This has quietly been a miracle month in medicine.
In the last 5 weeks we’ve got news on:
- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors
This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.
Our first reasoning model, trained from scratch is finally out. Been an incredibly fun and rewarding experience building a clean model from scratch with focus on simplicity, scalability, and careful attention to detail.
Tech report with lots of training details: https://t.co/w1Y5ecscTL
microsoft MAI tech report is a gold mine, one of the most transparent for a model at this scale.
this model uses zero synthetic data or distillation from previous models. this means reasoning, agentic behavior, tool use are all learned fully during post-training with no cold start. bold choice that makes it harder and requires more iterations to reach sota, but you get FULL control over your model series and it proves they are serious about being a frontier lab.
the tech report is insanely detailed and precise about numbers. to give an example, they give the exact MFU across all the iterations of the model, with the exact changes etc. they also share the full scaling ladder recipe, to my knowledge this is the first time i've seen this in a tech report at this scale
let's look at all of this in this likely very long thread 🧵
Google’s Gemma 4 E2B running on-device on iPhone 17 Pro
Gemma 4 is built from the same research as Gemini 3, has image understanding capabilities and can reason if needed
Running at ~40tk/s with MLX optimized for Apple Silicon
Conversations tend to go better with a face and a voice. That’s why we’re thrilled to release the beta version of the first video chat skill for ANY agent, powered by our new real-time model, PikaStream1.0.
The skill preserves memory and personality, and enables real-time adaptability. And if you use it with your Pika AI Self, they’ll be able to execute agentic tasks during the call 💅
This is kind of awesome!
You can send a Google Meet invite to your agent (OpenClaw, Claude, whatever) and have them join you on a real-time video call.
Just think about that for a second:
You're talking "face to face" to your agent.
I think Pika found gold here.
Thank you to everyone who spent time sending us feedback and reports. We've investigated and we're sorry this has been a bad experience.
Here's what we found:
not an April Fools joke, we rewrote the Claude Code renderer to use a virtual viewport
you can use your mouse, the prompt input stays at the bottom, and a lot more small UX wins people have been asking for
it's experimental so give us your feedback
We're going around the Moon. Come watch with us. Artemis II's four-astronaut crew is lifting off from @NASAKennedy on an approximately 10-day mission that will bring us closer to living on the Moon and Mars. The launch window opens at 6:24pm ET (2224 UTC). https://t.co/X27QJejNDt
I was fired from Anthropic today.
I was the engineer responsible for shipping the latest dev/claude-code npm package. Wanting to improve the debugging experience for the team, I decided to include source maps in the release. This resulted in our entire internal codebase being publicly exposed including thousands of files with every agent command, all system prompts, the complete query engine, Undercover Mode, Bypass Permissions Mode, and our internal telemetry configuration.
I take full responsibility. I genuinely believed the safeguards Claude Code had built for me would be adequate and it was a serious miscalculation on my part.
My actions have unintentionally open-sourced major parts of Claude’s architecture well ahead of schedule. I apologize to the team and to Claude.
We’ve seen Claude Code users bring in Codex for code review and use GPT-5.4 for more complex tasks, so we thought: why not make that easier?
Today we’re open sourcing a plugin for it! You can call Codex from Claude Code with your ChatGPT subscription.
We love an open ecosystem!
The new Qwen 3.5 by @Alibaba_Qwen running on-device on iPhone 17 Pro.
Qwen 3.5 beats models 4 times its size, has strong visual understanding, and can toggle reasoning on or off.
The 2B 6-bit model here is running with MLX optimized for Apple Silicon.