Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826. New study from Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert Stewart, Patric Vaelli, and Bruce Bean @harvardbrainsci@harvardmed: https://t.co/xpbCqKwxdo
#MolecularPharmacology#IonChannels
@UTDPainLab It's very curious that the increasingly potent human Nav1.8 blockers share this voltage-dependent relief of inhibition. The VX compounds are comparatively weak on rodent Nav1.8, so it must be just the few AA (~25) replacements between the two that make all the difference
The world’s first paper using the QPatch Compact shows VX-150 and VX-548 target Nav1.8 ion channels for potential pain relief. Learn more and read the full paper here: https://t.co/IcCjaYw5bN
@MBTA@MBTA_CR Arrived Porter Sq red line 8:05 am, two trains "stopped". Waited until 8:24 for the 1st completely overcrowded train. Ppl couldn't get on and now I'm late for work 👍