PRISM Trial

Prevention of respiratory insuffiency after surgical management (PRISM) trial: an international multi-centre RCT of CPAP after major abdominal surgery.

[Tom Abbott @_tomabbott]

8/ A big thank you to our international teams of investigators across Europe & South Africa and to our funders @NIHRresearch @Barts_Charity @Assoc_Anaes @intersurgical & @unirome1 Thank you! @IbJammer @BruceBiccard @caldecoaal @iamyourgasman @prismtrial @CCPMG_TEAM

[Tom Abbott @_tomabbott]

7/ The results of @prismtrial do not support the routine use of postoperative CPAP to prevent pneumonia, re-intubation or death after major abdominal surgery. https://t.co/l5MK91549y @rupert_pearse @CCPMG_TEAM @QMULWHRI @QMULBartsTheLon

[Tom Abbott @_tomabbott]

6/ We found no differences between CPAP and standard postoperative care for any of our pre-specified secondary outcomes. https://t.co/l5MK91549y @prismtrial

[Tom Abbott @_tomabbott]

5/ 8.1% of patients in the CPAP group met the primary outcome of pneumonia, re-intubation or death within 30 days after randomisation compared to 8.2% of patients in the usual care group (odds ratio 1.01, p=0.95). https://t.co/l5MK91549y @prismtrial

[Tom Abbott @_tomabbott]

4/ The primary outcome was a composite of pneumonia, endotracheal re-intubation or death within 30 days after randomisation. We undertook an intention to treat analysis according to published protocol https://t.co/ahYacqTo1K @prismtrial

[Tom Abbott @_tomabbott]

3/ Patients were randomly assigned to receive either Continuous Positive Airway Pressure (CPAP) within 4hr after the end of surgery or usual postoperative care. @prismtrial https://t.co/e09pSTi2sa

[Tom Abbott @_tomabbott]

2/ We included 4793 patients aged over 50 years undergoing major open abdominal surgery from 70 hospitals across Italy, Spain, Norway, Sweden, South Africa & the UK between Feb 2016 & Nov 2019. @prismtrial @BruceBiccard @IbJammer @caldecoaal @CCPMG_TEAM https://t.co/e09pSTi2sa

[Tom Abbott @_tomabbott]

Published today in @LancetRespirMed is the final report of @prismtrial, an international multi-centre phase-3 randomised trial of routine postoperative CPAP to prevent pneumonia, re-intubation & death after major abdominal surgery https://t.co/e09pSTi2sa @rupert_pearse @QMULWHRI

[PRISM Trial @prismtrial]

The final report of PRISM trial has been published by @LancetRespirMed Here, @rupert_pearse gives a video summary https://t.co/g1P1ovrgkJ Thread below: @_tomabbott gives a summary of the key results.
Link to download paper: https://t.co/6ddka7hl20

[Tom Abbott @_tomabbott]

Published today in @LancetRespirMed is the final report of @prismtrial, an international multi-centre phase-3 randomised trial of routine postoperative CPAP to prevent pneumonia, re-intubation & death after major abdominal surgery https://t.co/e09pSTi2sa @rupert_pearse @QMULWHRI

[Dr Helgi @doctorhelgi]

Interesting trial of CPAP vs usual care post-op for major surgery by @rupert_pearse’s team. No difference between the groups though.

Important trial, especially as we might assume treatments like this work, they certainly make our numbers better. #Anaesthesia2021

[PRISM Trial @prismtrial]

For those that missed the talk at #Anaesthesia2021 you can see a pre-recorded video of @rupert_pearse presenting the results of @prismtrial here: https://t.co/g1P1ov9EW9
Or visit our website: https://t.co/VDmWMNjw7I https://t.co/KLgH1DQT2T

[PRISM Trial @prismtrial]

@prismtrial found no difference in the incidence of pneumonia, re-intubation or death within 30 days of surgery between patients randomised to CPAP or usual postoperative care. #Anaesthesia2021

[PRISM Trial @prismtrial]

@prismtrial recruited 4800 patients over 4 years from over 60 centres #Anaesthesia2021

[Royal College of Anaesthetists @RCoANews]

.@rupert_pearse explains in the prelude to @prismtrial - there *may* be a @CochraneUK signal towards the use of CPAP in abdominal surgery

#Anaesthesia2021

[PRISM Trial @prismtrial]

@rupert_pearse talking about the results of @prismtrial at #Anaesthesia2021 An international multi-centre randomised trial of routine postoperative CPAP after major abdominal surgery in 60 centres worldwide.

[PRISM Trial @prismtrial]

We are excited that @rupert_pearse will be presenting the results of @prismtrial at #Anaesthesia2021 at 12.10 today. Find out about routine postoperative CPAP here. @CCPMG_TEAM @RCoANews

[Tom Abbott @_tomabbott]

1/ Increasing numbers of patients aged 75 or older are undergoing surgery, but it is unclear whether these treatments are needed or whether they improve quality of life. https://t.co/WoZqlUrWQv @_alexfowler @rupert_pearse @BJSurgery

[Shaun May @DrShaunMay]

Patients with covid at ‘very high risk of death’ after surgery | Evening Standard Research from ⁦@_tomabbott⁩ ⁦@_alexfowler⁩ ⁦@rupert_pearse⁩ ⁦@CCPMG_TEAM⁩ ⁦@QMUL⁩ ⁦@standardnews⁩ https://t.co/aZcixy9JSR

[PRISM Trial @prismtrial]

@SorenPischke @rupert_pearse Thanks a lot for your help both! Not long left now! 😊

[Tom Abbott @_tomabbott]

We estimate that the financial cost of clearing the current backlog of postponed operations in @NHSEngland is ~£1.3bn. This could increase to over ~£5bn by March 2021 as the reintroduction of elective surgery will be gradual. https://t.co/YCfyF3psHK (Pre-print. Not peer-reviewed)