisms at play at the least make a case for that being relatively unlikely and generally support sauna more broadly as at the least a healthy lifestyle habit.

If you don't have access to a sauna, you can still enjoy the benefits of a heat shock response through a hot bath. 104ºF for at least 20 minutes seems to be a good threshold for inducing the expression of heat shock proteins.

Discussion of hot bath vs. sauna:
https://t.co/ApjYjw2Soh

Broad overview on sauna available here:
https://t.co/Op0M1eBEpS

[Yaron Samid 🇮🇱🇺🇸 @yaronsamid]

In my 50 years, I have never been more proud to be an American. President Biden's remarkable speech moments ago will go down in history as one of his best ever and the most impactful support of Israel’s right to defend itself “decisively and overwhelming” against those bent on its destruction. Thank you, @POTUS, for your world leadership.

Biden: "There are moments in this life when the pure, unadulterated evil is unleashed. The people of Israel lived through one such moment this weekend. The bloody hands of the terrorist organization Hamas, a group whose stated purpose is to kill Jews. This was an act of sheer evil.

So, in this moment, we must be crystal clear. We stand with Israel. There is no justification for terrorism. There is no excuse. Hamas does not stand for the Palestinian people’s right to dignity and self-determination."

There is no mincing words: HAMAS = ISIS, and we will dismantle and destroy them accordingly. Decide what side of history you are on as we do.

FULL SPEECH BELOW

🇺🇸 🇮🇱
#HamasISIS
#Israel_under_attack
#AmIsraelChai

[Phil Hayes @phlhayes]

@_aj @KindredVentures @Initialized Congrats @_aj @MiguelriosEN!

[Phil Hayes @phlhayes]

Airbnb not having filters for Tennis courts or saunas (on property or nearby) is a big miss

[Phil Hayes @phlhayes]

@hanslorei Do you have any STR design services that you would recommend?

[Rex Woodbury @rex_woodbury]

Interesting new Gen Z study:

Only 51% of Gen Zs want to pursue a 4-year college, down from 71% two years ago. 56% would prefer a skills-based education.

Feels like the demand is there for more lifelong, job-specific learning—but supply will probably take a while to catch up.

Source: @thefutureparty

[Jane Manchun Wong @wongmjane]

@elonmusk Those spammy disposable ad accounts created in bulk to show us low quality product ads should also be eradicated

[True Discipline @TruueDiscipline]

How successful were other countries attempts to raise fertility? Sweden: https://t.co/j2rx8tWh3y

[Phil Hayes @phlhayes]

@singareddynm Happy birthday Nikita!

[Soren Iverson @soren_iverson]

A JUUL app with parental controls.

[Nicholas Kyrgios @NickKyrgios]

Watching Novak tonight makes me feel good about my tennis in general 🤣 how have I beaten this guy 🤣

[Gergely Orosz @GergelyOrosz]

One of the most underrated languages to learn - that is surprisingly fast to do: SQL.

The language has a handful of operators. They take some - but not too much - time to understand and master.

Once you know how to join, group, union, create a view: that’s all you need really.

[Phil Hayes @phlhayes]

@nicolehenrysmom

[Genevieve Roch-Decter, CFA @GRDecter]

The Fed may be raising interest rates, but their balance sheet still looks like this

[Phil Hayes @phlhayes]

@lexfridman Twitter literally had this a month ago. Top trends in the US had a human-authored description. The team that wrote these descriptions (and helped link related trends together) was fired

[ian bremmer @ianbremmer]

houston, we have a population problem

[Phil Hayes @phlhayes]

@samhaves @Patreon Congrats Sam!!

[Ed Husain @Ed_Husain]

A new Middle East is being born.
Look how young Iranians are treating an Israeli reporter: