StoP-AD Center

Center for Studies on the Prevention of Alzheimer's disease, McGill University, Montréal, Qc, Canada. AD dementia, biomarkers, prevention.

[Sylvia Villeneuve @sylv_villeneuve]

1/5 We are about to release the PREVENT-AD Stage 2 open dataset that will include PET, MEG, … and 5 yrs of additional cognitive FU. 🥳 @alexa_pichetb @prevent_ad

[JAMA Neurology @JAMANeuro]

Study found that Aβ and tau PET positivity in cognitively unimpaired individuals was associated with near-term progression to mild cognitive impairment and, among those who do not show such categorical change, longitudinal cognitive decline. https://t.co/sKpST7e4Nh

[Sylvia Villeneuve @sylv_villeneuve]

1/3 New lab paper suggesting, in 4 independent cohorts of cognitively unimpaired individuals, that the presence of both amyloid and tau-PET positivity is associated with near-term #AlzheimersDisease clinical progression. Strong support for the NIA-AA preclinical research criteria

[Sylvia Villeneuve @sylv_villeneuve]

Our most important clinical paper so far. In the @prevent_ad, 60% of our cognitively unimpaired participants with amyoid and tau PET binding developed MCI in ~2 years, a number that increased to 80% in those with hippocampal atrophy. The findings are replicated in 3 cohorts.

[Douglas Research Centre @DouglasResearch]

New article from @sylv_villeneuve 's team, @prevent_ad in @NatureComms

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
https://t.co/cOnIY5gjtV

#alzheimer #brain #amyloidosis #aging #MachineLearning

[Iturria-Medina @MedinYasser]

Looking for motivated Data Analyst for multimodal analyses in neurodegeneration (e.g. Alzheimer's). Mathematical, statistical, machine-learning skills and interest in neurobiology are requirements. For details, please check https://t.co/xhPxyvqnLV

[Douglas Research Centre @DouglasResearch]

Six of our researchers obtain a CIHR Project Grants
Congratulations @markpaulbrandon @MCGeoffroy R. Mizrahi, J. Poirier, @pedrorosaneto @sylv_villeneuve
https://t.co/VF147j8nHH

[Julie Gonneaud @julie_gonn]

PhD opportunity‼️

I am looking for a #PhD student to investigate the influence of #lifestyle on #cognition & #neuroimaging markers of #ageing and #Alzheimer

Access to the offer and application details below 👇

[StoP-AD Center @prevent_ad]

Find out what the PREVENT-AD is, what data is made openly available and where to get it @NeuroLibre! Thank you to all who contributed to acquire and make this data available. We look forward to the community using the data! #openscience https://t.co/ZHt1UE4ZoM

[Nat Rev Neurology @NatRevNeurol]

Open Science Datasets from PREVENT-AD, a Longitudinal Cohort of Pre-symptomatic Alzheimer’s Disease https://t.co/JIQvaBT2eE

[Sylvia Villeneuve @sylv_villeneuve]

McGill to me: “I am pleased to inform you that the Board of Governors of McGill University has approved the grant of tenure and the promotion to the rank of Associate Professor to you...” I GOT MY TENURE !!

[Iturria-Medina @MedinYasser]

Paper in @elife: How whole-brain gene transcripts drive interactions among tau, amyloid, CBF, structural changes and pathology spreading in Alzheimer’s and Aging? Results from multi-scale universal formulation, by brilliant PhD-candidate @technoryta, https://t.co/9Msuwktzh6

[Sylvia Villeneuve @sylv_villeneuve]

Another beautiful paper by @alexa_pichetb in collaboration with @maxdescoteaux using novel pipelines from @scil_udes. https://t.co/7SAW8APiCl @eLife @mcgillu @DouglasResearch @prevent_ad #Alzheimers #STEM #amyloid #tau

[BHEAM Lab @BheamLab]

Congrats to @SivaniyaSubram for acceptance of her paper “Sex differences in brain aging among adults with family history of Alzheimer’s Disease and APOE4 genetic risk” w @j_snytte in collaboration w @arossotto @EinsteinLabUofT in NIMG:Clinical! Stay tuned for #openaccess link!

[StoP-AD Center @prevent_ad]

@Raamana_ @sylv_villeneuve Hey Pradeep! We have started on some of this already :) Have you looked at our preprint? https://t.co/8Sr6apg6Ke

[Sylvia Villeneuve @sylv_villeneuve]

New paper from the lab suggesting that vascular risk factors are associated with a decline in resting-state functional connectivity over time in the @prevent_ad cohort. Vascular risk factors should really be more targeted for healthy aging and AD prevention.

[Theresa Köbe @TheresaKobe]

Proud to present our latest findings on the association between vascular risk factors and longitudinal resting-state functional connectivity in @prevent_ad! All my thanks goes to such a great team @sylv_villeneuve, @alexa_pichetb, @_JakeVogel_, @pf_meyer https://t.co/nxTBmZusvD

[StoP-AD Center @prevent_ad]

You can access more of the PREVENT-AD data openly! A lot of work has gone into this, particularly from @sylv_villeneuve’s team. It was a lot work but we are delighted to share this with you! #openscience

[Sylvia Villeneuve @sylv_villeneuve]

1/14 Once upon a time (>2 years ago), we started the journey of making the PREVENT-AD data open. We had to reconsent the participants, develop the platform to host and share the data (thanks to Alan Evans and @NeuroLibre teams), clean the data and create the data dictionary.