Pijush Chakraborty

Researcher @AstburyCentre |Ph.D. @dzne_en| alumni @mpi_nat @uniGoettingen @iitbbs| Structural Biology/IDPs/Protein aggregation/Neurodegeneration|#ProudIndian

[Pijush Chakraborty @pijush_c]

🇮🇳🇮🇳🇮🇳

[Sachin Tendulkar @sachin_rt]

Chak De India!!!! 🇮🇳🇮🇳🇮🇳🇮🇳💙🏆

[Suzanne E Schindler @SuzanneESchind1]

Alzheimer’s blood test performs as well as FDA-approved spinal fluid tests https://t.co/lq8H4olW8G via @wustlmed

[Pijush Chakraborty @pijush_c]

@SamratLabMohali Great news! Congratulations, Samrat!!

[Pijush Chakraborty @pijush_c]

Auf Wiedersehen Göttingen!!!!

[Markus Zweckstetter @mz_science]

Ending 2023 in style: Hsp90-Independent cochaperone-mediated regulation of Tau aggregation: fantastic work from Pijush Chakraborty
https://t.co/PNG64jMfU8

[Pijush Chakraborty @pijush_c]

@SamratLabMohali Congratulations, Samrat !!!

[Markus Zweckstetter @mz_science]

A direct link between Tau phosphorylation by GSK3beta, #Tau condensation and #AlzheimersDisease 's Disease Tau Fold: stellar work from Pijush Chakraborty in collaboration with the lab of Ben Wolozin https://t.co/ZSGcyuH1sy

[Alzforum @alzforum]

Acetylation fuels aggregation of three-repeat tau yet slows that of four-repeat tau. Why? Acetylated lysines in a segment unique to 4R tau disrupt fibril cores. @DZNE_en https://t.co/34XBKAZlWL

[Markus Zweckstetter @mz_science]

Why does only 3R Tau form insoluble deposits in Pick's disease? Stellar work from Pijush Chakraborty shows that acetylation promotes aggregation of 3R Tau but blocks aggregation of 4R Tau.

https://t.co/fdApM2lJq5

[Pijush Chakraborty @pijush_c]

@SamratLabMohali @insa_academy Many Congratulations, Samrat!

[Pijush Chakraborty @pijush_c]

@samiriisc @IITGuwahati Congratulations, Samir da!

[Markus Zweckstetter @mz_science]

Some thoughts on the role of aberrant phase separation!

[ISRO @isro]

Chandrayaan-3 Mission:
'India🇮🇳,
I reached my destination
and you too!'
: Chandrayaan-3

Chandrayaan-3 has successfully
soft-landed on the moon 🌖!.

Congratulations, India���🇳!

#Chandrayaan_3
#Ch3

[Pijush Chakraborty @pijush_c]

@Hlashuel @NatureComms @LashuelLab Thanks for your reply! The kinetic profiles are the same. We didn't publish it as we are sure that the main driving force behind the aggregation is the PTFE beads (mechanical agitation + surface charges). So, we are not using the cocktail inhibitor for subsequent studies.

[Pijush Chakraborty @pijush_c]

@Hlashuel @NatureComms @LashuelLab (4/4)I guess in our method the aggregation of tau might also be triggered by the partial negative charges present on the surface of the PTFE beads.

[Pijush Chakraborty @pijush_c]

@Hlashuel @NatureComms @LashuelLab (3/4) However, the presence or absence of the protease inhibitor doesn't make any difference in the kinetics of the aggregation assay and the fibrils produced in the absence/presence of the inhibitor are the same (we even don't use the inhibitor anymore in our aggregation assays)

[Markus Zweckstetter @mz_science]

Spearheaded by Taekyung Yu, we show how synaptogyrin shapes synaptic vesicles to allow for precise storage of neurotransmitters https://t.co/yh6wXZ4KS9

[Ruben Dario Palacio, Ph.D. @rdpalacio]

Science is hard.

Good research makes you feel stupid.

You're inadequate for the task at hand.

How else would it be? You're pushing the boundaries of knowledge.

Get used to it. This process is immensely rewarding.