Devin Dersh

Senior Research Investigator @ Penn. Antigen processing & immune oncology

[Devin Dersh @proteinfolding]

Good chunk of my life right here! Glad to share with all. CRISPR screens uncover how MHC class I is globally regulated, with lots of lymphoma implications. We also ID drugs that may synergize with immunotherapies. Thanks to all collaborators!

[Immunity @ImmunityCP]

Online now: Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas https://t.co/PZLXD5lIbd

[Junwei Shi @junwei_s]

Excited to share our new work on direct protein-based genome editing in primary cells. We termed it Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas platform. This platform allows rapid and effective editing of primary cells with minimal toxicity. https://t.co/tRdFwotwcW

[poorly drawn lines @PDLComics]

a plant

[Ingo Hartung @HartungIngo]

A study by @genentech with huge implications for #TPD & #PROTAC space (efficacy & safety): Induced degradation of certain proteins generates peptides which bind to & induce cIAP1 autodegradation, leading to caspase activation & cell death. @biorxivpreprint https://t.co/zRJGObpEsW

[Addgene @Addgene]

As more and more people use long-read sequencing on their plasmids, we get more and more questions on plasmid multimers.

Well, have no fear, Plasmids 101 is here - with a post on Dimers and Multimers!

https://t.co/xP2y4nnODM

[Andy Minn @andyjminn]

A lot of perplexing data showing chronic interferon (IFN) promotes immunotherapy resistance. But why is chronic IFN different from acute, which clearly is important for response? New paper by @jingya & Bihui Xu shows one reason: inflammatory memory! (1/n) https://t.co/shlhQKr0Pf

[Devin Dersh @proteinfolding]

If you've ever wondered how MHC-I mutant tumors could be controlled... really neat work here

[Joris van de Haar @Joris_vd_Haar]

Impossible immunotherapy responses? It's the gamma delta's bro!

Thrilled to see our work on γδ T cells and "impossible" immunotherapy responses of B2M mutant cancers in @Nature.

🧵 below 👇👇👇

[Omer Dushek @Dushek]

The low antigen sensitivity of CAR-T cells is traced to their inefficient ability to exploit CD2 and LFA-1 compared to TCR-T cells. Our 'new' work now published in @PNASNews
https://t.co/TT92BZ999l

[Devin Dersh @proteinfolding]

@Jd_Kuldip_Singh @abhijit_MLab except the vast majority of audience will not remember 95% of content of an hour long seminar. getting major points across in a short talk can be a much better use of time for all involved - both presenter and audience

[Devin Dersh @proteinfolding]

me trying to avoid squeaking floors in the house every night https://t.co/q4UAaL2Z7x

[Simon Holland @simoncholland]

Call your dad now and ask him what the wifi password is so he has time to find the little paper it's written on before Thanksgiving.

[Andy Minn @andyjminn]

Lots of cool work recently on bad roles of IFNs in immunotherapy. Happy to share our collab study using JAK inhibitors plus anti-PD1 in NSCLC. Awesome team of @EJohnWherry, @divijmathew, @Jbauml, @MMarmarelis, others! Talking about it today @sitcancer. https://t.co/z8zpBDBPgz

[Devin Dersh @proteinfolding]

@WhySharksMatter why does shark blood have so much urea?

[Christopher Miller @chrizmillr]

20 years ago today our first show, CLONE HIGH, debuted.
Seems about time to unfreeze the clones.
They'll be fully thawed out in 2023 on HBOMax.

[Devin Dersh @proteinfolding]

@AdrianoAguzzi completely agree with you in general, but it is also a fair point that PhD programs prepare students to succeed in academic careers... which requires papers. going through the publication process is an important part of learning how the system works

[Devin Dersh @proteinfolding]

@PracheeAC I dunno, go to any journal club and it's people jumping over each other to point out flaws/holes in even top tier articles. I haven't met many people who completely trust papers outright. imo the most important thing that preprints did was to get information dispersed faster

[Devin Dersh @proteinfolding]

Love it https://t.co/haVk2wQnkN

[andrey a @aandr314]

I don't remember who posted it first

[John Connolly @John_E_Connolly]

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers | Nature Biomedical Engineering https://t.co/FUXwZ3Myub

[Devin Dersh @proteinfolding]

ok that's pretty wild...