Catching up with Pumpkinseed Bio today 🐠
The colorful wafer contains billions of optical nanosensors for sequencing peptides and proteins. Each amino acid in the protein chain is read sequentially from its unique vibrational signature. Protein sequencing has proven to be a more difficult challenge than DNA sequencing, but Pumpkinseed made it accurate and fast with a huge silicon photonics array performing Raman spectroscopy in parallel. This allows analysis of the proteome with all of its post-translational complexity, a new lens into the inner workings of our biology.
The company is named Pumpkinseed after the most colorful freshwater fish in North America, bearing a likeness to their chips, from the diffraction grating effect of their sensor arrays.
I put my 8” wafer of 100 MHz Intel Pentiums next to it for comparison. Gordon Moore gave that to me in 1994, and when I was a student of Andy Grove, he was kind enough to sign it.
• Some more background: https://t.co/Xd9o8LRN7W
• Inquiries: https://t.co/41OCJ0A24v
A team of German scientists have developed tattoos that change color according to the body's levels of glucose, albumin an pH levels.
This would allow patients with chronic diseases keep track of their health without having to take constant blood samples.
SOUND ON. You’re hearing the first howl of a dire wolf in over 10,000 years. Meet Romulus and Remus—the world’s first de-extinct animals, born on October 1, 2024.
The dire wolf has been extinct for over 10,000 years. These two wolves were brought back from extinction using genetic edits derived from a complete dire wolf genome, meticulously reconstructed by Colossal from ancient DNA found in fossils dating back 11,500 and 72,000 years. This moment marks not only a milestone for us as a company but also a leap forward for science, conservation, and humanity. From the beginning, our goal has been clear: “To revolutionize history and be the first company to use CRISPR technology successfully in the de-extinction of previously lost species.” By achieving this, we continue to push forward our broader mission on—accepting humanity’s duty to restore Earth to a healthier state.
But this isn’t just our moment—it’s one for science, our planet, and humankind. All of which we love and are passionate about. Now, close your eyes and listen to that howl once more. Think about what this means for all of us.
Sometimes your journey is going to be lonely. When you’re growing and changing, you’ll stop fitting into the old but you’ve yet to attract the new. That’s ok. Those periods of loneliness are the cost of entry. They’re a sign you’re on the right path.
Top 10 Manu Prakash teachings from his amazing episode of the Night Science Podcast.
1. Science is a sense of wonder; a personal sense of experience.
2. Science gives us increasing agency; you realize it’s like a car you drive with no roads.
🧵⬇️
@ManuPra18599785@MartinJLercher
This is a beautiful passage from Rumi:
The wound is the place where the Light enters you.
In Ancient Indian traditions, there is a belief in a concept called the Wheel of Time (or "kalachakra").
The idea is that time goes through a natural three-part cycle:
• Creation
• Destruction
• Rebirth
Every period of creation is followed by a period of destruction. Every period of destruction is followed by a rebirth and period of creation.
This has always resonated with me.
I believe our lives follow a similar natural cycle from creation (growth) to destruction (struggle) to rebirth (new beginnings).
The true wisdom is found in outlasting the darkness of the periods of destruction—knowing that the darkness is a necessary precursor to your rebirth.
As Rumi wrote, the wound (darkness) is the place where the Light (rebirth) enters you.
Lesson: View each period of pain, sorrow, and struggle as a natural precursor to your inevitable growth. Have faith. Sit with it. Allow that light to enter and grow within you before it shines for everyone to see.
After a long vacay and then getting sick, it’s finally been a week full of work satisfaction, feminine energy, friendships, laughter and healing! Sending out much love and positivity to the world tonight 💕
"Science is fun and being a scientist is a fun job!"
On this year's International Day for Women and Girls in Science, listen to 2023 medicine laureate Katalin Karikó speak about being a scientist.
What is your favourite thing about being a scientist?
#womeninscience
My interview w/ Manu Prakash @PrakashLab, a hero of mine, who I think is one the great innovators of our era. With global impact for frugal, ingenious inventions as you'll see in this thread https://t.co/iVcjBc0Lf6 @Medscape w/ transcript @TeamFoldscope@StanfordEng@Stanford
@dr_alphalyrae All are great topics so maybe a whole series if you have the bandwidth? I’d say networking for PhDs as well- I think it’s so underrated but extremely useful! Happy to bounce off ideas/help too.
On a side note, I’ve related to a lot of your content!:)