Peter Markov

Epidemiology, viruses, emergence, evolution
Joint Research Centre
London School of Hygiene & Tropical Medicine
Formerly: ECDC, Uni of Oxford
Opinions are my own

[Peter Markov @pvmarkov]

Our review paper on the evolution of SARS-CoV-2 with @ArisKatzourakis, @Mahan_Ghafari, @Simmonds_Lab, @katrina_lythgoe just out in @NatureRevMicro https://t.co/kgtAQ2mhIJ

[Peter Markov @pvmarkov]

📌Our latest work is out!
Effectiveness of remdesivir treatment and early hospitalisation against COVID-19.
Modelling driven by fearsomely skilled and effective @SchuhLea. Check out her🧵and read the paper🎯

[lea.schuh @SchuhLea]

How effective are treatments against COVID-19? 🦠💉😷

Check out our newest publication in #JRSocInterface and take a 👀
https://t.co/uDqHysr5jq 🎉

A short 🧵

[Peter Markov @pvmarkov]

"We embedded the overall effectiveness of the activity of the immune capacity against SARS-CoV-2 within the quantity, representing the combined effects of innate immunity, adaptive immunity, and immune memory on the ability to control the virus."

[Emmanuel @ejustin46]

5) Fig. Model fits and simulation of reinfection with virus variants with two different changes in properties: increased infectivity and immune escape

[Peter Markov @pvmarkov]

📢Two exciting positions to work on #AI, #MachineLearning & #LLMs
🚀 with some very smart, nice and productive people
🎯 at the @EU_ScienceHub in Ispra, Northern Italy.

🔎Details below.

[Victoria Ruiz @victoriaISruiz]

🚨Job alert
We have 𝟮 𝗼𝗽𝗲𝗻 𝗽𝗼𝘀𝗶𝘁𝗶𝗼𝗻𝘀 in our Unit at JRC (F7 Digital Health), one as 𝗖𝗮𝘂𝘀𝗮𝗹 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁 (Geel) and the other as 𝗥𝗲𝗶𝗻𝗳𝗼𝗿𝗰𝗲𝗺𝗲𝗻𝘁 𝗟𝗲𝗮𝗿𝗻𝗶𝗻𝗴 𝗦𝗰𝗶𝗲𝗻𝘁𝗶𝘀𝘁 (Ispra)
👉Deadline: 10/04/2024

[Emmanuel @ejustin46]

WITHIN-HOST (re)INFECTION DYNAMICS of SARS-CoV-2
(very interesting study from @pvmarkov and colleagues)
https://t.co/O1LpdgXH4N

[Peter Markov @pvmarkov]

Our work on withinhost reinfection dynamics of SARS-CoV-2 w/ @SchuhLea et al. at @EU_ScienceHub now published in #MathematicalBiosciences
We model reinfections with higher infectivity & immune escape
- Find🧵with the key points below
- The paper is here: https://t.co/hz7b40dnUi

[lea.schuh @SchuhLea]

Our new #preprint on “A mathematical model for the within-host (re)infection dynamics of SARS-CoV-2” is out on @arxiv! 📄🦠💻😷
Thanks to @pvmarkov, Vladimir Veliov and Nikolaos Stilianakis for this collab! 🙏
https://t.co/Y4veVI8EU4
A quick 🧵.

[Peter Markov @pvmarkov]

👉5 more days to apply!
A postdoc with us (near Milano, Italy) to riskmap local transmission of tropical fevers in EU
📣Exciting research
📣Productive team
📣Freedom to formulate questions
📣Excellent pay & work conditions
with @pvmarkov
at @EU_ScienceHub
https://t.co/lR79udT4X4

[Peter Markov @pvmarkov]

📢Our work on SARS-CoV-2 within-host dynamics led by @SchuhLea in collaboration with Prof Vladimir Veliov from @tu_wien now out in preprint
Of note, we investigate properties of viral & immune dynamics upon reinfection with variants featuring:
👉Higher infectivity
👉Immune escape

[lea.schuh @SchuhLea]

Our new #preprint on “A mathematical model for the within-host (re)infection dynamics of SARS-CoV-2” is out on @arxiv! 📄🦠💻😷
Thanks to @pvmarkov, Vladimir Veliov and Nikolaos Stilianakis for this collab! 🙏
https://t.co/Y4veVI8EU4
A quick 🧵.

