PRIMED Consortium

The NIH-funded Polygenic Risk Methods Development (PRIMED) Consortium

[PRIMED Consortium @PRSmethods]

PRIMED Year in Review: Join us as we look back on some of what @PRSmethods consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/

[PRIMED Consortium @PRSmethods]

Congrats to @Yunfeng_Ruan and colleagues on this work which, incidentally, was part of why she won the @PRSmethods consortium award for "Most Creative Software Package Names" 🎉

[Pradeep Natarajan @pnatarajanmd]

Our study led by @Yunfeng_Ruan describes a method of interpolated polygenic risk scoring (DiscoDivas) for more accurate scoring across ancestries, particularly in settings of admixture https://t.co/oE6OwDp5Ey @AJHGNews
@AniruddhPatelMD @skoyamamd @buutrg @somijemmacho @HornsbyWhitney @AndrewHaoyu @nilanjan10c

[PRIMED Consortium @PRSmethods]

Join @PRSmethods investigators on May 13 to discuss integrating Social Determinants of Health (SDoH) and polygenic risk scores

🗓️Event information: https://t.co/bocgrt1HWY
🔖Publication: https://t.co/E3mq9ITdoE

[ASHG @GeneticsSociety]

The authors take the mic.
In this upcoming May 13 Journal Club Webinar,
@AJHGNews paper authors @sjcromermd, MD, MS, and David Conti, PhD, unpack what it takes to integrate PRS and SDoH across genetically and socially varied populations—LIVE: https://t.co/Qakzl5N83T
#ASHG

[Pradeep Natarajan @pnatarajanmd]

Very excited to share our study spearheaded by A. Misra & @AniruddhPatelMD describing the development & validation of our clinical multi-CVD polygenic risk score test, including how it might inform CVD prevention https://t.co/x6eXahw1Qp @JACCJournals

Any clinician can order this @MassGenBrigham @broadinstitute test today: https://t.co/pivEDisCZR

We used an integrated framework we previously developed and described to maximize performance and score stability, and allow for versioning as genomic interpretation continually improves.
https://t.co/YkPzcgSC8A
https://t.co/hezzuwNTvZ

The score was optimized in the nationwide @NIH @AllofUsResearch Program to enhance generalizability across communities, with validation in the @MassGenBrigham Biobank

@amandajowell @buutrg @aklfahed @shaan_khurshid @patrick_ellinor @nialljlennon @HornsbyWhitney @EWkarlson

[PRIMED Consortium @PRSmethods]

🔖 Also check out the @ourhealthstudy design recently published in @npjDigitalMed https://t.co/PdLk78qHzC

/end

[PRIMED Consortium @PRSmethods]

👀🧬🫀ICYMI - updated data release from the @ourhealthstudy of cardiovascular disease in South Asians now available on @useAnVIL!
https://t.co/JgzbjzBdkO

1/

[PRIMED Consortium @PRSmethods]

Funding for BGE sequencing and analyses are provided through the NIH-funded @PRSmethods consortium

For more information and how to apply for access, visit https://t.co/VxAMB8lHd3

3/

[OurHealth @ourhealthstudy]

📷📷 We’re excited to share that the OurHealth study is featured in @npjDigitalMed! Swipe to learn more about our study’s design and read the full article here: https://t.co/HwJWcMYibL . #OurHealth #hearthealth #research #southasian #cardiovascularhealth

[Iftikhar J. Kullo @iftikhar_kullo]

eMERGE returned PRS/Fam Hx/Mono results to n=23,840, 35% hi-risk for ≥1 of 11 diseases. Note: 1) high burden of genetic risk for common disease; 2) large-scale genomic risk assessment is feasible; 3) equity challenges must be addressed for implementation https://t.co/7S1HhVB5hM

[PRIMED Consortium @PRSmethods]

🎉🧬👀 New work out from Cromer et al. in the @PRSmethods consortium Social Determinants of Health Working Group, on how to model social and structural determinants of health jointly with genetic risk

[AJHG @AJHGNews]

🧬 New Review from Cromer et al!
📄 Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research
#PRS #SDoH
https://t.co/LmWqHWBAA8

[PRIMED Consortium @PRSmethods]

The @PRSmethods consortium - in 5 years, going from "Can we predict disease genetically" to "Can we predict disease in a way that's accurate, equitable, and clinically useful across diverse populations?"

Find out more at https://t.co/YRdua0JwZW

[PRIMED Consortium @PRSmethods]

The call for #DNADay26 essays is out! Open to students in grades 9-12 📝🧬

Pro tip for genetics professionals: the contest is also often looking for judges...

[ASHG @GeneticsSociety]

The #DNADay26 Essay Contest is HERE! 🧬This year’s challenge: Analyze a genetic treatment or therapy developed or widely used in recent years. Teachers—help your students share their ideas with the world! Submit by March 4 👉 https://t.co/2BjQ0ImSOd #ASHG

[PRIMED Consortium @PRSmethods]

Follow us for more highlights throughout the year and see our running lists of publications and research highlights
https://t.co/wmc7KTi5Gl
https://t.co/YRdua0JwZW
end/

[PRIMED Consortium @PRSmethods]

PRIMED Year in Review: Join us as we look back on some of what @PRSmethods consortium members accomplished in 2025 to help improve genetic risk prediction in global populations 1/

[PRIMED Consortium @PRSmethods]

November also saw the first data release of genetic and phenotypic data from the @ourhealthstudy , with blended genome-exome sequencing funded by PRIMED,
https://t.co/VxAMB8lHd3 6/

[PRIMED Consortium @PRSmethods]

Funding for BGE sequencing and analyses are provided through the NIH-funded PRIMED Consortium @PRSmethods

For more information and how to apply for access, visit https://t.co/VxAMB8lHd3
3/

[PRIMED Consortium @PRSmethods]

🧬🫀🌏 NEW data release from the @ourhealthstudy of Cardiovascular Disease in South Asians now available on @useAnVIL!
https://t.co/JgzbjzBdkO
1/

[PRIMED Consortium @PRSmethods]

The release includes self-reported basic demographics, anthropometric traits, cardiometabolic outcomes, and Blended Genome-Exome sequencing data on 621 study participants.
2/