Finally out. A study on a library of heteroaromatic nitriles that enable a selection of appropriately reactive derivative for bioconjugation reactions. Great work by @projmatic@UL_FFA
https://t.co/eCSrkfftMB
When thiazole derivatives are identified as screening hits, their reactivity should be carefully addressed and correlated with specific on-target engagement. By @projmatic et al. from @UL_FFA.
Not all molecules that mislead are PAINS or aggregators:
An analysis of ways thiazoles can trick assays involving cysteine-bearing proteins @ACSMedChemLett
https://t.co/IHRSbhOcvS
@PracticalFrag@ACSMedChemLett Fragment-sized thiazole hits should indeed be carefully evaluated to confirm specific on-target engagement. Thanks for highlighting our research!
The First Paper published by DELopen users from University of Ljubljana, Slovenia #DELFinder
DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway https://t.co/OdsYb1WwJl #DELopen https://t.co/pk9EKfN6xg
Do you want to quickly check if your hit compound is a false positive hit due to redox activity? We present optimized and reliable assays that enable removing such nuisance compounds from hit-optimization campaigns. @projmatic@UL_FFA Drug Discovery Today https://t.co/soHoTcINnE
🏆 Winner announced! 🏆
The winner of the Advent Calendar contest is @projmatic, with his excellent 96-well Christmas tree.
Congratulation Matic, and a warm thanks to all our contestants.
#EFMCAdventCalendar#medchem#chembio
🎄Advent Calendar - Day 4 🎄
96-well Christmas tree from @projmatic 🎉
Do you have a festive pic for our advent calendar? Send it to us and get a chance to win a prize! 🎁
#EFMCAdventCalendar#medchem#chembio
The virtual poster hall at the #FiMC2021 conference is live! You can visit my poster: Discovery of selective fragment-sized immunoproteasome inhibitors. Many thanks to the authors from Budapest and Ljubljana for all their contributions #MedChem#FBDD