[Emmanuel @ejustin46]

👍CHART to understand the difference between INTRINSIC and DISEASE SEVERITY

and that "the notion that viruses will evolve to be less virulent to spare their hosts is one of the most persistent myths surrounding pathogen evolution."
Thx to @yaneerbaryam
https://t.co/K55cMR42RM

[Peter Markov @pvmarkov]

@kallmemeg This reminds me a bit of a line from Milosh Formann's 'Hair', where one of the characters asked by a prison committee (I think, quoting from memory) if he was gay responded by saying no, but I wouldn't kick Mick Jagger out of my bed =))
Happy Lesbians Day!

[Peter Markov @pvmarkov]

@BillHanage @kallmemeg =))

[Peter Markov @pvmarkov]

Great 🧵by @LongDesertTrain on historical & political constraints on acceptance of airborne spread for SARS-CoV-2 and other major pathogens. 🎯

[Ryan Hisner @LongDesertTrain]

Chaplin's view was influential—not because the evidence favored droplet transmission but because his views led to politically acceptable conclusions. With droplet transmission no public action or business regulation was required. @BenEhrenreich: 2/3 https://t.co/8MKZzDRlGN

[Peter Markov @pvmarkov]

We say: "A key determinant of the rate at which a virus evolves is its mutation rate" which means a different thing. "The rate at which a virus evolves" is a definition of the substitution rate, rather than the mutation rate.
@Mahan_Ghafari
@ArisKatzourakis
@NatureRevMicro

[Peter Markov @pvmarkov]

@ejustin46, thanks for using our work to illustrate your nice post! Just a minor correction:
The statement "MUTATION rate is 'the rate at which a virus evolves'" in your post is incorrect. We don't say this in our paper, but the use of quotation marks seems to imply so.

[Emmanuel @ejustin46]

2) The excellent study “The evolution of SARS-CoV-2” clarifies the difference between the 2 rates :
The MUTATION rate is "the rate at which a virus evolves. This is the intrinsic rate at which genetic changes emerge per replication cycle"
https://t.co/DPLQJ6lPGJ

[Peter Markov @pvmarkov]

Thanks @MarionKoopmans! No better credit than seeing my figure in the lecture theatre! @NatureRevMicro

[Marion Koopmans, publications: https://pure.eur.nl @MarionKoopmans]

Preparing for teaching, master students update on key outstanding questions after they did their own SARS COV 2 case studies. Really like this figure in nat mic review published earlier this year, that is an excellent description of viral diversity https://t.co/sc8ZLmKEVi

[Peter Markov @pvmarkov]

@SGriffin_Lab @MarionKoopmans Thanks Stephen - good point, especially given we did discuss viral evolution in response to APOBEC and other components of the innate response in the text.

[Ashley York 💙 @ashleyyork_]

Celebrating 20 years of Nature Reviews Microbiology and progress in the field! 🥳🎉

We're immensely grateful for the extraordinary support from our dedicated community of readers, authors and peer-reviewers over two decades 🙌📚✍️💖

Here's to the next 20 years of progress!

[Peter Markov @pvmarkov]

🚀Two final days still left to submit applications for this post, combining interesting epidemiological science 🔭, great geographical location🎯, outstanding remuneration💶& conditions of work👩‍🎓

[Peter Markov @pvmarkov]

👉We are hiring. Again!
A new post to work on combining indicator & event based infection surveillance + map risk of emergence
📣Exciting research
📣Freedom to choose your questions within the topic 📣Attractive pay
📣In our Belgian campus not far from Brussels
@EU_ScienceHub

[Peter Markov @pvmarkov]

📢These two Postdoc positions are closing tonight. You still have time to file in your application and carry out some cool research🔬with us at the JRC in the next 3 years! 🚀

[Peter Markov @pvmarkov]

👉We are hiring! Two posts to study & risk map infection emergence in EU
📣Exciting research
📣Productive team
📣Freedom to formulate questions
📣North Italy: wealth of culture, history, outdoors, good food & stunning nature
📣Excellent pay & work conditions
@EU_ScienceHub

[Salla Saastamoinen @SallaLoi]

@EU_ScienceHub is great place to work 👍

[Peter Markov @pvmarkov]

👉We are hiring! Two posts to study & risk map infection emergence in EU
📣Exciting research
📣Productive team
📣Freedom to formulate questions
📣North Italy: wealth of culture, history, outdoors, good food & stunning nature
📣Excellent pay & work conditions
@EU_ScienceHub

[IDDjobs: infectious disease dynamics jobs @IDDjobs]

2 Postdocs (Ispra (near Milano), Italy) Investigate environmental and non-environmental factors for emergence of infections and develop risk maps of emergence in Europe
with
@pvmarkov, Nikolaos Stilianakis
at @EU_ScienceHub
More details: https://t.co/FhlxFn0wwF