Crick researchers have mapped the effects of all potential changes in a specific tumour-suppressing gene.
This could help clinicians work out which patients are more at risk of developing kidney cancer or how responsive they’ll be to treatment.
https://t.co/wHqhK1ImQw
NEW! Our first @biorxivpreprint from @TheCrick, led by @megan_buckley01:
https://t.co/OJf0PMDRjd
"Saturation Genome Editing Resolves the Functional Spectrum of Pathogenic VHL Alleles"
We present a high-quality variant effect map of VHL to advance precision medicine.
(1/18)
We're hiring a senior scientist to tackle the challenge of assaying 10,000s of human variants across diverse cellular models. 🧬 ✂️🧪✂️ 🧬
https://t.co/lYA1Wmn0uE
Please RT + DM if interested.
Looking forward to presenting our latest work at the Festival of Genomics & BioData, January 25-26th in London. Registration is free, so come join us and say hi to the lab.
More info: https://t.co/90uvf1xd5d
#FOG2023
Our newly minted review led by Crick PhD student Phoebe Dace puts the research we do in the context of clinical variant interpretation and serves as an excellent primer on Saturation Genome Editing and other multiplex functional assays.
https://t.co/O9RaFu183L @degruyter_pub